Orthopaedic Trauma Association

Research Grant History

Grant History: 1990 - 2010
Funded proposals - 176
Presentations resulting from OTA funded studies 304
Publications resulting from OTA funded studies:125
Additional Grants and Awards: $16,968,870.00

2010 Awarded Grants

> Clinical and Basic Research Grant Awards

> Resident Grant Awards (grant cycle: January 1, 2010 - December. 31, 2010)

Orthopaedic Trauma Association History of Grants
(please click on the year you are interested in researching, or scroll to view the entire grant history list).

2010	2009	2008
2007	2006	2005
2004	2003	2002
2001	2000	1999
1998	1997	1996
1995	1994	1993
1992	1991	1990

2010

OTA 2010 GRANT AWARDS (grant cycle: 1/1/2010 – 12/31/2010)

Directed Topic Clinical Study (up to $50,000/year, 3-year funding cycle)
(Proximal Humerus Fractures, Economic Outcomes in Trauma Care, Clinical Trial Re-evaluation of non-operative problems, Effect of non-operative post surgical therapy in trauma)

Title: Decreasing Long Term Complications and Cost Following Hip Fracture using a Medical Home Concept (MHC)
PI: Wade Smith
Co-PI: Jove Graham
Requested Funds: $97,785

Clinical Grant Applications (up to $40,000/year, 2 year grant cycle)

Title: Multidisciplinary care of the geriatric patient with fractures below the hip
PI: Gregory Della Rocca
Co-PI: Yvonne Murtha
Requested Funds: $61,038

Title: Prevalence of Abuse With An Intimate Partner Violence Surgical Evaluation (P.R.A.I.S.E.)
PI: Brad Petrisor
Co-PI: Mohit Bhandari
Requested Funds: $30,000

Title: Effects of the Presence of Microbial Biofilms on the Healing of Osseous Fractures Treated With Internal Fixation
PI: Daniel Altman
Co-PI: Greg Altman
Requested Funds: $75,000 (note: requested $80,000)

Basic Research Grants (up to $25,000, 1 year grant cycle)

Title: Heterotopic Ossification in an Animal Extremity Blast Model
PI: Robert O'Toole
Co-PI: Vincent Pellegrini
Requested Funds: $25,000

Title: The Synergistic Effects of VEGF on BMP-induced Osteogenic Differentiation of Bone Marrow Stem Cells
PI: Quanjun Cui
Co-PI: Gary Balian
Requested Funds: $25,000

Title: Engineering the Bioactivity of Absorbable Magnesium Implants for Fracture Fixation and Bone Defect Scaffolds: The Effect of Calcium Phosphate Coatings on In-Vitro Biocorrosion and Osteogenic Differentiation of Mesenchymal Stem Cells.
PI: Lawrence Bone
Co-PI: Shuying Yang
Requested Funds: $25,000

Title: Endothelial Progenitor Cells for Healing and Angiogenesis in a Segmental Bone Defect Model: A Comparison With Mesenchymal Stem Cells
PI: Aaron Nauth
Co-PI: Emil Schemitsch
Requested Funds: $25,000

Title: Preferential Peroneal Nerve Palsy after Posterior Hip Dislocation and Acetabular Surgery: A Cadaveric Study
PI: Ivan Tarkin
Co-PI: Hans-Christoph Pape
Requested Funds: $25,000

OTA 2010 RESIDENT $10,000 GRANT AWARDS

January 1, 2010– December 31, 2010 Grant Cycl

Principal Investigator: Alberto Carli, MD, C.M.
Co-Investigator: Edward J. Harvey, MD, CM
Grant Title: Chitosan-Mediated FGF18 Delivery for Assisted Bone Repair

P rincipal Investigator: Jesse Alan Shantz, MD MBA
Co-Investigator: David Sanders, MD
Grant Title: The Efficacy and Cost Effectiveness of Preoperative and Postoperative Cryotherapy in Proximal Tibia Fractures

Principal Investigator: Eric R Henderson, MD
Co-Investigator: Henry Claude Sagi, M
Grant Title: Tension Tension Band Wiring of Patella Fractures Separating Fact from Fiction- A Biomechanical Study

Principal Investigator: Vikram M Sathyendra, MD
Co-Investigator: John S. Reid, MD
Grant Title: Expression of single nucleotide polymorphisms in delayed fracture healing

Principal Investigator: Roshan P Shah, MD, JD
Co-Investigator: Samir Mehta, MD
Grant Title: The Effect of Low Magnitude Mechanical Signals on Tibial Shaft Fracture Healing

Principal Investigator: Brandon M. Steen, MD
Co-Investigator: Thomas A. Einhorn, MD
Grant Title: The Comparison of the Therapeutic Potential of Isolated BMP-2 Producing Progenitor Cells, Bone Marrow Aspirates and Recombinant BMP-2 in Rodent Models of Bone Formation

Principal Investigator: Ty Fowler, MD
Co-Investigator: Kevin J. Pugh, MD
Grant Title: Tension Band Fixation of the Medial Malleous using Fiberwire. Suture: A Biomechanical Study

Principal Investigator: Kristine E Banks, MD
Co-Investigator: Milan Sen, MD
Grant Title: Locking Plate Fixation of Patella Fractures: A Biomechanical Study

2009

Title: Psychological Factors Predict Disability After Awarded Grant: $80,000 (2-year)
Musculoskeletal Trauma
Principal Investigator: Ana-Maria Vranceanu, PhD
Co-Principal Investigator: David Ring, MD, PhD

Title: Early Psychiatric Intervention after Orthopaedic Awarded Grant: $148,806 (3-year)
Trauma: A Prospective, Randomized Double-Blinded Placebo Controlled Trial
Principal Investigator: Adam Starr, MD
Co-Principal Investigator: Joseph Borrelli, MD

Title of Grant: “Development and testing of a postoperative pain outcome tool for orthopaedic trauma surgery"
Principal Investigator: Kristin Archer, PhD
Co-Investigator: William Obremskey, MD, MPH
Amount and Date Funded:
          $131,100 (3-year)
Presentations: No
Publications:   No
Additional Grants and Awards: None
Status: Ongoing. Financial report and grant history submitted 01/15/10.

Title: The role of Antibiotics in Open Fractures Revisited: Awarded Grant: $80,000 (2-year)
Characteristics of Staphylococcus Aureus and Susceptibility Profile
Principal Investigator: Carla Saveli, MD
Co-Principal Investigator: Steven Morgan, MD

Clinical Grant Applications (up to $40,000/year, 2 year grant cycle)

Title: Operative and Non-Operative Scapular Body and Awarded Grant: $80,000 (5-year)
Glenoid Neck Fracture Treatment Indications
Principal Investigator: Clifford Jones, MD
Co-Principal Investigator: Debra Sietsema, PhD

Basic Research Grants (up to $25,000, 1 year grant cycle)

Title: Local Drug Delivery Systems for the Treatment of Infections
Principal Investigator: Michael Bosse, MD
Co-Principal Investigator: John Ellington, MD
Awarded Grant: $24,200

Title of Grant: Acute Cartilage Damage Associated with Intraarticular Fractures
Principal Investigator: Yuki Tochigi, MD, PhD
Co-Investigator: Todd McKinley, MD
Amount and Date Funded: $25,000 - January 1, 2009 - December 31, 2009
Presentations:Meeting

Tochigi Y, Martin JA, Rudert MJ, McCabe D, Goreham-Voss CM, Buckwalter JA, Brown TD. Acute phase pathology of cartilage injury in human ankle intraarticular fractures. 55th Annual Meeting of the Orthopaedic Research Society, February 22–25, 2009, Las Vegas, Nevada. Abstract ID: ORS2009-2661, Poster Presentation #1078, Poster Session 25: Cartilage Impact Models.
Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. A new insult technique for a large animal survival model of human intra-articular fracture. OARSI World Congress on Osteoarthritis 2009, September 10–13, 2009, Montreal, Quebec, Canada. Abstract Control #589, Poster Presentation.
Tochigi Y, Martin JA, Lehman A, Vaseenon T, Zhang P, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in human ankle intraarticular fractures. OARSI World Congress on Osteoarthritis 2009, September 10–13, 2009, Montreal, Quebec, Canada. Abstract Control #183, Poster Presentation.
Tochigi Y, Martin JA, Lehman A, McKinley TO, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in ankle intra-articular fractures. 2009 Orthopaedic Trauma Association Pre-Meeting Courses: Basic Science Focus Form, October 7–8, 2009, San Diego, California. Abstract #: 435, Final Program Paper #: BSFF 11, Podium Presentation.
Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. Development of a large survival animal model of human intraarticular fracture: A new technique to replicate cell-level cartilage pathology in the porcine hock in vivo. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010, New Orleans, Louisiana. Abstract ID: ORS2010-2172. Paper #:355: Short Talk Session 12 Biology of Fracture Repair.
Tochigi Y, Buckwalter JA, Zhang P, Vaseenon T, Lehman AD, Martin JA, Brown TD. Distribution and progression of chondrocyte damage in human ankle intraarticular fractures. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010, New Orleans, Louisiana. Abstract ID: ORS2010–2200. Poster #943: Session 25 Cartilage Matrix Degradation.
Zhang P, Tochigi Y, Sauter EE, Martin JA, Brown TD. Chondrocyte death cascade in fracture-damaged cartilage in a porcine whole-organ model. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010, New Orleans, Louisiana. Abstract ID: ORS2010-2149. Poster #952 : Session 25 Cartilage Matrix Degradation.

Publications: Yes
Name of Publication Month/Year Volume #

Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. A new insult technique for a large animal survival model of human intra-articular fracture. Osteoarthritis Cartilage 2009;17(Supp 1):S51–52.
Tochigi Y, Martin JA, Lehman A, Vaseenon T, Zhang P, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in human ankle intraarticular fractures. Osteoarthritis Cartilage 2009;17(Supp 1):S112–113.

Did this research grant lead to the development of a larger grant and additional awards from other sources?              No

Did this research grant lead to the development of a patent?   No

Is this project concluded No

If the project is not concluded, are additional publications and related grants expected? Yes
Pending Publications

Tochigi Y, Buckwalter JA, Martin JA, Hillis SL, Zhang P, Vaseenon T, Lehman AD, Brown TD. Distribution and progression of chondrocyte damage in a quasi-in-vivo model of human intra-articular fracture. J. Bone Joint Surg. (Submitted December 2009)

Pending Grants
Title: Prompting Cartilage Stem Cell Activity to Improve Recovery From Joint Fracture
Funding Source: Department of the Army — USAMRAA
Project Dates: 07/01/10–12/31/11
Total Project Costs: $143,756
Submitted: September 2009

Title: A Clinically Realistic Large Animal Model of Intra-Articular Fracture
Funding Source: Department of the Army — USAMRAA
Project Dates: 09/01/10–08/31/13
Total Project Costs: $1,348,328
Submitted: November 2009

Project Status: Ongoing.

Classification Database and Outcomes Committee Pilot Project

Title: Development of Fracture Specific MFA Outcomes Scores - Pilot Project for Planning the
Major Investigation
Principal Investigator: Douglas W. Lundy, MD
Co-Principal Investigator: Julie Agel, MA
Awarded Grant: $6,003

rhBMP-2 (up to $65,000/year, 2 - 3 year funding cycle)

**Basic**

Title: Combined Use of Recombinant Human Bone Morphogenetic Protein-2 and Low Intensity Pulsed
Ultrasound in Orthopedic Traumatology
Principal Investigator: Amarjit Virdi, PhD
Co-Principal Investigator: Walter Virkus, MD
Awarded Grant: $129,709 (2-year)

OTA 2009 RESIDENT $10,000 GRANT AWARDS

June 1, 2009– May 31, 2010 Grant Cycle

Principal Investigator: Jonathon G. Eastman, MD

Co-Investigator: Brad J. Yoo, MD

Grant Title: Retropatellar Technique for Intramedullary Nailing of Tibia Fractures: A Prospective Evaluation

Grant Funded by: AO North America/OTA

Principal Investigator: Reza Firoozabadi, MD

Co-Investigator: Utku Kandemir, MD

Grant Title: Does Plugging unused screw holes increase the strength of locked compression plates in comminuted supracondylar femur fractures?

Grant Funded by: AO North America/OTA

Principal Investigator: Jaymes Granata, MD

Co-Investigator: Thomas J.Ellis, MD

Grant Title: Immediate Weight Bearing of Comminuted Distal Femur Fractures Using Locked Plate Fixation: A Biomechanical Analysis

Grant Funded by: Foundation for Orthopaedic Trauma /OTA

Principal Investigator: Igor Immerman, MD

Co-Investigator: Kenneth A. Egol, MD

Grant Title: The Stability of the Postero-Medial Tibial Plateau Fracture Fragment Depends on Fragment Size, Knee Flexion Angle, and Applied Load

Grant Funded by: Foundation for Orthopaedic Trauma /OTA

Principal Investigator: Michael P. Kelly, MD

Co-Investigator: Utku Kandemir, MD

Grant Title: The effect of screw size on fatigue strength of fixation with statically locked Intramedullary Nails in Comminuted Femoral Shaft Fractures

Grant Funded by: Foundation for Orthopaedic Trauma /OTA

Principal Investigator: Jeremiah Jonathan Maddox, MD

Co-Investigator: James P. Stannard, MD

Grant Title: The Effect of Repetitive Insertion On The Pullout Strength of Screws

Grant Funded by: OTA

Principal Investigator: Jason C. Phillips, MD

Co-Investigator: James S. Raphael, MD

Grant Title: The effect of statin lipophilicity on bone fracture healing

Grant Funded by:

Principal Investigator: Brian A. Silvia, MD,PhD

Co-Investigator: Thomas Goss, MD

Grant Title: Preliminary study to identify osteoblastic cells in the peripheral circulation in mice.

Grant Funded by: OTA

Principal Investigator: Richelle Carrie Takemoto, MD

Co-Investigator: Kenneth A. Egol, MD

Grant Title: Quantitative Assessment of Osteogenic Genes and Proteins from Alternate Bone-
Graft Harvesting Sites.

Grant Funded by: OTA

Principal Investigator: Sarah R. Zawodny, MD

Co-Investigator: Quanjun Cui, MD

Grant Title: Osteotropic Peptides: Therapy for Post-traumatic Osteonecrosis of the Femoral Head
Grant Funded by: OTA

2009

January 1, 2009 – December 31, 2009 Grant Cycle

$10,000 Resident Grant Recipients

Title of Grant
Harnessing Collective Intelligence for the Management of Subcapital Hip Fractures
Principal Investigator: Jaimo Ahn, MD, PhD
Co-Investigator: Joseph Bernstein, MD, MS
Amount Funded: $10,000
Presentations:
Publications:
Additional Grants and Awards:
Project Status

Title of Grant
   Inflammatory Response to Trauma in the Obese
Principal Investigator:  Arun Aneja, MD
Co-Investigator: George Russell, MD
Amount and Date Funded:
             $10,000
Presentations:
Missipppi Orthopaedic Society 5/10
Will submit to ORS 2011
Publications: No
Additional Grants and Awards: Yes
   Mississippi Institute of Minority Health - $5,000 Funding Cycle 5/09-5/10
Project Status - Ongoing - Pending Publications: Microcirculation Journal - awaiting results/date submitted 03/10

Principal Investigator: Erik Hansen, MD Amount Funded: $10,000
Co-Investigator: Utku Kandemir, MD
Grant Title: Measurement of Tissue Oxygenation for Diagnosis of Acute Compartment Syndrome following Tibia Fracture: A Pilot Study

Principal Investigator: Raj Kakarlapudi, MD Amount Funded: $10,000
Co-Investigator: Brett Crist, MD
Grant Title: Osteogenic Cell Viability in Bone Graft Obtained in Reamer Irrigator and Aspirator (RIA) System Versus Iliac Crest Bone Graft

Principal Investigator: Ethan Kellum, MD, MS Amount Funded: $10,000
Co-Investigator: Michael Tucker, MD/
Grant Title: The effects of suramin treatment on fracture healing and muscle regeneration in a rodent model

Principal Investigator: James Starman, MD Amount Funded: $10,000
Co-Investigator: Michael Bosse, MD
Grant Title: Foreign-body Induced Biomembranes in Segmental Bone Defects: Histologic, Immunohistochemical, and Gene Expression Properties in a Rat Model

Principal Investigator: Aaron Nauth, MD Amount Funded: $10,000
Co-Investigator: Emil Schemitsch, MD FRCSC
Grant Title: Effect of Mesenchymal Stem Cell-Based Gene Transfer of VEGF and eNOS on Healing of a Segmental Bone Defect

Principal Investigator: Matthew Futvoye, MD Amount Funded: $10,000
Co-Investigator: George Russell, MD
Grant Title: Vacuum assisted closure of acetabular fracture incisional wounds in the obese.

Principal Investigator: Thomas Jones, MD Amount Funded: $10,000
Co-Investigator: Laura Prokuski, MD
Grant Title: Sterility of Intraoperative Irrigation

Principal Investigator: Tamara Pylawka, MD Amount Funded: $10,000
Co-Investigator: Spence Reid, MD
Grant Title: Characterization of the Interface between Neocartilage Produced by Nonarticular Chondrocytes and the Subchondral Bone

2008

Principal Investigator: Jonathon G. Eastman, MD

Co-Investigator: Brad J. Yoo, MD

Grant Title: Retropatellar Technique for Intramedullary Nailing of Tibia Fractures: A Prospective Evaluation

Grant Funded by: AO North America/OTA

Principal Investigator: Reza Firoozabadi, MD

Co-Investigator: Utku Kandemir, MD

Grant Title: Does Plugging unused screw holes increase the strength of locked compression plates in comminuted supracondylar femur fractures?

Grant Funded by: AO North America/OTA

Principal Investigator: Jaymes Granata, MD

Co-Investigator: Thomas J.Ellis, MD

Grant Title: Immediate Weight Bearing of Comminuted Distal Femur Fractures Using Locked Plate Fixation: A Biomechanical Analysis

Grant Funded by: Foundation for Orthopaedic Trauma /OTA

Principal Investigator: Igor Immerman, MD

Co-Investigator: Kenneth A. Egol, MD

Grant Title: The Stability of the Postero-Medial Tibial Plateau Fracture Fragment Depends on Fragment Size, Knee Flexion Angle, and Applied Load

Grant Funded by: Foundation for Orthopaedic Trauma /OTA

Principal Investigator: Michael P. Kelly, MD

Co-Investigator: Utku Kandemir, MD

Grant Title: The effect of screw size on fatigue strength of fixation with statically locked Intramedullary Nails in Comminuted Femoral Shaft Fractures

Grant Funded by: Foundation for Orthopaedic Trauma /OTA

Principal Investigator: Jeremiah Jonathan Maddox, MD

Co-Investigator: James P. Stannard, MD

Grant Title: The Effect of Repetitive Insertion On The Pullout Strength of Screws

Grant Funded by: OTA

Principal Investigator: Jason C. Phillips, MD

Co-Investigator: James S. Raphael, MD

Grant Title: The effect of statin lipophilicity on bone fracture healing

Grant Funded by:

Principal Investigator: Brian A. Silvia, MD,PhD

Co-Investigator: Thomas Goss, MD

Grant Title: Preliminary study to identify osteoblastic cells in the peripheral circulation in mice.

Grant Funded by: OTA

Principal Investigator: Richelle Carrie Takemoto, MD

Co-Investigator: Kenneth A. Egol, MD

Grant Title: Quantitative Assessment of Osteogenic Genes and Proteins from Alternate Bone-
Graft Harvesting Sites.

Grant Funded by: OTA

Principal Investigator: Sarah R. Zawodny, MD

Co-Investigator: Quanjun Cui, MD

Grant Title: Osteotropic Peptides: Therapy for Post-traumatic Osteonecrosis of the Femoral Head
Grant Funded by: OTA

2009

January 1, 2009 – December 31, 2009 Grant Cycle

$10,000 Resident Grant Recipients

Principal Investigator: Jaimo Ahn, MD, PhD Amount Funded: $10,000
Co-Investigator: Joseph Bernstein, MD, MS

Grant Title: Harnessing Collective Intelligence for the Management of Subcapital Hip Fractures

Principal Investigator: Arun Aneja, MD Amount Funded: $10,000

Co-Investigator: George Russell, MD

Grant Title: Inflammatory Response to Trauma in the Obese

Principal Investigator: Erik Hansen, MD Amount Funded: $10,000

Co-Investigator: Utku Kandemir, MD

Grant Title: Measurement of Tissue Oxygenation for Diagnosis of Acute Compartment Syndrome following Tibia Fracture: A Pilot Study

Principal Investigator: Raj Kakarlapudi, MD Amount Funded: $10,000

Co-Investigator: Brett Crist, MD

Grant Title: Osteogenic Cell Viability in Bone Graft Obtained in Reamer Irrigator and Aspirator (RIA) System Versus Iliac Crest Bone Graft

Principal Investigator: Ethan Kellum, MD, MS Amount Funded: $10,000

Co-Investigator: Michael Tucker, MD

Grant Title: The effects of suramin treatment on fracture healing and muscle regeneration in a rodent model

Principal Investigator: James Starman, MD Amount Funded: $10,000

Co-Investigator: Michael Bosse, MD

Grant Title: Foreign-body Induced Biomembranes in Segmental Bone Defects: Histologic, Immunohistochemical, and Gene Expression Properties in a Rat Model

Principal Investigator: Aaron Nauth, MD Amount Funded: $10,000

Co-Investigator: Emil Schemitsch, MD FRCSC

Grant Title: Effect of Mesenchymal Stem Cell-Based Gene Transfer of VEGF and eNOS on Healing of a Segmental Bone Defect

Principal Investigator: Matthew Futvoye, MD Amount Funded: $10,000

Co-Investigator: George Russell, MD

Grant Title: Vacuum assisted closure of acetabular fracture incisional wounds in the obese.

Principal Investigator: Thomas Jones, MD Amount Funded: $10,000

Co-Investigator: Laura Prokuski, MD

Grant Title: Sterility of Intraoperative Irrigation

Principal Investigator: Tamara Pylawka, MD Amount Funded: $10,000

Co-Investigator: Spence Reid, MD

Grant Title: Characterization of the Interface between Neocartilage Produced by Nonarticular Chondrocytes and the Subchondral Bone

2008

Clinical Grant Applications (up to $40,000/year, 2 year grant cycle)

Title of Grant
“A Multicenter Randomized Clinical Trial of Non-operative versus Operative Treatment of
High-grade, Acute Acromio-clavicular Joint Dislocation”
Grant Funded by: OTA/Synthes

Principal Investigator: Michael McKee, MD, FRCS(C.)

Co-Investigator: Guy Pierre, MD, FRCS(C.)

Amount and Date Funded:
$50,000 (3-year grant cycle)
Presentations:

Publications:

Additional Grants and Awards: None

Project Status: This multi-centered trial is ongoing. Currently there are 14 participating sites throughout Canada and the United States, each contributing patients for the study. Although enrollment has been slower than originally anticipated, the study is making progress and continues to gather vital data. Thus far we have enrolled 23 participants in the study. The study expects to continue enrollment until the target sample size is reached.

Title of Grant
“Cerebrospinal Fluid Cytokines as Biomarkers for Delirium Following Hip Fracture Repair in Elders”

Grant Funded by: OTA/Stryker Orthopaedics

Principal Investigator: Simon Mears, MD, PhD

Co-Investigator: Ronald Byank, MD

Amount and Date Funded:
$39,620 (year 1: $19,810 – year 2: $19,810)
Presentations:

Publications:

Additional Grants and Awards: None

Project Status: Ongoing.

Title of Grant

     “Intramedullary Nails versus Plate Fixation Re-Evaluation Study in Proximal Tibia Fractures:
     A Multicenter Rando mized Trial Comparing IM Nails and Plate Fixation (IMPRESS)”
Grant Funded by: OTA/Orthofix
Principal Investigator: Paul Tornetta, MD                                      Amount Funded: $80,000

Co-Investigator: Andrew Schmidt, MD (year 1: $39,500 – year 2: $40,500)

Title of Grant
     “A Study of Locked Plates versus Intramedullary Nails in Distal Femur Fractures:
       A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation (SOLVED)”
Grant Funded by: OTA/AO North America & Smith and Nephew

Principal Investigator: Paul Tornetta, MD Amount Funded: $80,00
Co-Investigator: William Ricci, MD (year 1: $39,500 – year 2: $40,500)

rhBMP-2 ($65,000/year, 2 - 3 year funding cycle)

Title of Grant
“RhBMP2 vs. Autograft for Critical Size Tibial Defects: A multi-center randomized trial”
Grant Funded by: OTA/Medtronic

Principal Investigator: Lisa Cannada, MD

Co-Investigator: Paul Tornetta, MD (2-year grant cycle)

Amount and Date Funded:
$63,494

Presentations:

Publications:

Additional Grants and Awards
This study served as one of the 3 main projects for the Major Extremity Trauma Research Consortium (METRC) which received a collective $18.4 million dollar grant from the Department of Defense over a 5 year period.

Project Status

Ongoing.

Basic Research Grants (up to $25,000, 1 year grant cycle)

Title of Grant
“Objective Assessment of Fracture-Associated Soft Tissue Injury Using CT-Based Texture Analysis”

Grant Funded by: OTA/AO North America

Principal Investigator
Donald Anderson, PhD

Co-Investigator

J. Lawrence Marsh, MD

Amount and Date Funded:
$25,000
Presentations:

                54th Annual Meeting of the Orthopaedic Research Society - San Francisco, CA - March 2-5, 2008
          75th Annual Meeting of the AAOS - San Francisco, CA - March 5-9, 2009
              OARS! World Congress on Osteoarthritis 2008 - Rome, Italy - September 2008
              55th Annual Meeting of the Orthopaedic Research Society - Las Vegas, NV - February 22-25, 2009

Publications:

Ostearthritis and Cartilage - September 2008; 16(Supp 4)

Additional Grants and Awards

None. Pending grant - Army/PRORP Hypothesis Development Award/Sept. 15, 2009 submitted.

Project Status

Ongoing.

Title of Grant
“Trans-sacral/Alar Screw Fixation for Comminuted Transforaminal Sacral Fractures”

Grant Funded by: OTA/Biomet Trauma
Principal Investigator: Brett Crist, MD Amount Funded: $25,000

Co-Investigator: Gregory Della Rocca, MD, PhD

Title of Grant
“Real-Time In Vivo Profiling of Vascular Endothelial Growth Factor Receptor 2 Expression
During Bone Healing in Living Mice”

Grant Funded by: OTA/Biomet Trauma

Principal Investigator: Philipp Mayer-Kuckuk, PhD Amount Funded: $25,000

Co-Investigator: Joseph Lane, MD

Title of Grant
“Efficacy and Safety of Covalently Bonded Silver External Fixation Pins”

Grant Funded by: OTA/Stryker Orthopaedics

Principal Investigator: Greg Merrell, MD Amount Funded: $25,000

Co-Investigator: Michael Medvecky, MD

Resident Grants 2008- 2009

January 1, 2008 – December 31, 2008 Grant Cycle

Title of Grant:
Antibiotic Prophylaxis in Orthopaedic Traumatology: A Prospective, Randomized Trial of
Duration of Administration

Grant Funded by: OTA/FOT

Principal Investigator: David Greenberg, MD

Co-Investigator: Brett Crist, MD

Amount and Date Funded:
$10,000 January 2008
Presentations

None
Additional Grants and Awards

None

Project Status
2008-Extension approved.
2009 - Data collection is ongoing. Anticipation of 1-2 years prior to completion.

Principal Investigator: Marc Fajardo, MD Amount Funded: $10,000

Co-Investigator: Kenneth Egol, MD

Grant Title: Analysis of Long Bong Fracture Nonunion
by an expression profile of the Matrix Metalloproteinases
and ADAMTS enzyme families: a prospective study

Grant Funded by: OTA/FOT

Title of Grant
Axial CT Evaluation of the Distal Tibiofibular Syndesmosis
Grant Funded by: OTA/FOTA

Principal Investigator: Gregory Dikos, M.D

Co-Investigator: Timothy Weber, M.D

Amount and Date Funded:
$10,000 January 1, 2008 - December 31, 2008
Presentations

32nd Annual Garceau-Wray Lectureship June 2008 - Indiana University School of Medicine
25th Annual OTA Meeting Poster - October 2009 - San Diego, California
Publications

Not yet submitted. Manuscripot in preparation for submission to JOT.

Additional Grants and Awards

Methodist Research Institute Grant - $10,000 Cycle: 1/1/2008 - 12/31/2008
Indiana University Foundation Grant - $2,000 Cycle: 1/1/2008 - 12/31/2008

Project Status
2009- Ongoing

Principal Investigator: Safdar Khan, MD Amount Funded: $10,000

Co-Investigator: Mark Lee, MD

Grant Title: Does Leptin Modulate Fracture Healing
After Traumatic Brain Injury?

Grant Funded by: OTA/FOT

Principal Investigator: Alexis Dang, MD Amount Funded: $10,000

Co-Investigator: Theodore Miclau, MD

Grant Title: Effects of FGF-2 and BMP-7 on
articular injuries in rabbits

Grant Funded by: OTA/FOT

Title of Grant
”Ultrasound for the Use of Predicting Union After Tibia Fractures Treated with Reamed
Intramedullary Interlocked Nails
Grant Funded by: OTA/Medtronic
Principal Investigator: Adam Rana, MD

Co-Investigator: Paul Tornetta, MD

Amount and Date Funded:
$10,000 January 1, 2008 - December 31, 2008
Presentations

OTA Annual Meeting, 25th Anniversary Meeting, San Diego - Oct. 8-10, 2009

Publications: None

dditional Grants and Awards: None

Project Status: 2009- Ongoing

Principal Investigator: James Meeker, M.D. Amount Funded: $10,000

Co-Investigator: Laurence Dahners, M.D.

Grant Title: The effect of nitric oxide on
intramedullary vascularity and fracture healing

Grant Funded by: OTA/Medtronic

Grant Title: The Effects of Hypothermia and Mediators on Skeletal muscle Function Following
Ischemia-Reperfusion injury

Principal Investigator: Daniel Stahl, MD

Co-Investigator: Robert Probe, MD
Grant Funded by: OTA/Medtronic

Amount and Date Funded:
$10,000 January 1, 2008 - December 31, 2008
Presentations

None

Publications

None

Additional Grants and Awards

None

Project Status
2009-Project Concluded.

Principal Investigator: Ajay Manjoo, MD Amount Funded: $10,000

Co-Investigator: David Sanders, MD

Grant Title: Effect of Timing of Indomethacin
Administration on Cell Damage due to Elevated
Compartment Pressure: An Intravital Videomicroscopy
Study in Rats

Grant Funded by: OTA/Medtronic

Principal Investigator: Eric Eisner, MD Amount Funded: $10,000

Co-Investigator: Joseph Borrelli, MD

Grant Title: The Mechanism for Chondrocyte
Apoptosis Following Mechanical Injury

Grant Funded by: OTA/AO North America

Principal Investigator: Susan Tseng, MD Amount Funded: $10,000

Co-Investigator: Mark Lee, MD

Grant Title: The Use of Bone Marrow-Derived
Mesenchymal Stem Cells in the Prevention and
Treatment of a Rat Atropic Nonunion Model

Grant Funded by: OTA/AO North America

Principal Investigator: Aaron Chamberlain, MD Amount Funded: $10,000

Co-Investigator: Robert Dunbar, MD

Grant Title: Medial vs. Anterolateral Plating of
Extraarticular Distal Tibial Fractures (AO/OTA 43A):
A Biomechanical Analysis

Grant Funded by: OTA/Smith & Nephew Orthopaedics

Principal Investigator: Mark Stouffer, MD Amount Funded: $10,000

Co-Investigator: Michael Prayson, MD

Grant Title: Comparison of short and long
Cephalomedullary nail in treatment of unstable
intertrochanteric hip fractures-Biomechanical study

Grant Funded by: OTA/Smith & Nephew Orthopaedics

Resident Grants 2008- 2009

June 1, 2008 – May 31, 2009 Grant Cycle

Principal Investigator: Brooke Ballard, M.D. Amount Funded: $10,000

Co-Investigator: Alexandra Schwartz, M.D.

Grant Title: Effect of Tibial Plateau Fracture on Synovial Fluid Lubrication Function and Constituents
Grant Funded by: OTA/AO North America

Principal Investigator: James Halloran, MD Amount Funded: $10,000

Co-Investigator: Edward Harvey, MSc, MD, FRCSC

Grant Title: Can the Use of Polyaxial Distal Radius Locking Plates Compensate for Suboptimal Plate Position?
Grant Funded by: OTA/AO North America

Title of Grant
Ulnar Neck Fractures: A Biomechanical Study

Grant Funded by: OTA/AO North America

Principal Investigator
Jerod Hines, MD

Co-Investigator

Max Talbot, MD, FRCS

Amount and Date Funded:
$10, 000
Presentations:

None

Publications:

None

Additional Grants and Awards

Project Status

Ongoing. 2009 update: Awaiting the hardware for testing.

Principal Investigator: Kyle Kokko, MD, PhD Amount Funded: $10,000

Co-Investigator: Langdon Hartsock, MD

Grant Title: Acceleration of Fracture Healing by Novel Polypeptides
Grant Funded by: OTA/AO North America

Principal Investigator: J. Melvin, MD Amount Funded: $10,000

Co-Investigator: Samir Mehta, MD

Grant Title: A Prospective Evaluation of Brain Oxygenation and Neurologic Outcomes After Intramedullary Nailing in Patients with Long Bone Fratcures and Head Injury.
Grant Funded by: OTA/AO North America

Principal Investigator: Jonathan Schoenecker, MD, PhD Amount Funded: $10,000

Co-Investigator: William Obremskey, MD, MPH

Grant Title: Role of PAR-2 in Fracture Healing
Grant Funded by: OTA/AO North America

Title of Grant
Efficacy and Dose Evaluation of TPO in Healing Critical-Sized Femoral Defects

Grant Funded by: OTA/AO North America

Principal Investigator
Jonathan Wilhite, MD

Co-Investigator

Jeffrey Anglen, MD

Amount and Date Funded:
$10, 000
Presentations:

Anticipated Indiana Orthopedic Society - May 2010
Anticipated Indiana University Garceau Wray Lectureship - June 2010

Publications:

Pending Publications: JOR/JOT (Date submitted 07/2010)

Additional Grants and Awards
NIH R21 or R01 anticipated (Date submitted 10/2010)

Project Status

Ongoing. 15 week timepoint is still ongoing (as of Dec. 2009) Data is supporting hypothesis.

2007

Clinical Grant Applications (up to $40,000/year, 2 year grant cycle)

Title of Grant
“Dynamic Hip Screw vs. Trochanteric Fixation Nail in the Treatement of Intertrochanteric
Hip Fractures”

Grant Funded by: OTA/DePuy, a Johnson & Johnson Company

Principal Investigator: Rudolph Reindl, MD Co-Investigator: Edward J. Harvey, MD

Amount and Date Funded:
$80,000 (2-year grant) ($40,000 - 2007, $40,000 - 2008)
Presentations

Canadian Orthopaedic Association Meeting, Quebec City - June 2008
(Results of pilot study).
Publications - None

Additional Grants and Awards
2007 Synthes Research Grant
Amount Awarded - $20,000.00
2008 Synthes Research Grant
Amount Awarded - $20,000.00

Project Status
2008-Ongoing

Title of Grant

“A Prospective Randomized Trial Comparing Open Reduction and Internal Fixation, Non-Spanning External Fixation, and Closed Reduction with Percutaneous Fixation in Displaced Distal Radius Fractures with Joint Congruity”

Grant Funded by: OTA/Zimmer

Principal Investigator: Gregory K. Berry, MD
Co-Investigator: Hans J. Kreder, MD

Amount and Date Funded:
$80,000 (2-year grant) ($40,000 - 2007, $40,000 - 2008)
Presentations

                Boston OTA/COTS (Update)              Oct. 2007
                Quebec OTA/COTS (Update)            June 2008
                Quebec OCCG (Update)                    June 2008

Publications - None.

Additional Grants and Awards

AIOD (anticipated funding) – 1 year $45, 000 grant.

Project Status
2008-Ongoing and is now multi-study. Six out of eight centers actively recruiting. Extension requested. Completion of patient enrollment in 2010, one year later than forseen.

Title of Grant
“Outcomes of Femur Fractures: RIA versus Standard Reaming”

Grant Funded by: OTA/Biomet Trauma

Principal Investigator
Kyle J. Jeray, MD

Co-Investigator

J. Scott Broderick, MD

Amount and Date Funded:
$80,000 $40,000 - 2007, $40,000 – 2008 (2 year Grant)
Presentations

None at this time.

Publications

None at this time.
Additional Grants and Awards

Synthes supply grant. In process of obtaining additional funding to hire Clinical Research Assistant.

Project Status
2008 - Ongoing, open and actively enrolling patients. Currently 45 patients enrolled. This grant is currently funding a multi-center study entitled “Standard Reaming versus Reaming/Irrigating/Aspirating for Intramedullary Nailing of Femoral Shaft Fractures (S.T.A.F.F.).

Directed Topic Clinical Study: (up to $50,000/year, 3 year funding cycle)

Title of Grant:

“Timing of Orthopaedic Surgery in the Multiply-injured Patient: Development of a
Protocol for Early Appropriate Care”
Grant Funded by: OTA/Smith & Nephew/Medtronic
Principal Investigator: Heather A. Vallier, MD Amount Funded: $150,000 (3-year grant)

Co-Investigator: John Howard Wilber, MD ($50,000/yr 2007 - 2009)

Amount and Date Funded:
$150,000 – 3 year grant $50,000/yr 2007-2009
Presentations

OTA Annual Meeting, October 2008
AAOS Annual Meeting, February 2009

Publications

Expecting several publications over the next 2-3 years.

Additional Grants and Awards

None

Project Status
2008-Ongoing

Basic Research Grants (up to $25,000, 1 year grant cycle)

Title of Grant
            “Can we eliminate the need for autologous bone graft harvest for fracture management?
             The use of multipotential adipose derived stromal cells in an activated matrix
             for in vivo osteogenesis”

Grant Funded by: OTA/Synthes, USA

Principal Investigator: Francis H. Shen, MD

Co-Investigator: Shepard R. Hurwitz, MD

Amount and Date Funded:
$25,000 January 2007
Presentations

International Society for the Study of the Lumbar Spine, June 2007

Sixth Combined Meeting of the Orthopaedic Research Society, October 2007

Publications

2008- Pending Publication, A Novel Reproducible Animal Model Simulation Vertebral Body Defect Repair

Additional Grants and Awards

National Osteoporosis Foundation- $50,000, July 2007-June 2008

Project Status
2008-Ongoing

Title of Grant:
“Effect of Delayed Surgery on Infection Rate of Open Fractures in a Rabbit Model”

Grant Funded by: OTA/Stryker Orthopaedics

Principal Investigator: Langdon A. Hartsock, MD Amount Funded: $25,000

Co-Investigator: Yuehuei An

Amount and Date Funded:
$25,0000 January 2007
Presentations

                Southern Orthopaedic Association – February 2008
                South Carolina Orthopaedic Association – July 2008
                MUSC Orthopaedic Siegling Society Research Day    - April 2008

Publications

Pending – Journal of Orthopaedic Trauma (plans to submit)

Additional Grants and Awards

NIH ROI (not submitted yet)

Project Status
2008 – Project complete. Plans to submit future grant application for additional

research.

Title of Grant
“Effects of rhBMP-7 on Fracture Healing in an Ischemic Environment”
Grant Funded by: OTA/AO North America
Principal Investigator: Chuanyong Lu, MD

Co-Investigator: Theodore Miclau, III MD

Amount and Date Funded:
$25,000 January 2007
Presentations

ORS 54^th Annual Meeting, March 2008

OTA Annual Meeting, October 2008

Publications

None

Additional Grants and Awards

None

Project Status
2008- Ongoing

Title of Grant
“Segmental Defect Regeneration Using Biodegradable Load-Bearing BMP-2
Carriers in a Canine Model”
Grant Funded by: OTA/Medtronic
Principal Investigator: Rena L. Stewart, MD

Co-Investigator: Tien-Min Chu

Amount and Date Funded:
$25,000 January 2007
Presentations

Orthopaedic Research Society Meeting- March 2008

Combined AOA/COA Meeting- June 2008

OTA Annual Meeting- October 2008

Publications

Will be submitted fall 2008 for publication to the Journal of Trauma

Additional Grants and Awards

OREF/Zimmer Career Development Grant- $50,000 (2008-2009)

Project Status
2008- Project Completed

Resident Grants 2007- 2008

June 1, 2007 – May 31, 2008 Grant Cycle

Title of Grant:
“The Role of Sensory Nerve Function and Fracture Healing”

Grant Funded by: OTA

Principal Investigator: Peter Apel, MD

Co-Investigator: Robert Teasdall, MD

Amount and Date Funded:
$10,000 June 2007
Presentations

Additional Grants and Awards

Project Status
2008-Extension approved.

Title of Grant
“The Use of Osteogenic BMPs to Augment Healing of Critical Sized Femoral Defects in a Rat Model”

Grant Funded by: OTA

Principal Investigator: Matthew Beal, MD

Co-Investigator: Michael Stover, MD

Amount and Date Funded:
$10,000 June 2007
Presentations

None
Publications

None
Additional Grants and Awards

Project Status
2008-Ongoing/Extension approved.

Title of Grant
“Cytokine liberation from secondary surgery in the setting of the second hit syndrome”

Grant Funded by: OTA

Principal Investigator: Reed Estes, MD

Co-Investigator: David Volgas, MD

Amount and Date Funded:
$10,000 June 2007
Presentations

None
Publications

Pending submission to JOT

Additional Grants and Awards

None

Project Status
2008- Ongoing/Extension approved.
2009 - Completed

Title of Grant:
“Correlation of Health Outcome Measure Scores in Foot and Ankle Trauma”

Grant Funded by: OTA

Principal Investigator: Christina Goldstein, MD

Co-Investigator: Bradley Petrisor, FRCSC

Amount and Date Funded:
$10,000 June 1, 2007
Presentations

None
Publications

None

Additional Grants and Awards
None

Project Status
2008-Extension approved. Manuscript currently in preparation, not yet submitted.

Title of Grant:
“Relative Effect of Cephalomedullary Nails Versus Sliding Hip Screw in the Treatment of Peri-trochanteric Hip Fractures on Mortality and Re-operation in a Community-Based Clinical Setting”

Grant Funded by: OTA

Principal Investigator: Saam Morshed, MD, MPH

Co-Investigator: Theodore Miclau, MD

Amount and Date Funded:
$10,000 June 1, 2007

Presentations

Publications

Additional Grants and Awards

Project Status
2008-Extension approved. No update report received.

Title of Grant:
“Time of Exposure to C-arm Drape Contamination”
Grant Funded by: OTA
Principal Investigator: Paul Peters, MD

Co-Investigator: Michael Prayson, MD

Amount and Date Funded:
$10,000 June 1, 2007
Presentations

            American Academy of Orthopaedic Surgeons (Poster)                  March 2008                            Mid-America Orthopaedic Association (Podium)                                               April 2008
OTA Annual Meeting Poster                                                                              October 2008
AAOS Podium Presentation, 2008/2009 because it was nominated for being one of the top resident papers at MAOA meeting in April, 2008
Publications
            Plans to submit paper for publication in the JOT or the JBJS.

Additional Grants and Awards

None

Project Status – Concluded

Grant Title:
“Operative vs. Non-operative Treatment of Ligamentous SER-4 Ankle Fractures: A Prospective,

Randomized Study

Grant Funded by: OTA

Principal Investigator: Nelson Saldua, MD
Co-Investigator: Michael Mazurek, MD

Amount and Date Funded:
$10,000 June 1, 2007
Presentations
None
Publications

None

Additional Grants and Awards

Project Status
2008 - Ongoing.

Title of Grant
“Biomechanical Analysis of a New Locked Plating System for the Proximal Humerus”

Grant Funded by: OTA

Principal Investigator: Ross Schumer, MD
Co-Investigator: Michael Prayson, MD

Amount and Date Funded:
            $10,000                                     June 1, 2007
Presentations
            Military meeting, Las Vegas, December 2008
            AAOS Specialty Day, Las Vegas February 2009
            Mid America meeting, April 2009
          Ohio Orthopaedic Society May 2009
Publications
              2010 anticipated publication date – Journal of Shoulder & Elbow Surgery

Additional Grants and Awards

Project Status
2008 – Completed.

Title of Grant
“The Effect of Donor Age on the Healing Potential of (h)BMP-2-expressing, Adipose-Derived
Multi-potential Progenitor Cells in the Young-Adult Rat Segmental Femur Defect Model”|
Grant Funded by: OTA|
Principal Investigator: Patrick Whitlock, MD, PhD
Co-Investigator: Lawrence X. Webb, MD

Amount and Date Funded:
$10,000 June 1, 2007
Presentations
None
Publications

None
Abstract Submissions:
1. Abstract OTA 2010 Annual Meeting, Baltimore
2. Abstract 2010 Challenges in Fracture Care Across Disciplines, Phoenix, AZ

Additional Grants and Awards

None (Pending grants - AO North America)

Project Status
2008 – Project ongoing. Grant extension approved.
2010 - Project ongoing.

Title of Grant
“The Effect of Sacral Fracture Malreduction on the Strength of Iliosacral Screw Fixation for
Transforaminal Sacral Fractures

Grant Funded by: OTA

Principal Investigator: Jason Young, MD

Co-Investigator: Michael Stover, MD

Amount and Date Funded:
$10,000 January 2007
Presentations

None
Publications

None
Additional Grants and Awards

None
Project Status
2008- Research extended one year.

Resident Grants 2007

January 1, 2007 – December 31, 2007 Grant Cycle

Title of Grant
“Gait Analysis after Retrograde and Antegrade Intramedullary Nail Fixation of
Femoral Shaft Fractures”

Grant Funded by: OTA/Foundation for Orthopaedic Trauma
Principal Investigator: Sara Strebe, MD

Co-Investigator: Lisa Cannada, MD

Amount and Date Funded:
$10,000 January 2007
Presentations

In progress

Publications

Expecting/pending publications

Additional Grants and Awards None

Project Status
2008-Ongoing
2009 - Ongoing - still recruiting patients.

Title of Grant
“Utilizing Nanospheres to Transport Antibiotics Across the Cell Membrane to Kill Intracellular
Staphylococcus Aureus”

Grant Funded by: OTA/ Foundation for Orthopaedic Trauma

Principal Investigator: John Ellington, MD, MS Amount Funded: $10,000

Co-Investigator: Michael Bosse, MD

Amount and Date Funded:
$10,000 January 2007
Presentations
North Carolina Nano Biotechnology Research Award, July 2007

Publications
Res. Soc. Symp. Proc. Mater, Vol. 1019, 2007

Additional Grants and Awards
Yes - 3 pending: 1. Aircast Foundation (98k), NCBC (258k),
Dept of Defense (2.5 million)
Project Status
2008 – Project Concluded

Title of Grant
“Blinding of Outcome Assessors in Clinical Trials of Orthopaedic Trauma”

Grant Funded by: OTA/ Foundation for Orthopaedic Trauma

Principal Investigator: Paul Karanicolas, MD Amount Funded: $10,000

Co-Investigator: Mohit Bhandari, MD, MSc

Amount and Date Funded:
$10,000 January 2007
Presentations
Inter-observer reliability of classification systems to rate the quality of femoral neck fracture reduction. Orthopaedic Trauma Association (OTA) Annual Meeting. Denver, USA. Oct. 15-18, 2008.

A Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. Orthopaedic Trauma Association (OTA) Annual Meeting. Denver, USA. Oct. 15-18, 2008.

Blinding of Outcomes in Trials of Orthopaedic Trauma: An Opportunity to Enhance the Validity of Clinical Trials. International Society for Fracture Repair. July 2008.

A Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. International Society for Fracture Repair. July, 2008.

Inter-observer reliability of classification systems to rate the quality of femoral neck fracture reduction. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008.

Blinding of Outcomes in Trials of Orthopaedic Trauma: An Opportunity to Enhance the Validity of Clinical Trials. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008.

A Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008 (Poster Award).

Publications

The Journal of Orthopaedic Trauma 23(6):408-12, July 2009
The Journal of Clinical Epidemiology 62(2):214-223, Feb 2009
The Journal of Bone and Joint Surgery - American volume. 90(5):1026-33, May 2008.

Additional Grants and Awards
None.

Project Status
2008 – Financial Report Received.
2009 - Concluded.

Title of Grant
“The Pathophysiology of Compartment Syndrome: Intracompartmental Pressure, Skeletal Muscle
Viability and Microcirculatory Changes”

Grant Funded by: OTA/ Foundation for Orthopaedic Trauma

Principal Investigator: Abdel Rahman Lawendy, MD Amount Funded: $10,000

Co-Investigator: David Sanders, MD

Amount and Date Funded:
$10,000 January 2007
Presentations
Publications

Additional Grants and Awards

Project Status
2008 – No report received.

Grant Title
“The Effect of Obesity on Outcomes Among Trauma Patients with
Lower Extremity Orthopaedic Injuries”

Grant Funded by: OTA/ Foundation for Orthopaedic Trauma

Principal Investigator: Rajshri Maheshwari, M.D. Amount Funded: $10,000

Co-Investigator: Sean Nork, M.D.

Amount and Date Funded:
$10,000 January 1, 2007
Presentations

                AAOS 75^th Annual Meeting, San Francisco, CA                             March 2008
            Ruth Jackson Orthopaedic Society Biennial Meeting      October 2007
            North Pacific Orthopaedic Society 82^nd Annual Meeting                  September 2007
            University of Washington Resident Research Days                        June 2007
Publications

Pending – Journal of Orthopaedic Trauma – Revisions submitted July 2008

Additional Grants and Awards

OREF/Depuy Orthopaedic Resident Research Grant $5,000 (1 year)
Frank B. Smith Memorial Award Paper $1,000

Title of Grant
“The Effect of Nitric Oxide on Intramedullary Vascularity and Fracture Healing”

Grant Funded by: OTA

Principal Investigator: James Meeker, M.D. Amount Funded: $10,000

Co-Investigator: Laurence Dahners, M.D.

Amount and Date Funded:
$10,000 January 2007
Presentations

Publications

Additional Grants and Awards

Project Status
2008 – No update received.

Publications
Journal of Orthopaedic Research, 2006; 24(4):645-652

Additional Grants and Awards

Project Status

Project Concluded.

Title of Grant

“Do Variations in Pulsatile Lavage Pressure Affect Cancellous Bone Structure and

Fracture Healing”

Grant Funded by: OTA/Stryker Howmedica Osteonics

Principal Investigator

Douglas R. Dirschl, MD

Amount and Date funded

$19,872 January 2002

Presentations

None

Publications

Journal of Orthopaedic Trauma, 2006, 20:261-266

Additional Grants and Awards

None

Project Status

Animal surgery finished 5/02. Data analysis ongoing.

2003 – Project concluded.

Title of Grant

“Use of Direct BMP-2 Gene Delivery to Enhance the Healing of Segmental Bone

Defects: Evaluation in a Rat Model”

Grant Funded by: OTA/Synthes

Principal Investigator

Christopher H. Evans, MD

Amount and Date funded

$20,000 January 2002

Presentations

Orthopaedic Research Society, 2003 (New Orleans)

Publications

Journal of Bone & Joint Surgeons, vol. 88-A #2, Feb. 2006

Additional Grants and Awards

Based upon the preliminary data obtained with our OTA grant, we have secured a 5-year RO1 grant from NIAMS (AR 050243)

Project Status

2002 - Work has been in progress for 7 months, and great data is being received.

However, it is too soon to publish or present, or secure further funding.

Project Concluded.

Title of Grant

“Comparison of IMN vs. Cast in Stable Tibia Fractures”

Grant Funded by: OTA/DePuy Ace

Principal Investigator

William T. Obremskey, MD

Amount and Date funded

$48,377 January 2002

Presentations

OTA Annual Meeting, Oct. 2006

Publications

Journal of Orthopaedic Trauma, Dec. 2007 (pending)

Additional Grants and Awards

None

Project Status

Animal surgery finished 5/02. Data analysis ongoing.

2005 – Project ongoing.

2006 – Project ongoing.

2008 – Project complete.

Title of Grant

“Study to Prospectively Evaluate Reamed Intramedullary Nailing in Tibial Fractures: A

Multi-Center Randomized Trial”

Grant Funded by: OTA/AO North America

Principal Investigator

Gordon Guyatt, MD

Amount and Date funded

$50,000 January 2002

Presentations

AAOS Annual Meeting, San Francisco, California, March 2004

Publications - Controlled Clinical Trials, 2003
Sprint Manuscripts Accepted for Publication

S.P.R.I.N.T. Investigators. Randomized Trial of Reamed versus Non-Reamed Intramedullary Nailing of Tibial Shaft Fractures. J Bone Joint Surg Am. In Press, December 2008.

S.P.R.I.N.T. Investigators. Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients with Tibial Fractures (S.P.R.I.N.T.): Study Rationale and Design. BMC Musculoskelet Disord. 2008, 9:91 (23 Jun 2008). *Recipient of the International Society for Fracture Repair (ISFR) 2008 Best Paper Award.

Presented SPRINT Abstracts

S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Orthopaedic Trauma Association (OTA) 23^rd Annual Meeting, Boston, MA, October 2007.

S.P.R.I.N.T. Investigators. (Tornetta, P). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Functional Outcome in Patients with Fractures of the Tibia. Orthopaedic Trauma Association (OTA) 23^rd Annual Meeting, Boston, MA, October 2007.

S.P.R.I.N.T. Investigators. (Bhandari, M). Reamed versus Non-Reamed Tibial Intramedullary Nail Insertion on Re-operation Rates. American Academy of Orthopaedic Surgeons (AAOS) 75^th Annual Meeting, San Francisco, CA, March 2008.

S.P.R.I.N.T. Investigators. (Sanders, D). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. American Academy of Orthopaedic Surgeons (AAOS) 75^th Annual Meeting, San Francisco, CA, March 2008.

S.P.R.I.N.T. Investigators. (Swiontkowski, MF). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Mid-American Orthopaedic Association 26^th Annual Meeting, Champions Gate, FL, April 2008.

S.P.R.I.N.T. Investigators. (Goslings, JC). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Functional Outcome in Patients with Fractures of the Tibia. Dutch Association for Trauma Surgery Annual Meeting, Netherlands, November 2007.

S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Canadian Orthopaedic Association (COA) 63^rd Annual Meeting, Quebec City, QC, June 2008.

S.P.R.I.N.T. Investigators. (Schemitsch, E). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. Canadian Orthopaedic Association (COA) 63^rd Annual Meeting, Quebec City, QC, June 2008.

S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. 81^st Annual Congress of the Japanese Orthopaedic Association, Sapporo, Japan, May 2008.

S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) 9^th Annual Congress, Nice, France, May/June 2008.

S.P.R.I.N.T. Investigators. (Bhandari, M). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) 9^th Annual Congress 2008, Nice, France, May/June 2008.

S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. International Society for Fracture Repair (ISFR) Biennial Meeting 2008, Lake Tahoe, CA, July 2008.

S.P.R.I.N.T. Investigators. (Bhandari, M). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. International Society for Fracture Repair (ISFR) Biennial Meeting 2008, Lake Tahoe, CA, July 2008.

Accepted SPRINT Abstracts

S.P.R.I.N.T. Investigators. (Busse, J). A Comparison of the Discriminative Ability and Responsiveness of the Short Musculoskeletal Function Assessment Questionnaire Function Index and the Short Form-36 Physical Summary Score among Tibial Fracture Patients. Orthopaedic Trauma Association (OTA) Annual Meeting 2008, Denver, CO, October 2008.

Additional Grants and Awards

Grant/Award Title: OREF – for Sprint Economic Analysis

Amount Awarded: $100,000

Funding Cycle: July 2005 – June 30, 2007
Grant/Award Title: Canadian Institute of Health Research

Amount Awarded: $499,952 ($CAN)

Funding Cycle: April 2004 – March 2007

Grant/Award Title: National Institute of Health

Amount Awarded: $980,940

Funding Cycle: May 2002 –2005

Grant/Award Title: Canadian Institute of Health Research

Amount Awarded: $701,533 ($CAN)

Funding Cycle: April 2001 – March 2004

Grant/Award Title: Orthopaedic Research & Education Foundation

Amount Awarded: $100,000

Funding Cycle: July 2002 –2004

Grant/Award Title: Zimmer Orthopaedics

Amount Awarded: $34,125 ($CAN)

Funding Cycle: December 2000 – 2001

Grant/Award Title: Hamilton Health Sciences Corporation

Amount Awarded: $25,000 ($CAN)

Funding Cycle: October 2000 – 2001

Grant/Award Title: Medical Research Council

Amount Awarded: $90,988 ($CAN)

Funding Cycle: April 2000 – March 2001

Project Status

Project is still recruiting patients, and will not be completed until 2005.

2003 – Requested additional funding from CIHR for Canadian centers.

2004 – Project On-going. Several publications expected.
2005 – Recruitment has stopped, currently following patients.

2006 – Pending publications to be determined 2007 – Completed patient follow-up in 2006 - Primary paper draft completed with intent to submit it to journals in September
2008 – Update of the numerous publications and presentations resulting from this study record above. Continuing to conduct secondary analyses and expect additional publications and presentations over the next year.

Title of Grant

“Enhancement of Fracture Healing and BMP Induced Bone Formation by Traumatic

Brain Injury”

Grant Funded by: OTA/Synthes

Principal Investigator

Uwe Scherbel, MD

Amount and Date funded

$20,000 January 2002

Presentations

AAOS, February 2001; IBMS and ECTS, June 2001; OTA, October 2001 (poster);
OTA, October 2002 (poster)

Publications

Pending

Additional Grants and Awards

None

Project Status

2003 – Project ongoing.
2008 – No additional updates received.

Title of Grant

“Traumatic Brain Injury and Enhanced Osteogenic Potential in a Rat Model”

Grant Funded by: OTA/Zimmer

Principal Investigator

Paul Tornetta, III, MD

Amount and Date funded

$19,607 January 2002

Presentations

Orthopaedic Trauma Association, October 2004
AAOS Poster Presentation, February 2005

Publications

JBJS, 2007

Additional Grants and Awards

None

Project Status

2003 – ORS abstract submitted July 2003, manuscripts to be submitted to JOR or JBJS

upon completion (October).

2005 – Project Completed.

2001

Title of Grant

“A Multicenter, Prospective Randomized Trial of Non-operative and Operative
Treatment of Displaced Clavicular Shaft Fractures”

Grant Funded by: OTA/DePuy Ace, a Johnson & Johnson Company

Principal Investigator

Michael D. McKee, MD

Amount and Date funded

$20,000 January 2001

Presentations

Orthopaedic Trauma Association, October 2005

Publications

JBJS (A), January 2007

Additional Grants and Awards

Grant/Award Title: Zimmer Research Grant

Amount Awarded: $10,000

Funding Cycle: 2001 – 2003
2006 Specialty Day Edwin G. Bovill, Jr., MD Award

Project Status

2004 – 130 patients enrolled to date. Project concluded.

Title of Grant

“A Multicenter Prospective Randomized Trial of Open Reduction and Internal Fixation

vs. Total Elbow Arthroplasty for Severe Fractures of the Distal Humerus in Elderly

Patients”

Grant Funded by: OTA/Aventis Pharmaceuticals

Principal Investigator

Michael McKee, MD

Amount and Date funded

$20,000 January 2001

Presentations

OTA Annual Meeting, October 2006

Publications
JSES, 2007 (accepted for publication)

Additional Grants and Awards

Grant/Award Title: Zimmer Research Grant

Amount Awarded: $10,000 Funding Cycle: 2001 – 2003

OTA Edwin Bovill Award, 2007
ASES Neer Award, 2007

Project Status: Concluded.

Title of Grant

“Treatment of Displaced Femoral Neck Fractures in the Elderly: An Outcome Study of

Patient Prospectively Randomized to Internal Fixation, Hemiarthroplasty or Total Hip

Replacement.”

Grant Funded by: OTA/Zimmer

Principal Investigator

Kenneth Egol, MD

Amount and Date funded

$25,000 January 2001

Presentations

None

Journal of Bone and Joint Surgery American, November 2006