2011
OTA 2011 GRANT AWARDS
(Grant Cycle: January 1, 2011 – December 31, 2011) |
Directed Topic Clinical Study (up to $50,000/year, 3-year funding cycle)
(Surgical Infection Prevention and Treatment) |
Grant Title
Qualification and Susceptibilities of Microbial Flora in Open Fractures
Principal Investigator
Samir Mehta, MD
Co-Investigator
Paul Matuszewski, MD
Requested Funds
$80,000
Clinical Grants (up to $40,000/year, 2 year Grant Cycle) |
Grant Title
A Multicentre, Randomized Trial of Simple Decompression Versus Anterior Transposition of the Ulnar Nerve for Acute, Displaced Fractures of the Distal Humerus Treated With Plate Fixation
Principal Investigator
Emil Schemitsch, MD, FRCSC
Co-Investigator
Michael McKee, MD, FRCSC
Requested Funds
$78,630
Grant Title
A Multicentre, Randomized Trial of Conservative Treatment Versus Operative Plate Fixation for Acute, displaced Fractures of the Distal Clavicle
Principal Investigator
Jeremy Hall, MD, FRCSC
Co-Investigator
Michael Mckee, MD, FRCSC
Requested Funds
$80,000
Grant Funded by
COTA/Smith & Nephew
Grant Title
Randomized Clinical Trial of Suprapatellar Versus Infrapatellar Tibial Nailing
Principal Investigator
Roy Sanders
Co-Investigator
None Listed
Requested Funds
$38,680
Basic Research Grants (up to $25,000, 1 year Grant Cycle) |
Grant Title
The Use of Implantable Radio-Frequency Micomachnined Capacitive Sensor Chips to Monitor Compartment Pressures in the Lower Limb
Principal Investigator
Edward Harvey, MD, MSc
Co-Investigator
Vamsy Chodavarapu, PhD
Requested Funds
$18,517.50
Grant Title
Forceps Reduction of the Syndesmosis in Rotational Ankle Fractures: A Cadaveric Study and Prospective Case Series
Principal Investigator
Phinit Phisitkul,. MD
Co-Investigator
Larry Marsh. MD
Requested Funds
$25,000
Grant Funded by
COTA/Smith & Nephew
Grant Title
Effect of BMP-2 and MP-7 on Articular Cartilage Following Impact Load
Principal Investigator
Paul Chin, MD, PhD
Co-Investigator
Joseph Borellli, Jr., MD
Requested Funds
$25,000
Grant Funded by
Medtronic
Grant Title
The Effect of Late Type Endothelial Progenitor Cells on Augmentation of Angiogensis and Osteogensis in a Segmental Bone Defect Model
Principal Investigator
Ru Li, PhD
Co-Investigator
Emil Schemitsch, MD
Requested Funds
$25,000
Grant Funded by
COTA/Smith & Nephew
2010
OTA 2010 GRANT AWARDS
(Grant Cycle: January 1, 2010 – December 31, 2010) |
Directed Topic Clinical Study (up to $50,000/year, 3-year funding cycle)
(Proximal Humerus Fractures, Economic Outcomes in Trauma Care, Clinical Trial Re-evaluation of non-operative problems, Effect of non-operative post surgical therapy in trauma) |
Title of Grant
Decreasing Long Term Complications and Cost Following Hip Fracture using a Medical Home Concept (MHC)
Principal Investigator
Wade Smith
Co-Principal Investigator
Jove Graham
Requested Funds
$97,785
Presentations
None
Publications
None
Additional Awards and Grants
None
New Product or Patent
None
Pending Publications
OTA Abstract 2011 Annual Meeting, submitted February 2, 2011
Manuscript pending submission to JBJS, January 2012
Project Status
Ongoing
Clinical Grants (up to $40,000/year, 2 year Grant Cycle) |
Title of Grant
Multidisciplinary care of the geriatric patient with fractures below the hip
Principal Investigator
Gregory Della Rocca
Co-Principal Investigator
Yvonne Murtha
Requested Funds
$61,038
Presentations
None
Publications
None
Additional Awards or Grants
None
New Product or Patent
None
Project Status
Ongoing
Title of Grant
Prevalence of Abuse With An Intimate Partner Violence Surgical Evaluation (P.R.A.I.S.E.)
Principal Investigator
Brad Petrisor
Co-Principal Investigator
Mohit Bhandari
Requested Funds
$30,000
Title of Grant
Effects of the Presence of Microbial Biofilms on the Healing of Osseous Fractures Treated With Internal Fixation
Principal Investigator
Daniel Altman
Co-Principal Investigator
Greg Altman
Requested Funds
$75,000 (note: requested $80,000)
Basic Research Grants (up to $25,000, 1 year Grant Cycle) |
Title of Grant
Heterotopic Ossification in an Animal Extremity Blast Model
Principal Investigator
Robert O'Toole
Co-Principal Investigator
Vincent Pellegrini
Requested Funds
$25,000
Presentations
Maryland Orthopaedic Association, May 2010
American British Canadian Research Fellow Meeting, May 2010
Orthopaedic Trauma Association Meeting, October 2010
Publications
None
Additional Award and Grants
Department of Defense Research Grant
Amount Awarded
$600,000
Funding Cycle
09/2010 – 09/2013
New Product or Patent
None
Pending Publications
The Journal of Orthopaedic Trauma, January 2011
Project Status
Ongoing
Title of Grant
The Synergistic Effects of VEGF on BMP-induced Osteogenic Differentiation of Bone Marrow Stem Cells
Principal Investigator
Quanjun Cui
Co-Principal Investigator
Gary Balian
Requested Funds
$25,000
Title of Grant
Engineering the Bioactivity of Absorbable Magnesium Implants for Fracture Fixation and Bone Defect Scaffolds: The Effect of Calcium Phosphate Coatings on In-Vitro Biocorrosion and Osteogenic Differentiation of Mesenchymal Stem Cells.
Principal Investigator
Lawrence Bone
Co-Principal Investigator
Shuying Yang
Requested Funds
$25,000
Presentations
National Association of Corrosion Engineers Conference – March 2011
Society for Biomaterials Annual Meeting – April 2011
Publications
None
Project Status
Ongoing – Pending Publications:
Corrosion outcomes will be submitted to Biomaterials
Corrosion outcomes will be submitted to Biomaterials
Submitted
March 2011
May 2011
Additional Grants and Awards
R21 or R01 to NIAMS
Submitted
June 2011
Did this research grant lead to the development of a patent?
None
Project Status
No
Title of Grant
Endothelial Progenitor Cells for Healing and Angiogenesis in a Segmental Bone Defect Model: A Comparison With Mesenchymal Stem Cells
Principal Investigator
Aaron Nauth
Co-Principal Investigator
Emil Schemitsch
Requested Funds
$25,000
Title of Grant
Preferential Peroneal Nerve Palsy after Posterior Hip Dislocation and Acetabular Surgery: A Cadaveric Study
Principal Investigator
Ivan Tarkin
Co-Principal Investigator
Hans-Christoph Pape
Requested Funds
$25,000
Presentations
None
Publications
None
Additional Awards or Grants
None
New Product or Patent
None
Project Status
Ongoing
OTA 2010 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: January 1, 2010 – December 31, 2010) |
Title of Grant
Chitosan-Mediated FGF18 Delivery for Assisted Bone Repair
Principal Investigator
Alberto Carli, MD, C.M.
Co-Investigator
Edward J. Harvey, MD, CM
Title of Grant
The Efficacy and Cost Effectiveness of Preoperative and Postoperative Cryotherapy in Proximal Tibia Fractures
Principal Investigator
Jesse Alan Shantz, MD MBA
Co-Investigator
David Sanders, MD
Presentations
None
Publications
None
Additional Grants and Awards
OREF Orthopaedic Career Development Grant
Amount
$50,000
Funding Cycle
July 2010 – June 2011
New Product or Patent
None
Pending Publications
- Systematic Review of the Classification of Soft Tissue Injury in the Prospective Orthopedic Literature – Summer 2011
- Evaluation of Soft Tissue Injury in Proximal Tibia Fractures and Knee Dislocations: A Survey of the OTA and Knee Dislocations Study Group – Summer 2011
- The Efficacy and Cost Effectiveness of Pre-operative and Post-operative Cryotherapy in Proximal Tibia Fractures – Summer 2012
- The Development and Validation of a Novel Assessment Scale of Soft Tissue Injuries Associated with Proximal Tibia Fractures – Summer 2010
Project Status
Ongoing
Title of Grant
Tension Tension Band Wiring of Patella Fractures Separating Fact from Fiction- A Biomechanical Study
Principal Investigator
Eric R Henderson, MD
Co-Investigator
Henry Claude Sagi, M
Title of Grant
Expression of single nucleotide polymorphisms in delayed fracture healing
Principal Investigator
Vikram M Sathyendra, MD
Co-Investigator
John S. Reid, MD
Presentations
None
Publications
None
Additional Grants and Awards
None
New Product or Patent
None
Pending Grants
OTA Basic Research Grant
Submitted
February 8, 2011
Project Status
Ongoing
Title of Grant
The Effect of Low Magnitude Mechanical Signals on Tibial Shaft Fracture Healing
Principal Investigator
Roshan P Shah, MD, JD
Co-Investigator
Samir Mehta, MD
Title of Grant
The Comparison of the Therapeutic Potential of Isolated BMP-2 Producing Progenitor Cells, Bone Marrow Aspirates and Recombinant BMP-2 in Rodent Models of Bone Formation
Principal Investigator
Brandon M. Steen, MD
Co-Investigator
Thomas A. Einhorn, MD
Presentations:
Marsell R, Bais M, Steen B, Mortlock D, Gerstenfel LC, Einhorn TA. Skeletal Trauma Increases the Expression of Specific Mesenchymal Stem Cell Markers and Bone Morphogenetic Protein-2 in a Systemic Manner. Orthopaedic Research Society Meeting – January 2010
Publications
None
Additional Grants and Awards
Pending Grants – Submitted July 5, 2010.
Project Title: Role of Angiogenesis in Distraction Osteogenesis Application Number:1 R01
AR0566301 Pending percentile 13th.
Project Status
2009 – Ongoing, 2010 – Ongoing
Title of Gran
Tension Band Fixation of the Medial Malleous using Fiberwire. Suture: A Biomechanical Study
Principal Investigator
Ty Fowler, MD
Co-Investigator
Kevin J. Pugh, MD
Presentations
None
Publications
Submitted for review
Additional Grants and Awards
None
Project Status
Ongoing – Currently submitted and under review for publication
Submitted
December 2010
Title of Grant
Locking Plate Fixation of Patella Fractures: A Biomechanical Study
Principal Investigator
Kristine E Banks, MD
Co-Investigator
Milan Sen, MD
OTA 2010 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: June 1, 2010 – May 31, 2011) |
Principal Investigator
Mitchell Bernstein, MD
Co-Investigator
Edward Harvey, MD
Grant Title
The Use of Contrast Media in Detecting Traumatic Knee Arthrotomy
Grant Funded by
Principal Investigator
Paul Chin, MD, PhD
Co-Investigator
Joseph Borrelli, Jr, MD
Grant Title
Effect of BMP-7 on Articular Cartilage Following an Impact Load
Grant Funded by
Principal Investigator
Niloofar Dehghan, MD
Co-Investigator
Kreder Hans, MD, MPH, FRCS(C)
Grant Title
A Pilot Study of a Prospective Randomized Trial Comparing Early Post-Operative Motion and Weight-Bearing to Immobilization After Surgical Fixation of Bimalleolar Ankle Fractures
Grant Funded by
Principal Investigator
E. Stephan Garcia, MD
Co-Investigator
Amr Abdelgawad, MD
Grant Title
Use of Local Free Antibiotic Powder in the Treatment of Osteomyelitis
Grant Funded by
Principal Investigator
Rachel Goldstein, MD, MPH
Co-Investigator
Nirmal Tejwani, MD
Grant Title
Efficacy of Popliteal Block in Post-operative Pain Management for Ankle Fractures. A Prospective Randomized Study
Grant Funded by
Principal Investigator
William Graham, MD
Co-Investigator
Thomas Ellis, MD
Grant Title
Acetabular Fracture after Total Hip Replacement
Grant Funded by
Principal Investigator
Jason Hsu, MD
Co-Investigator
Samir Mehta, MD
Grant Title
Oxygen Partial Pressure Monitoring in Impending Compartment Syndrome Associated with Diaphyseal Tibia Fractures
Grant Funded by
Principal Investigator
Lukas Nystrom, MD
Co-Investigator
Todd McKinley, MD
Grant Title
Accurate Radiographic Assessment of Pelvic Ring Fracture Deformity
Grant Funded by
Principal Investigator
Kevin O'Neill, MD, MS
Co-Investigator
William Obremskey, MD, MPH
Grant Title
Quantitative Axial Micro-CT as a Surrogate for Biomechanics in a Mouse Fracture Model
Grant Funded by
Principal Investigator
Jaron Sullivan, MD
Co-Investigator
J. Lawrence Marsh, MD
Grant Title
Accurate Screw Placement for Calcaneus Fixation
Grant Funded by
Principal Investigator
John Tidwell, MD
Co-Investigator
David Hubbard, MD
Grant Title
The Effects of Melatonin on Fracture Healing in a Traumatic Femur Fracture Model
Grant Funded by
Principal Investigator
Lindley Wall, MD
Co-Investigator
Michael Gardner, MD
Grant Title
Volar Locking Plates for Extra-Articular Distal Radius Fractures: Is Unicortical Fixation Sufficient?
Grant Funded by
Principal Investigator
Akira Yamamoto, MD
Co-Investigator
Amir Matityahu, MD
Grant Title
Comparison of long versus short intramedullary hip nails for fixation of unstable intertrochanteric hip fractures: a cadaveric study
Grant Funded by
2009
Directed Topic Clinical Studies (up to $50,000/year, 3-year funding cycle)
(Proximal Humerus Fractures, Economic Outcomes in Trauma Care, Clinical Trial Re-evaluation of non-operative problems, Effect of non-operative post surgical therapy in trauma) |
Title of Grant
Psychological Factors Predict Disability After Musculoskele Trauma
Principal Investigator
Ana-Maria Vranceanu, PhD
Co-Principal Investigator
David Ring, MD, PhD
Awarded Grant
$80,000 (2-year)
Presentations
ASSH – 2010
Preparing Abstract for OTA 2011
Publications
None
Additional Grants and Awards
None
We are working on a collaboration with University of Amsterdam on a 2 sited CBT
intervention. We are also searching for US agencies to fund our grant.
New Product or Patent
None
Project Status
Ongoing
Title of Grant
Early Psychiatric Intervention after Orthopaedic Trauma A Prospective, Randomized Double-Blinded Placebo Controlled Trial
Principal Investigator
Adam Starr, MD
Co-Principal Investigator
Joseph Borrelli, MD
Awarded Grant
$148,806 (3-year)
Title of Grant
“Development and testing of a postoperative pain outcome tool for orthopaedic trauma surgery"
Principal Investigator
Kristin Archer, PhD
Co-Principal Investigator
William Obremskey, MD, MPH
Amount and Date Funded
$131,100 (3-year)
Presentations
None
Publications
Pain and Satisfaction in Hospitalized Trauma Patients
Development of a Multidimensional postoperative Pain Instrument
(MPPI) in Patients Following Traumatic Injury
Submitted
In preparation
Additional Grants and Awards
None
New Product or Patent
None
Project Status
Ongoing
Title of Grant
The role of Antibiotics in Open Fractures Revisited: Characteristics of Staphylococcus Aureus and Susceptibility Profile
Principal Investigator
Carla Saveli, MD Connie S. Price, MD
Co-Principal Investigator
Steven Morgan, MD
Awarded Grant
$80,000 (2-year)
Presentations
Surgical Infection Society
Submitted
May 2011
Publications
None
Project Status
Ongoing
Clinical Grants (up to $40,000/year, 2 year Grant Cycle) |
Title of Grant
Operative and Non-Operative Scapular Body and Glenoid Neck Fracture Treatment Indications
Principal Investigator
Clifford Jones, MD
Co-Principal Investigator
Debra Sietsema, PhD
Awarded Grant
$80,000 (5-year)
Presentations
None
Publications
None
Additional Awards and Grants
None
New Product or Patent
None
Pending Publications
Abstracts will be submitted for presentations and a paper for publication upon completion of study.
Project Status
Ongoing
Basic Research Grants (up to $25,000, 1 year Grant Cycle) |
Title of Grant
Local Drug Delivery Systems for the Treatment of Infections
Principal Investigator
Michael Bosse, MD
Co-Principal Investigator
John Ellington, MD
Awarded Grant
$24,200
Presentations
None
Publications
None
Additional Grants and Awards
Recently requested and were approved for a no cost extension.
Project Status
Ongoing
Title of Grant
Acute Cartilage Damage Associated with Intraarticular Fractures
Principal Investigator
Yuki Tochigi, MD, PhD
Co-Investigator
Todd McKinley, MD
Amount and Date Funded
$25,000 - January 1, 2009 - December 31, 2009
Presentations
Meetings
- Tochigi Y, Martin JA, Rudert MJ, McCabe D, Goreham-Voss CM, Buckwalter JA, Brown TD. Acute phase pathology of cartilage injury in human ankle intraarticular fractures. 55th Annual Meeting of the Orthopaedic Research Society, February 22–25, 2009, Las Vegas, Nevada. Abstract ID: ORS2009-2661, Poster Presentation #1078, Poster Session 25: Cartilage Impact Models.
- Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. A new insult technique for a large animal survival model of human intra-articular fracture. OARSI World Congress on Osteoarthritis 2009, September 10–13, 2009, Montreal, Quebec, Canada. Abstract Control #589, Poster Presentation.
- Tochigi Y, Martin JA, Lehman A, Vaseenon T, Zhang P, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in human ankle intraarticular fractures. OARSI World Congress on Osteoarthritis 2009, September 10–13, 2009, Montreal, Quebec, Canada. Abstract Control #183, Poster Presentation.
- Tochigi Y, Martin JA, Lehman A, McKinley TO, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in ankle intra-articular fractures. 2009 Orthopaedic Trauma Association Pre-Meeting Courses: Basic Science Focus Form, October 7–8, 2009, San Diego, California. Abstract #: 435, Final Program Paper #: BSFF 11, Podium Presentation.
- Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. Development of a large survival animal model of human intraarticular fracture: A new technique to replicate cell-level cartilage pathology in the porcine hock in vivo. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010, New Orleans, Louisiana. Abstract ID: ORS2010-2172. Paper #:355: Short Talk Session 12 Biology of Fracture Repair.
- Tochigi Y, Buckwalter JA, Zhang P, Vaseenon T, Lehman AD, Martin JA, Brown TD. Distribution and progression of chondrocyte damage in human ankle intraarticular fractures. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010, New Orleans, Louisiana. Abstract ID: ORS2010–2200. Poster #943: Session 25 Cartilage Matrix Degradation.
- Zhang P, Tochigi Y, Sauter EE, Martin JA, Brown TD. Chondrocyte death cascade in fracture-damaged cartilage in a porcine whole-organ model. 56th Annual Meeting of the Orthopaedic Research Society, March 6–9, 2010, New Orleans, Louisiana. Abstract ID: ORS2010-2149. Poster #952: Session 25 Cartilage Matrix Degradation.
Publications
Yes
Name of Publication Month/Year Volume #
- Tochigi Y, Baer TE, Zhang P, Martin JA, Brown TD. A new insult technique for a large animal survival model of human intra-articular fracture. Osteoarthritis Cartilage 2009;17 (Supp 1):S51–52.
- Tochigi Y, Martin JA, Lehman A, Vaseenon T, Zhang P, Buckwalter JA, Brown TD. Acute-phase aggravation of chondrocyte death in human ankle intraarticular fractures. Osteoarthritis Cartilage 2009;17 (Supp 1):S112–113.
Did this research grant lead to the development of a larger grant and additional awards from other sources?
Yes
Additional Grants and Awards
Title of Grant
Prompting Cartilage Stem Cell Activity to Improve Recovery From Joint Fracture
Funding Source
Department of the Army — USAMRAA
Project Dates
09/27/10-09/26/11
Total Project Costs
$143,753
Submitted
September 2009
Title of Grant
A Clinically Realistic Large Animal Model of Intra-Articular Fracture
Funding Source
Department of the Army — USAMRAA
Project Dates
09/15/10–09/14/13
Total Project Costs
$1,348,298
Submitted
November 2009
Did this research grant lead to the development of a patent?
None
Is this project concluded?
No
If the project is not concluded, are additional publications and related grants expected?
Yes
Pending Publications
Tochigi Y, Buckwalter JA, Martin JA, Hillis SL, Zhang P, Vaseenon T, Lehman AD, Brown TD. Distribution and progression of chondrocyte damage in a whole organ model of human intra-articular fracture. J. Bone Joint Surg Am. ( in print)
Project Status
Ongoing
Classification Database and Outcomes Committee Pilot Project |
Title of Grant
Development of Fracture Specific MFA Outcomes Scores - Pilot Project for Planning the
Major Investigation
Principal Investigator
Douglas W. Lundy, MD
Co-Principal Investigator
Julie Agel, MA
Awarded Grant
$6,003
Presentations
None
Publications
None
Additional Awards and Grants
None
New Product or Patent
None
Project Status
Ongoing
rhBMP-2 (up to $65,000/year, 2 - 3 year funding cycle)
**Basic** |
Title of Grant
Combined Use of Recombinant Human Bone Morphogenetic Protein-2 and Low Intensity Pulsed Ultrasound in Orthopedic Traumatology
Principal Investigator
Amarjit Virdi, PhD
Co-Principal Investigator
Walter Virkus, MD
Awarded Grant
$129,709 (2-year)
Project Status
Ongoing. One year, no cost extension granted 01/24/2011
OTA 2009 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: January 1, 2009 – December 31, 2009) |
Title of Grant
Harnessing Collective Intelligence for the Management of Subcapital Hip Fractures
Principal Investigator
Jaimo Ahn, MD, PhD
Co-Investigator
Joseph Bernstein, MD, MS
Amount Funded
$10,000
Presentations
Publications
Additional Grants and Awards
Project Status
Title of Grant
Inflammatory Response to Trauma in the Obese
Principal Investigator
Arun Aneja, MD
Co-Investigator
George Russell, MD
Amount and Date Funded:
$10,000
Presentations
Mississippi Orthopaedic Society - May 2010
Publications
Induced Pulmonary Injury in the Obese Zucker Rat; Orthopaedic Trauma; 11/17/10, doi:10.1111/j.1549-8719.2010.00061.x.
Additional Grants and Awards
Yes
Grant Title
AONA Kathryn Cramer Memorial
Amount Award
$14,800.00
Funding Cycle
06/15/2010-06/14/2011
Grant Title
Mississippi Institute of Minority Health
Amount Awarded
$5,000
Funding Cycle
5/09-5/10
New Product or Patent
None
Pending Publications
Microcirculation Journal - awaiting results/date s
Submitted
March 2010
Project Status
Ongoing
Title of Grant
Measurement of Tissue Oxygenation for Diagnosis of Acute Compartment Syndrome f following Tibia Fracture A Pilot Study
Principal Investigator
Erik Hansen, MD
Amount Funded
$10,000
Co-Investigator
Utku Kandemir, MD
Title of Grant
Osteogenic Cell Viability in Bone Graft Obtained in Reamer Irrigator and Aspirator (RIA) System Versus Iliac Crest Bone Graft
Principal Investigator
Raj Kakarlapudi, MD
Amount Funded
$10,000
Co-Investigator
Brett Crist, MD
Presentations
Mid-America Orthopaedic Association Annual Meeting
Submitted
April 2011
Publications
None
Additional Grants and Awards
AO North America Resident Research Award
Amount Awarded
$5,000.00
Funding Cycle
2008-2009
New Product or Patent
None
Pending Publications
Manuscript expected once larger sample size is completed
Project Status
Ongoing
Title of Grant
The effects of suramin treatment on fracture healing and muscle regeneration in a rodent model
Principal Investigator
Ethan Kellum, MD, MS
Amount Funded
$10,000
Co-Investigator
Michael Tucker, MD/
Title of Grant
Foreign-body Induced Biomembranes in Segmental Bone Defects: Histologic, Immunohistochemical, and Gene Expression Properties in a Rat Model
Principal Investigator
James Starman, MD
Amount Funded
$10,000
Co-Investigator
Michael Bosse, MD
Presentations
None
Publications
None
Additional Grants and Awards
None
New Product or Patent
None
Project Status
Concluded – We are in the process of writing a manuscript. Additional Abstract submissions to The Association of Bone and Joint Surgeons 63rd Annual Meeting and the 2011 Orthopaedic Trauma Association Annual Meeting are pending. We expect a manuscript to be completed in the next two to three months.
Title of Grant
Effect of Mesenchymal Stem Cell-Based Gene Transfer of VEGF and eNOS on Healing of a Segmental Bone Defect
Principal Investigator
Aaron Nauth, MD
Amount Funded
$10,000
Co-Investigator
Emil Schemitsch, MD FRCSC
Presentations
Orthopaedic Trauma Association Annual Meeting – October 2009
Orthopaedic Research Society Annual Meeting – March 2010
American Academy or Orthopaedic Surgery – March 2010
Publications
Journal of Orthopaedic Trauma; March 2010; 24:S17-24
Journal of Orthopaedic Trauma; September 2010; 24(9):547-53
Additional Grants and Awards
PSIF Resident Grant
Amount Awarded
$25,000.00
Funding Cycle
2009-2010
Additional Grants and Awards
Cihr Banting and Best Master’s Award
Amount Awarded
$18,500.00
Funding Cycle
2009-2010
New Product or Patent
None
Project Status
Concluded
Title of Grant
Vacuum assisted closure of acetabular fracture incisional wounds in the obese.
Principal Investigator
Matthew Futvoye, MD
Amount Funded
$10,000
Co-Investigator
George Russell, MD
Title of Grant
Sterility of Intraoperative Irrigation
Principal Investigator
Thomas Jones, MD
Amount Funded
$10,000
Co-Investigator
Laura Prokuski, MD
Title of Grant
Characterization of the Interface between Neocartilage Produced by Nonarticular Chondrocytes and the Subchondral Bone
Principal Investigator
Tamara Pylawka, MD
Amount Funded
$10,000
Co-Investigator
Spence Reid, MD
OTA 2009 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: June 1, 2009 – May 31, 2010) |
Title of Grant
Retropatellar Technique for Intramedullary Nailing of Tibia Fractures: A Prospective Evaluation
Principal Investigator
Jonathon G. Eastman, MD
Co-Investigator
Brad J. Yoo, MD
Grant Funded by
AO North America/OTA
Presentations
None
Publications
None
Additional Grants and Awards
None
New Product or Patent
None
Project Status
Ongoing
Title of Grant
Does Plugging unused screw holes increase the strength of locked compression plates in comminuted supracondylar femur fractures?
Principal Investigator
Reza Firoozabadi, MD
Co-Investigator
Utku Kandemir, MD
Grant Funded by
AO North America/OTA
Presentations
Submitting to OTA
Submitted
February 2011
Pending Publications
Submitting to JBJS
Submitted
March 2011
Additional Grants and Awards
None
New Product or Patent
None
Project Status
Ongoing
Title of Grant
Immediate Weight Bearing of Comminuted Distal Femur Fractures Using Locked Plate Fixation: A Biomechanical Analysis
Principal Investigator
Jaymes Granata, MD
Co-Investigator
Thomas J.Ellis, MD
Grant Funded by
Foundation for Orthopaedic Trauma /OTA
Title of Grant
The Stability of the Postero-Medial Tibial Plateau Fracture Fragment Depends on Fragment Size, Knee Flexion Angle, and Applied Load
Principal Investigator
Igor Immerman, MD
Co-Investigator
Kenneth A. Egol, MD
Grant Funded by
Foundation for Orthopaedic Trauma /OTA
Presentations
None
Pending Publications
Expected at project completion
Additional Grants and Awards
None
New Product or Patent
None
Project Status
Ongoing
Title of Grant
The effect of screw size on fatigue strength of fixation with statically locked Intramedullary Nails in Comminuted Femoral Shaft Fractures
Principal Investigator
Michael P. Kelly, MD
Co-Investigator
Utku Kandemir, MD
Grant Funded by
Foundation for Orthopaedic Trauma /OTA
Title of Grant
The Effect of Repetitive Insertion On The Pullout Strength of Screws
Principal Investigator
Jeremiah Jonathan Maddox, MD
Co-Investigator
James P. Stannard, MD
Grant Funded by
OTA
Title of Grant
The effect of statin lipophilicity on bone fracture healing
Principal Investigator
Jason C. Phillips, MD
Co-Investigator
James S. Raphael, MD
Grant Funded by
Title of Grant
Preliminary study to identify osteoblastic cells in the peripheral circulation in mice.
Principal Investigator
Brian A. Silvia, MD,PhD
Co-Investigator
Thomas Goss, MD
Grant Funded by
OTA
Title of Grant
Quantitative Assessment of Osteogenic Genes and Proteins from Alternate Bone-
Graft Harvesting Sites.
Principal Investigator
Richelle Carrie Takemoto, MD
Co-Investigator
Kenneth A. Egol, MD
Grant Funded by
OTA
Title of Grant
Osteotropic Peptides: Therapy for Post-traumatic Osteonecrosis of the Femoral Head
Principal Investigator
Sarah R. Zawodny, MD
Co-Investigator
Quanjun Cui, MD
Grant Funded by
OTA
2008
OTA 2008 GRANT AWARDS
(Grant Cycle: January 1, 2008 – December 31, 2008) |
Clinical Grants (up to $40,000/year, 2 year grant cycle) |
Title of Grant
“A Multicenter Randomized Clinical Trial of Non-operative versus Operative Treatment of
High-grade, Acute Acromio-clavicular Joint Dislocation”
Grant Funded by
OTA/Synthes
Principal Investigator
Michael McKee, MD, FRCS(C)
Co-Investigator
Guy Pierre, MD, FRCS(C)
Amount and Date Funded:
$50,000 (3-year grant cycle)
Presentations
None
Publications
None
Additional Grants and Awards
OTC Grant
Amount Awarded
$50,000 ($25,000/year)
Funding Cycle
2008 (2 year cycle)
Project Status
Ongoing
We have reached our sample size and enrollment has concluded. We are quite satisfied with the quality of data collected thus far, however, data collection is ongoing. We expect to have an abstract prepared to be submitted in 2012, once we obtain the 2 year follow-up for all enrolled subjects.
Title of Grant
“Cerebrospinal Fluid Cytokines as Biomarkers for Delirium Following Hip Fracture Repair
in Elders”
Grant Funded by
OTA/Stryker Orthopaedics
Principal Investigator
Simon Mears, MD, PhD
Co-Investigator
Ronald Byank, MD
Amount and Date Funded
$39,620 (year 1: $19,810 – year 2: $19,810)
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
Ongoing
Title of Grant
“Intramedullary Nails versus Plate Fixation Re-Evaluation Study in Proximal Tibia Fractures: A Multicenter Rando mized Trial Comparing IM Nails and Plate Fixation (IMPRESS)”
Grant Funded by
OTA/Orthofix
Principal Investigator
Paul Tornetta, MD
Amount Funded
$80,000
Co-Investigator
Andrew Schmidt, MD (year 1: $39,500 – year 2: $40,500)
Presentations
None
Publications
None
Additional Awards and Grants
None
New Project or Patent
None
Project Status
Ongoing
Title of Grant
“A Study of Locked Plates versus Intramedullary Nails in Distal Femur Fractures:
A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation (SOLVED)”
Grant Funded by
OTA/AO North America & Smith and Nephew
Principal Investigator
Paul Tornetta, MD
Amount Funded
$80,000
Co-Investigator
William Ricci, MD (year 1: $39,500 – year 2: $40,500)
Presentations
None
Publications
None
Additional Grants and Awards
None
New Product or Patent
None
Project Status
Ongoing
rhBMP-2 ($65,000/year, 2 - 3 year funding cycle) |
Title of Grant
“RhBMP2 vs. Autograft for Critical Size Tibial Defects: A multi-center randomized trial”
Grant Funded by
OTA/Medtronic
Principal Investigator
Lisa Cannada, MD
Co-Investigator
Paul Tornetta, MD (2-year grant cycle)
Amount and Date Funded
$63,494
Presentations
None
Publications
None
Additional Grants and Awards
Yes
Grant Title
RhBMP2 vs. Autograft for critical Size Tibial Defects: A multi-center randomized trail funded by the Department of Defense as part of the Major Extremity Trauma Research Consortiu.
Amount Funded
$1.2 million
Grant Cycle
2010-2013
New Product or Patent
None
Project Status
Ongoing
Basic Research Grants (up to $25,000, 1 year grant cycle) |
Title of Grant
“Objective Assessment of Fracture-Associated Soft Tissue Injury Using CT-Based Texture Analysis”
Grant Funded by
OTA/AO North America
Principal Investigator
Donald Anderson, PhD
Co-Investigator
J. Lawrence Marsh, MD
Amount and Date Funded
$25,000
Presentations
54th Annual Meeting of the Orthopaedic Research Society - San Francisco, CA - March 2-5, 2008
75th Annual Meeting of the AAOS - San Francisco, CA - March 5-9, 2009
OARS! World Congress on Osteoarthritis 2008 - Rome, Italy - September 2008
55th Annual Meeting of the Orthopaedic Research Society - Las Vegas, NV - February 22-25, 2009
Publications
Osteoarthritis and Cartilage - September 2008; 16(Supp 4)
Additional Grants and Awards
Pending grant - Army/PRORP Hypothesis Development Award/Sept. 15, 2009 submitted.
Project Status
Concluded
Title of Grant
“Trans-sacral/Alar Screw Fixation for Comminuted Transforaminal Sacral Fractures”
Grant Funded by
OTA/Biomet Trauma
Principal Investigator
Brett Crist, MD
Amount Funded
$25,000
Co-Investigator
Gregory Della Rocca, MD, PhD
Presentations
OTA Annual Meeting – Basic Science Forum – October 2010
AO North America – 2010 challenges in Fracture Care across Disciplines – November 2010
Orthopaedic Research Society – Annual Meeting 0 January 2011
AAOS Annual Meeting – February 2011
Publications
None
Additional Grants and Awards
None
New Product or Patent
None
Pending Publications
Manuscript submitted as part of OTA Basic Science Forum for Journal of Orthopaedic Trauma – September 2010
Project Status
Ongoing
Title of Grant
“Real-Time In Vivo Profiling of Vascular Endothelial Growth Factor Receptor 2 Expression
During Bone Healing in Living Mice”
Grant Funded by
OTA/Biomet Trauma
Principal Investigator
Philipp Mayer-Kuckuk, PhD
Amount Funded
$25,000
Co-Investigator
Joseph Lane, MD
Title of Grant
“Efficacy and Safety of Covalently Bonded Silver External Fixation Pins”
Grant Funded by
OTA/Stryker Orthopaedics
Principal Investigator
Greg Merrell, MD
Amount Funded
$25,000
Co-Investigator
Michael Medvecky, MD
Presentations
None
Publications
None
Additional Grants and Awards
Canadian IRAP Grant
Additional Grant Amount
$230,000
Funding Cycle
2010
New Product or patent
Antibiotic coated orthopaedic implants are being developed but have yet to reach commercial production.
Pending Publications
A manuscript is in preparation
Project Status
Ongoing
OTA 2008 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: January 1, 2008 – December 31, 2008) |
Title of Grant
Antibiotic Prophylaxis in Orthopaedic Traumatology: A Prospective, Randomized Trial of
Duration of Administration
Grant Funded by
OTA/FOT
Principal Investigator
David Greenberg, MD
Co-Investigator
Brett Crist, MD
Amount Funded
$10,000
Date Funded
January 2008
Presentations
None
Additional Grants and Awards
None
Project Status
2008-Extension approved.
2009 - Data collection is ongoing. Anticipation of 1-2 years prior to completion.
Title of Grant
Analysis of Long Bong Fracture Nonunion by an expression profile of the Matrix Metalloproteinases and ADAMTS enzyme families: a prospective study
Principal Investigator
Marc Fajardo, MD
Amount Funded
$10,000
Co-Investigator
Kenneth Egol, MD
Grant Funded by
OTA/FOT
Presentations
Medical Society of New York Annual Meeting – 2008
ATA Annual Meeting – 2008
AAOS Annual Meeting – 2009
AREF Annual Research Symposium – NY – 2008
ASBMR Annual Meeting – 2008
Publications
Fajardo M, Liu CJ, Ilalov, K, Egol, K; Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are el3vated in hypertrophic fracture nonunion tissue. Journal of Orthopaedic Trauma; 2010 Sept 24(9):557-63
Additional Grants and Awards
None
New Product or Patent
None
Project Status
Concluded
Title of Grant
Axial CT Evaluation of the Distal Tibiofibular Syndesmosis
Grant Funded by
OTA/FOTA
Principal Investigator
Gregory Dikos, M.D
Co-Investigator
Timothy Weber, M.D
Amount and Date Funded
$10,000 January 1, 2008 - December 31, 2008
Presentations
32nd Annual Garceau-Wray Lectureship June 2008 - Indiana University School of Medicine
25th Annual OTA Meeting Poster - October 2009 - San Diego, California
Publications
None
Additional Grants and Awards
Methodist Research Institute Grant - $10,000 Funding Cycle: 1/1/2008 - 12/31/2008
Indiana University Foundation Grant - $2,000 Funding Cycle: 1/1/2008 - 12/31/2008
New Product or Patent
None
Pending Publications
JBJS.
Submitted
June 2010. Awaiting final decision.
Project Status
Concluded
Title of Grant
Does Leptin Modulate Fracture Healing After Traumatic Brain Injury?
Principal Investigator
Safdar Khan, MD
Amount Funded
$10,000
Co-Investigator
Mark Lee, MD
Grant Funded by
OTA/FOT
Title of Grant
Effects of FGF-2 and BMP-7 on articular injuries in rabbits
Principal Investigator
Alexis Dang, MD
Amount Funded
$10,000
Co-Investigator
Theodore Miclau, MD
Grant Funded by
OTA/FOT
Title of Grant
”Ultrasound for the Use of Predicting Union After Tibia Fractures Treated with Reamed
Intramedullary Interlocked Nails
Grant Funded by
OTA/Medtronic
Principal Investigator
Adam Rana, MD
Co-Investigator
Paul Tornetta, MD
Amount and Date Funded
$10,000 January 1, 2008 - December 31, 2008
Presentations
OTA Annual Meeting, 25th Anniversary Meeting, San Diego - Oct. 8-10, 2009
OTA Annual Meeting – November 2010
Publications
None
Additional Grants and Awards
None
New Products or Patents
None
Pending Publications
Journal of Orthopaedic Trauma
Submitted
February 1, 2011
Project Status
Concluded
Title of Grant
The effect of nitric oxide on intramedullary vascularity and fracture healing
Principal Investigator
James Meeker, M.D
Amount Funded
$10,000
Co-Investigator
Laurence Dahners, M.D.
Grant Funded by
OTA/Medtronic
Title of Grant
The Effects of Hypothermia and Mediators on Skeletal Muscle Function Following
Ischemia-Reperfusion Injury
Principal Investigator
Daniel Stahl, MD
Co-Investigator
Robert Probe, MD
Grant Funded by
OTA/Medtronic
Amount and Date Funded:
$10,000 January 1, 2008 - December 31, 2008
Presentations
OTA Annual Meeting, October 2010
Publications
None
Additional Grants and Awards
None
New Product or Patent
None
Pending Publications
Submitted to Journal of Orthopaedic Trauma, January 2011
Project Status
Concluded, 2009
Title of Grant
Effect of Timing of Indomethacin Administration on Cell Damage due to Elevated
Compartment Pressure: An Intravital Videomicroscopy
Study in Rats
Principal Investigator
Ajay Manjoo, MD
Amount Funded
$10,000
Co-Investigator
David Sanders, MD
Grant Funded by
OTA/Medtronic
Title of Grant
The Mechanism for Chondrocyte Apoptosis Following Mechanical Injury
Principal Investigator
Eric Eisner, MD
Amount Funded
$10,000
Co-Investigator
Joseph Borrelli, MD
Grant Funded by
OTA/AO North America
Title of Grant
The Use of Bone Marrow-Derived Mesenchymal Stem Cells in the Prevention and Treatment of a Rat Atropic Nonunion Model
Principal Investigator
Susan Tseng, MD
Amount Funded
$10,000
Co-Investigator
Mark Lee, MD
Grant Funded by
OTA/AO North America
Title of Grant
Medial vs. Anterolateral Plating of Extraarticular Distal Tibial Fractures (AO/OTA 43A):
A Biomechanical Analysis
Principal Investigator
Aaron Chamberlain, MD
Amount Funded
$10,000
Co-Investigator
Robert Dunbar, MD
Grant Funded by
OTA/Smith & Nephew Orthopaedics
Title of Grant
Comparison of short and long Cephalomedullary nail in treatment of unstable
intertrochanteric hip fractures-Biomechanical study
Principal Investigator
Mark Stouffer, MD
Amount Funded
$10,000
Co-Investigator
Michael Prayson, MD
Grant Funded by
OTA/Smith & Nephew Orthopaedics
2008
OTA 2008 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: June 1, 2008 – May 31, 2009) |
Title of Grant
Effect of Tibial Plateau Fracture on Synovial Fluid Lubrication Function and Constituents
Principal Investigator
Brooke Ballard, M.D.
Amount Funded
$10,000
Co-Investigator
Alexandra Schwartz, M.D.
Grant Funded by
OTA/AO North America
Presentations
Ruth Jackson Research Resident Presentation, February 2009
OREF Research Presentation, May 2008
Publications
None
Additional Grants and Awards
NIH
New Product or Patent
None
Pending Publications
Effect of Tibial Plateau Fracture on Lubrication Function and Composition of Synovial
Fluid.
Submitted
December 31, 2010
Project Status
Ongoing
Title of Grant
Can the Use of Polyaxial Distal Radius Locking Plates Compensate for Suboptimal Plate Position?
Principal Investigator
James Halloran, MD Melissa Collins, MD
Amount Funded
$10,000
Co-Investigator
Edward Harvey, MSc, MD, FRCSC
Grant Funded by
OTA/AO North America
Presentations
McGill Orthopaedic Resident Research Day
Submitted
April 2009
Publications
None
Additional Grants
None
New Product or Patent
None
Pending Publications
Will be submitted when completed
Project Status
Ongoing – Further material has been obtained at our expense to completed project.
Title of Grant
Ulnar Neck Fractures: A Biomechanical Study
Grant Funded by
OTA/AO North America
Principal Investigator
Jerod Hines, MD
Co-Investigator
Max Talbot, MD, FRCS
Amount and Date Funded
$10,000
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
Ongoing. 2009 update: Awaiting the hardware for testing.
Title of Grant
Acceleration of Fracture Healing by Novel Polypeptides
Principal Investigator
Kyle Kokko, MD, PhD
Amount Funded
$10,000
Co-Investigator
Langdon Hartsock, MD
Grant Funded by
OTA/AO North America
Title of Grant
A Prospective Evaluation of Brain Oxygenation and Neurologic Outcomes After Intramedullary Nailing in Patients with Long Bone Fractures and Head Injury.
Principal Investigator
J. Stuart Melvin, MD
Amount Funded
$10,000
Co-Investigator
Samir Mehta, MD
Grant Funded by
OTA/AO North America
Presentations
None
Publications
None
Additional Grants
None
New Product or Patent
None
Project Status
Ongoing
Title of Grant
Role of PAR-2 in Fracture Healing
Principal Investigator
Jonathan Schoenecker, MD, PhD
Amount Funded
$10,000
Co-Investigator
William Obremskey, MD, MPH
Grant Funded by
OTA/AO North America
Title of Grant
Efficacy and Dose Evaluation of TPO in Healing Critical-Sized Femoral Defects
Grant Funded by
OTA/AO North America
Principal Investigator
Jonathan Wilhite, MD
Co-Investigator
Jeffrey Anglen, MD
Amount and Date Funded
$10,000
Presentations
Indiana University School of Medicine, Department of Orthopaedic Surgery Garceau-Wray Lectureship – June 2010
Indiana Orthopaedic Society (scheduled) – May 2011
Publications
None
Additional Grants and Awards
NIH R21 or R01 anticipated (Date submitted 10/2010)
Pending Grants
Critical-sized defect regeneration using thrombopoietin-loaded scaffolds.
Anticipated resubmission date: 03/16/2011.
Developing load-bearing biodegradable scaffold for mouse segmental defect models. Anticipated submission date: 02/25/2011.
New Product or Patent
US provisional patent on the invention June 3, 2010 (IURTC Tech No. 10099). “Bone Healing by a novel compound.”
Project Status
Completed
OTA 2007 GRANT AWARDS
(Grant Cycle: January 1, 2007 – December 31, 2007) |
Clinical Grant Applications (up to $40,000/year, 2 year grant cycle) |
Title of Grant
“Dynamic Hip Screw vs. Trochanteric Fixation Nail in the Treatment of Intertrochanteric
Hip Fractures”
Grant Funded by
OTA/DePuy, a Johnson & Johnson Company
Principal Investigator
Rudolph Reindl, MD
Co-Investigator
Edward J. Harvey, MD
Amount and Date Funded
$80,000 (2-year grant) ($40,000 - 2007, $40,000 - 2008)
Presentations
Canadian Orthopaedic Association Meeting, Quebec City - June 2008
(Results of pilot study).
Publications
None
Additional Grants and Awards
2007 Synthes Research Grant
Amount Awarded - $20,000.00
2008 Synthes Research Grant
Amount Awarded - $20,000.00
Project Status
2008-Ongoing
Title of Grant
“A Prospective Randomized Trial Comparing Open Reduction and Internal Fixation, Non-Spanning External Fixation, and Closed Reduction with Percutaneous Fixation in Displaced Distal Radius Fractures with Joint Congruity”
Grant Funded by
OTA/Zimmer
Principal Investigator
Gregory K. Berry, MD
Co-Investigator
Hans J. Kreder, MD
Amount and Date Funded:
$80,000 (2-year grant) ($40,000 - 2007, $40,000 - 2008)
Presentations
Boston OTA/COTS (Update) Oct. 2007
Quebec OTA/COTS (Update) June 2008
Quebec OCCG (Update) June 2008
Canadian Orthopaedic Trauma Society – Edmonton, AB June 2010
Canadian Orthopaedic Trauma Society – Baltimore, MD October 2010
Publications
None
Additional Grants and Awards
None
New Product or Patent
None
Project Status
2008-Ongoing and is now multi-study. Six out of eight centers actively recruiting.
Extension requested. Completion of patient enrollment in 2010, one year later than
foreseen.
Title of Grant
“Outcomes of Femur Fractures: RIA versus Standard Reaming”
Grant Funded by
OTA/Biomet Trauma
Principal Investigator
Kyle J. Jeray, MD
Co-Investigator
J. Scott Broderick, MD
Amount and Date Funded:
$80,000 $40,000 - 2007, $40,000 – 2008 (2 year Grant)
Presentations
None at this time
Publications
None at this time
Additional Grants and Awards
Synthes supply grant. In process of obtaining additional funding to hire Clinical Research Assistant.
Project Status
2008 - Ongoing, open and actively enrolling patients. Currently 45 patients enrolled. This grant is currently funding a multi-center study entitled “Standard Reaming versus Reaming/Irrigating/Aspirating for Intramedullary Nailing of Femoral Shaft Fractures (S.T.A.F.F.).
Directed Topic Clinical Study: (up to $50,000/year, 3 year funding cycle) |
Title of Grant
“Timing of Orthopaedic Surgery in the Multiply-injured Patient: Development of a
Protocol for Early Appropriate Care”
Grant Funded by
OTA/Smith & Nephew/Medtronic
Principal Investigator
Heather A. Vallier, MD
Amount Funded
$150,000 (3-year grant)
Co-Investigator
John Howard Wilber, MD
Amount and Date Funded
$150,000 – 3 year grant $50,000/yr 2007-2009
Presentations
OTA Annual Meeting, October 2008
AAOS Annual Meeting, February 2009
OTA Annual Meeting – October 2010
OTA Annual Meeting – October 2010
OTA Annual Meeting (Poster) – October 2010
Publications
Name of Publication Month/Year Volume #
- Vallier HA, Cureton BA, Eckstein C, Oldenburg FP, Wilber JH. Early definitive stabilization of unstable pelvis and acetabulum fractures reduces morbidity, Journal of Trauma. 69:677-684, 2010
- Nahm N, Como JJ, Wilber JH, Vallier HA. Early appropriate care: definitive stabilization of femoral fractures within 24 hours is safe in most multiply-injured patients, Journal of Trauma, in press, 2010.
- Vallier HA, Super DM, Moore TA, Wilber JH. Do patients with multiple system injury benefit from early fixation of unstable axial fractures? The effects of timing of surgery on initial hospital course. Journal of Orthopaedic Trauma, submitted for publication, 2010.
- Multiple other publications are anticipated.
Additional Grants and Awards
Submitted, unfunded:
- Timing of Orthopaedic Surgery in the Multiply-Injured Patient: A Prospective Protocol for Early Appropriate Care of unstable fractures of the pelvis and femur. OREF 2008
- Timing of Orthopaedic Surgery in the Multiply-Injured Patient: A Prospective Protocol for Early Appropriate Care of unstable fractures of the pelvis and femur. NIH 2009
- Timing of Orthopaedic Surgery in the Multiply-Injured Patient: A Prospective Protocol for Early Appropriate Care of unstable fractures of the pelvis and femur. OREF 2010
Submitted, pending:
- Timing of Orthopaedic Surgery in the Multiply-Injured Patient: A Prospective Protocol for Early Appropriate Care of unstable fractures of the pelvis and femur. NIH 2011
New Product or Patent
None
Project Status
2008-Ongoing
Basic Research Grants (up to $25,000, 1 year grant cycle) |
Title of Grant
“Can we eliminate the need for autologous bone graft harvest for fracture management?
The use of multipotential adipose derived stromal cells in an activated matrix
for in vivo osteogenesis”
Grant Funded by
OTA/Synthes, USA
Principal Investigator
Francis H. Shen, MD
Co-Investigator
Shepard R. Hurwitz, MD
Amount and Date Funded:
$25,000 January 2007
Presentations
International Society for the Study of the Lumbar Spine, June 2007
Sixth Combined Meeting of the Orthopaedic Research Society, October 2007
Publications
2008- Pending Publication, A Novel Reproducible Animal Model Simulation Vertebral Body Defect Repair
Additional Grants and Awards
National Osteoporosis Foundation- $50,000, July 2007-June 2008
Project Status
2008-Ongoing
Title of Grant
“Effect of Delayed Surgery on Infection Rate of Open Fractures in a Rabbit Model”
Grant Funded by
OTA/Stryker Orthopaedics
Principal Investigator
Langdon A. Hartsock, MD
Amount Funded
$25,000
Co-Investigator
Yuehuei An
Amount and Date Funded
$25,0000 January 2007
Presentations
Southern Orthopaedic Association – February 2008
South Carolina Orthopaedic Association – July 2008
MUSC Orthopaedic Siegling Society Research Day - April 2008
Publications
Pending – Journal of Orthopaedic Trauma (plans to submit)
Additional Grants and Awards
NIH ROI (not submitted yet)
Project Status
2008 – Project complete. Plans to submit future grant application for additional
research.
Title of Grant
“Effects of rhBMP-7 on Fracture Healing in an Ischemic Environment”
Grant Funded by
OTA/AO North America
Principal Investigator
Chuanyong Lu, MD
Co-Investigator
Theodore Miclau, III MD
Amount and Date Funded:
$25,000 January 2007
Presentations
ORS 54th Annual Meeting, March 2008
OTA Annual Meeting, October 2008
ORS 55th Annual Meeting, February 2009
OTA Annual Meeting, October 2009 (other work supported by the grant)
ORS 56th Annual Meeting, March 2010 (other work supported by the grant)
OTA Annual Meeting, October 2010 (other work supported by the grant)
Publications
Journal of Orthopaedic Research; May 2010; 28(5)
Journal of Orthopaedic Trauma; 2011; Invited paper
Additional Grants and Awards
None
New Product or Patent
None
Project Status
Concluded
Title of Grant
“Segmental Defect Regeneration Using Biodegradable Load-Bearing BMP-2
Carriers in a Canine Model”
Grant Funded by
OTA/Medtronic
Principal Investigator
Rena L. Stewart, MD
Co-Investigator
Tien-Min Chu
Amount and Date Funded:
$25,000 January 2007
Presentations
Orthopaedic Research Society Meeting- March 2008
Combined AOA/COA Meeting- June 2008
OTA Annual Meeting- October 2008
Publications
Will be submitted fall 2008 for publication to the Journal of Trauma
Additional Grants and Awards
OREF/Zimmer Career Development Grant- $50,000 (2008-2009)
Project Status
2008- Project Completed
OTA 2007 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: June 1, 2007 – May 31, 2008) |
Title of Grant
“The Role of Sensory Nerve Function and Fracture Healing”
Grant Funded by
OTA
Principal Investigator
Peter Apel, MD
Co-Investigator
Robert Teasdall, MD
Amount and Date Funded:
$10,000 June 2007
Presentations
None
Additional Grants and Awards
None
Project Status
Concluded
Title of Grant
“The Use of Osteogenic BMPs to Augment Healing of Critical Sized Femoral Defects in a
Rat Model”
Grant Funded by
OTA
Principal Investigator
Matthew Beal, MD
Co-Investigator
Michael Stover, MD
Amount and Date Funded:
$10,000 June 2007
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
2008-Ongoing/Extension approved.
Title of Grant
“Cytokine liberation from secondary surgery in the setting of the second hit syndrome”
Grant Funded by
OTA
Principal Investigator
Reed Estes, MD
Co-Investigator
David Volgas, MD
Amount and Date Funded:
$10,000 June 2007
Presentations
None
Publications
Pending submission to JOT
Additional Grants and Awards
None
Project Status
2008- Ongoing/Extension approved.
2009 - Completed
Title of Grant
“Correlation of Health Outcome Measure Scores in Foot and Ankle Trauma”
Grant Funded by
OTA
Principal Investigator
Christina Goldstein, MD
Co-Investigator
Bradley Petrisor, FRCSC
Amount and Date Funded
$10,000 June 1, 2007
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
2008-Extension approved. Manuscript currently in preparation, not yet submitted.
Title of Grant
“Relative Effect of Cephalomedullary Nails Versus Sliding Hip Screw in the Treatment of Peri-trochanteric Hip Fractures on Mortality and Re-operation in a Community-Based Clinical Setting”
Grant Funded by
OTA
Principal Investigator
Saam Morshed, MD, MPH
Co-Investigator
Theodore Miclau, MD
Amount and Date Funded:
$10,000 June 1, 2007
Presentations
Publications
Additional Grants and Awards
Project Status
2008-Extension approved. No update report received
Title of Grant
“Time of Exposure to C-arm Drape Contamination”
Grant Funded by
OTA
Principal Investigator
Paul Peters, MD
Co-Investigator
Michael Prayson, MD
Amount and Date Funded:
$10,000 June 1, 2007
Presentations
American Academy of Orthopaedic Surgeons (Poster), March 2008
Mid-America Orthopaedic Association (Podium), April 2008
OTA Annual Meeting Poster, October 2008
AAOS Podium Presentation, 2008/2009 because it was nominated for being one of the top resident papers at MAOA meeting in April, 2008
Publications
None
Additional Grants and Awards
None
Pending Publications
Previously submited paper for publication in the JOT and the JBJS
Currently submitted to Journal of Orthopaedics
Project Status
Concluded
Grant Title
“Operative vs. Non-operative Treatment of Ligamentous SER-4 Ankle Fractures: A
Prospective, Randomized Study
Grant Funded by
OTA
Principal Investigator
Nelson Saldua, MD
Co-Investigator
Michael Mazurek, MD
Amount and Date Funded
$10,000 June 1, 2007
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
2008 - Ongoing
Title of Grant
“Biomechanical Analysis of a New Locked Plating System for the Proximal Humerus”
Grant Funded by
OTA
Principal Investigator
Ross Schumer, MD
Co-Investigator
Michael Prayson, MD
Amount and Date Funded
$10,000 June 1, 2007
Presentations
Military meeting, Las Vegas, December 2008
AAOS Specialty Day, Las Vegas February 2009
Mid America meeting, April 2009
Ohio Orthopaedic Society May 2009
Publications
Journal of Shoulder & Elbow Surgery; June 2010; 19 Issue 4
Additional Grants and Awards
None
New Product or Patent
None
Project Status
2008 – Completed.
Title of Grant
“The Effect of Donor Age on the Healing Potential of (h)BMP-2-expressing, Adipose-Derived Multi-potential Progenitor Cells in the Young-Adult Rat Segmental Femur Defect Model”|
Grant Funded by
OTA
Principal Investigator
Patrick Whitlock, MD, PhD
Co-Investigator
Lawrence X. Webb, MD
Amount and Date Funded:
$10,000 June 1, 2007
Presentations
None
Publications
None
Abstract Submissions
1. Abstract OTA 2010 Annual Meeting, Baltimore
2. Abstract 2010 Challenges in Fracture Care Across Disciplines, Phoenix, AZ
Additional Grants and Awards
None (Pending grants - AO North America)
Project Status
2008 – Project ongoing. Grant extension approved.
2010 - Project ongoing.
Title of Grant
“The Effect of Sacral Fracture Malreduction on the Strength of Iliosacral Screw Fixation
for Transforaminal Sacral Fractures
Grant Funded by
OTA
Principal Investigator
Jason Young, MD
Co-Investigator
Michael Stover, MD
Amount and Date Funded
$10,000 January 2007
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
2008- Research extended one year.
OTA 2007 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: January 1, 2007 – December 31, 2007) |
Title of Grant
“Gait Analysis after Retrograde and Antegrade Intramedullary Nail Fixation of
Femoral Shaft Fractures”
Grant Funded by
OTA/Foundation for Orthopaedic Trauma
Principal Investigator
Sara Strebe, MD
Co-Investigator
Lisa Cannada, MD
Amount and Date Funded:
$10,000 January 2007
Presentations
In progress
Publications
Expecting/pending publications
Additional Grants and Awards
None
Project Status
2008 - Ongoing
2009 – Ongoing, still recruiting patients.
Title of Grant
“Utilizing Nanospheres to Transport Antibiotics Across the Cell Membrane to Kill
Intracellular Staphylococcus Aureus”
Grant Funded by
OTA/ Foundation for Orthopaedic Trauma
Principal Investigator
John Ellington, MD, MS
Amount Funded
$10,000
Co-Investigator
Michael Bosse, MD
Amount and Date Funded
$10,000 January 2007
Presentations
North Carolina Nano Biotechnology Research Award, July 2007
Publications
Res. Soc. Symp. Proc. Mater, Vol. 1019, 2007
Additional Grants and Awards
Yes - 3 pending: 1. Aircast Foundation (98k), NCBC (258k),
Dept of Defense (2.5 million)
Project Status
2008 – Project Concluded
Title of Grant
“Blinding of Outcome Assessors in Clinical Trials of Orthopaedic Trauma”
Grant Funded by
OTA/ Foundation for Orthopaedic Trauma
Principal Investigator
Paul Karanicolas, MD
Amount Funded
$10,000
Co-Investigator
Mohit Bhandari, MD, MSc
Amount and Date Funded
$10,000 January 2007
Presentations
— Inter-observer reliability of classification systems to rate the quality of femoral neck fracture reduction. Orthopaedic Trauma Association (OTA) Annual Meeting. Denver, USA. Oct. 15-18, 2008.
— Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. Orthopaedic Trauma Association (OTA) Annual Meeting. Denver, USA. Oct. 15-18, 2008.
— Blinding of Outcomes in Trials of Orthopaedic Trauma: An Opportunity to Enhance the Validity of Clinical Trials. International Society for Fracture Repair. July 2008.
— A Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. International Society for Fracture Repair. July, 2008.
— Inter-observer reliability of classification systems to rate the quality of femoral neck fracture reduction. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008.
— Blinding of Outcomes in Trials of Orthopaedic Trauma: An Opportunity to Enhance the Validity of Clinical Trials. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008.
— A Creative Approach to Blinding of Outcomes: The Blinding Of Femoral Fixation (BOFF) Study. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) Congress. Nice, France. May 29-June 1, 2008 (Poster Award).
Publications
The Journal of Orthopaedic Trauma 23(6):408-12, July 2009
The Journal of Clinical Epidemiology 62(2):214-223, Feb 2009
The Journal of Bone and Joint Surgery - American volume. 90(5):1026-33, May 2008.
Additional Grants and Awards
None
Project Status
2008 – Financial Report Received
2009 - Concluded
Title of Grant
“The Pathophysiology of Compartment Syndrome: Intracompartmental Pressure, Skeletal Muscle Viability and Microcirculatory Changes”
Grant Funded by
OTA/ Foundation for Orthopaedic Trauma
Principal Investigator
Abdel Rahman Lawendy, MD
Amount Funded
$10,000
Co-Investigator
David Sanders, MD
Amount and Date Funded:
$10,000 January 2007
Presentations
Publications
Additional Grants and Awards
Project Status
2008 – No report received.
Title of Grant
“The Effect of Obesity on Outcomes Among Trauma Patients with Lower Extremity
Orthopaedic Injuries”
Grant Funded by
OTA/ Foundation for Orthopaedic Trauma
Principal Investigator
Rajshri Maheshwari, M.D.
Amount Funded
$10,000
Co-Investigator
Sean Nork, M.D.
Amount and Date Funded
$10,000 January 1, 2007
Presentations
AAOS 75th Annual Meeting, San Francisco, CA, March 2008
Ruth Jackson Orthopaedic Society Biennial Meeting, October 2007
North Pacific Orthopaedic Society 82nd Annual Meeting, September 2007
University of Washington Resident Research Days, June 2007
Publications
Pending – Journal of Orthopaedic Trauma – Revisions submitted July 2008
Additional Grants and Awards
OREF/Depuy Orthopaedic Resident Research Grant $5,000 (1 year)
Frank B. Smith Memorial Award Paper $1,000
Title of Grant
“The Effect of Nitric Oxide on Intramedullary Vascularity and Fracture Healing”
Grant Funded by
OTA
Principal Investigator
James Meeker, M.D.
Amount Funded
$10,000
Co-Investigator
Laurence Dahners, M.D.
Amount and Date Funded
$10,000 January 2007
Presentations
Publications
Additional Grants and Awards
Project Status
2008 – No update received.
Title of Grant
“The Influence of Racial and Economic Factors on the Treatment of Pediatric Fractures of
the Wrist and Forearm”
Grant Funded by
OTA
Principal Investigator
Matthew Oetgen, M.D.
Amount Funded
$10,000
Co-Investigator
Michael Baumgaertner, M.D.
Amount and Date Funded
$10,000 January 2007
Presentations
Publications
Additional Grants and Awards
Project Status
2008 – Update not received.
Title of Grant
“Use of Continuous Passive Motion in the Post-Operative Treatment of Intra-Articular Knee Fractures”
Grant Funded by
OTA
Principal Investigator
Jason Palmer, MD
Amount Funded
$10,000
Co-Investigator
Kyle Jeray, MD
Amount and Date Funded
$10,000 January 2007
Presentations
Publications
Additional Grants and Awards
Project Status
2008 – Update not received.
Title of Grant
“The Role of Muscle Function In Fracture Healing”
Grant Funded by
OTA
Principal Investigator
Scott Ruhlman, MD
Amount Funded
$10,000
Co-Investigator
Sean Nork, MD
Amount and Date Funded:
$10,000 January 2007
Presentations
March 2008 Poster Presentation - ORS
The work resulted in an abstract that was presented as a poster at the ORS in 2008. The title was: “Muscle Function is Critical for Successful Fracture Healing”. His co-authors were Gross, Asuk, Becker, Nork, Bain. This manuscript was also presented locally for Dr. Ruhlman’s resident research project.
Publications
This research has not resulted in publication directly as yet. However, it is a critical component of the upcoming
manuscript(s) on muscle function and fracture healing. The manuscript in preparation is “Transient muscle paralysis
impairs the osteogenic response to injury”.
Additional Grants and Awards
This research has continued to be an important part of the research lab at the University of Washington. The initial work by Dr. Ruhlman looking at transient muscle paralysis and fracture healing has resulted in ongoing studies funded by the Ted Hansen Chair, the Foundation for Orthopaedic Trauma, and Industry (Zimmer, Synthes).
Project Status
2008 – Grant extension approved to December 2008.
2010 - Completed
Title of Grant
“The Effects of Mediators on Vascular Permeability
in Ischemia-Reperfusion Injury”
Grant Funded by
OTA
Principal Investigator
Nicholas Souder, MD
Amount Funded
$10,000
Co-Investigator
Robert Probe, MD
Amount and Date Funded
$10,000
January 2007
Presentations
OTA Annual Meeting Poster Presentation, October
2007
Publications
J Bone Joint Surg Am. 2009 Nov;91(11):2637-45
Additional Grants and Awards: No
Project Status
2008 – Project
completed.
2006
OTA 2006 GRANT AWARDS
(Grant Cycle: January 1, 2006 – December 31, 2006) |
Title of Grant
“Fluid Irrigation Techniques in Patients with Open Fracture Wounds: A Multi-Center Blinded Randomized Controlled Trial (F.L.O.W.) A Pilot Study”
Grant Funded by
OTA/DePuy, a Johnson & Johnson Company
Principal Investigator
Mohit Bhandari, MD
Co-Investigator
Emil H. Schemitsch, MD
Amount and Date Funded
$25,000/year for 2 years – January 2006 and January 2007
Presentations
Abstract submitted to AAOS - pending
Plan to submit abstracts to COA and OTA - pending
Publications
1. Petrisor, B., Jeray, K., Schemitsch, E., Hanson, B., Sprague, S., Sanders, D. Bhandari, M.; FLOW Investigators. Fluid lavage in patients with open fracture wounds (FLOW): An international survey of 984 surgeons (BMC Musculoskeletal Disorders.
2008 Jan 23; 9:7.
2. Pending publications: The Journal of Bone and Joint Surgery, American Volume
Additional Grants and Awards
Yes. The results of the pilot study demonstrated the feasibility and need for a definitive study. A multi-centre clinical trial is currently underway. The funding for the FLOW definitive study is:
U.S. Department of Defense $950,000 USD Sept. 2008 - June 2010
CIHR $1.75 million CAD Jan. 2009 - Jan. 2012
Project Status
2007 Update not received.
2008 Update not received.
2009 Update received. Project is concluded.
Title of Grant
“The Role of Parathyroid Hormone in the Mechanosensitivity of Fracture Healing”
Grant Funded by
OTA/Stryker
Principal Investigator
Michael J. Gardner, MD
Co-Investigator
Joseph M. Lane, MD
Amount and Date Funded:
$25,000 January 2006
Presentations
Orthopaedic Trauma Association, October 2007
Orthopaedic Research Society, February 2007
Publications
Journal of Orthopaedic Research, November 2007 (in press)
Additional Grants and Awards
None
Project Status
Project Completed
Title of Grant
“Investigation of Stem Cells in the Management of Atrophic Nonunions”
Grant Funded by
OTA/Medtronic
Principal Investigator
David J. Hak, MD
Amount and Date Funded
$25,000 January 2006
Presentations
None
Publications
None
Additional Grants and Awards
AIOD - $50,000 2006
Project Status
Project Ongoing
2008- Project Complete
Title of Grant
“Effect Of IGF-1 and Range of Motion on Articular Cartilage After Fracture”
Grant Funded by
OTA/EBI
Principal Investigator
Thomas F. Higgins, MD
Co-Investigator
Brian D. Johnson, MD
Amount and Date Funded
$25,000 January 2006
Presentations
OTA Annual Meeting, October 2006
Publications
Manuscript submitted to OTA. Further publications pending.
Publications submitted to JOR -2008.
Additional Grants and Awards
1GF-1 Intra-articular FX 33,000 2006-2007
Project Status
Ongoing – Excellent progress made on two fronts with research on effects of IGF-1 on
cartilage repair after intra-articular fracture. Proceeding in second phase.
Title of Grant
“Anabolic Mechanisms of PTH During Fracture Repair”
Grant Funded by
OTA
Principal Investigator
Sanjeev Kakar
Co-Investigator
Paul Tornetta, III
Amount and Date Funded
$25,000 January 2006
Presentations
None
Publications
None
Additional Grants and Awards
Yes- Preliminary data being used as supportive data for a NIH grant
Project Status
2007 – Update not received
2008 – Project Ongoing
Title of Grant
“A Prospective, Randomized, Double-Blind Placebo-Controlled Study of the Effects of
Risedronate (Actonel®) on Fracture Healing in Elderly Patients with Intertrochanteric
Hip Fractures”
Grant Funded by
OTA/Smith & Nephew
Principal Investigator
Melvin P. Rosenwasser, MD
Co-Investigator
Brian W. Su, MD
Amount and Date Funded
$25,000/year for 2 years – January 2006 and January 2007
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
Project Ongoing
Title of Grant
“A Prospective Randomized Trial Investigating the Effect of a Novel Reamer-Irrigator-
Aspirator on the Incidence of Fat Embolism and Respiratory Function During Intramedullary Nailing of Femoral Shaft Fractures”
Grant Funded by
AO North America
Principal Investigator
Emil H. Schemitsch, MD
Co-Investigator
Michael D. McKee, MD
Amount and Date Funded
$25,000 Jan. ’06 and $24,000 Jan. ’07
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
2007 – Report not received as of October 2007.
2008 – Report not received as of October 2008.
2009 - Report received. The RIA study is a multi-centre trial with a principle site (St. Michael's Hospital) and an additional five participating co-invesitgative sites. Go to multi-centre project report for additional information: http://www.ota.org/research/res_multicenter.html
Title of Grant
“Radiation Prophylaxis for Post-Traumatic Heterotopic Ossification of the Elbow”
Grant Funded by
Synthes
Principal Investigator
Michael J. Bosse, MD (replacing Douglas Stull, MD)
Amount and Date Funded
$25,000 January 2006 and $24,218 January 2007
Presentations
None
Publications
Publication pending completion of patient enrollment
Additional Grants and Awards
Health Services Foundation - $32, 640.00
Project Status
2008 Project Ongoing
2009 Project Ongoing
OTA 2006 RESIDENT $10,000 GRANT AWARDS
(Grant Cycle: June 1, 2006 – May 31, 2007) |
Title of Grant
“The Effects of Methylprednisolone on Neurotrophic Cytokines in an Acute Spinal Cord
Injury Model”
Grant Funded by
OTA & FOT
Principal Investigator
Del Gaizo Daniel
Co-Principal Investigator
Douglas Dirschl
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
None
Publications
None
Additional Grants and Awards
Project Status
In final stages of data collection. Anticipated completion and manuscript submission is
planned for September 30, 20007.
Title of Grant
“Immunosuppression in Traumatic Open Fracture”
Grant Funded by
OTA & FOT
Principal Investigator
Brock Lindsey
Co-Principal Investigator
David Hubbard
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
OTA Annual Meeting, October 2007
American Academy of Orthopaedic Surgeons (poster) March 2008
Orthopaedic Research Society (podium) March 2008
Publications
Journal of Orthopaedic Research (2 papers) accepted July 2009 - in press
Additional Grants and Awards
A Pilot Study of Interleukin - 12 local Delivery for Infection Prevention After a Traumatic Open Fracture
$100,151 Funding Cycle: 8/1/07 - 7/31/09
Project Status
Project Concluded
Title of Grant
“Predictors of Outcome in Floating Elbow and Floating Elbow Variant Type Injuries”
Grant Funded by
OTA & FOT
Principal Investigator
Robert Golden
Co-Principal Investigator
Jesse Jupiter
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
New England Orthopaedic Society, November 2006
New England Orthopaedic Society, 2007
Publications
Pending
Additional Grants and Awards
None
Project Status
Project Ongoing. The project will continue to acquire data and hopefully result in future
publications. Unfortunately, patient recruitment for the study has been extremely difficult to this point. This issue has attempted to be addressed by sending out multiple mailings to potential subjects, as well as following up on these mailings with phone calls. The database from which potential subjects are drawn was also expanded by looking further back in hospital records using billing data to identify potential subjects who sustained their injuries prior to the implementation of the currently used prospective patient tracking database. In addition, an addendum to the study protocol is in the process of being evaluated by our IRB to make participation in the study more convenient for patients in order to boost recruitment. A collaboration has also been formed with a trauma center in Argentina to help increase available patient data. It is hoped that with the addition of more data, significant conclusions will be reached resulting in future publications.
July 2009 - Ongoing
Title of Grant
“Loss of Wire Tension with Cyclical Loading in Ilizarov and Taylor Spatial Frame (TSF)
Rings”
Grant Funded by
OTA & FOT
Principal Investigator
Elliott Vann
Co-Principal Investigator
Roman Hayda
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
None yet. Awaiting final data analysis – data collection is complete
Publications
None
Additional Grants and Awards
None
Project Status
Project Ongoing
Title of Grant
“A Cadaveric Injection Study of the Distal Femur Using a Soft-Tissue Sparing Lateral Approach”
Grant Funded by
OTA & FOT
Principal Investigator
Corey Van Hoff
Co-Principal Investigator
Laura Phieffer
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
Project Ongoing.
Title of Grant
“Comparative Performance of Locked and Conventional Plating Constructs in Composite Bone”
Grant Funded by
OTA & FOT
Principal Investigator
Benjamin Burkett
Co-Principal Investigator
David Seligson
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
AIOD-GKS Combined Meeting, Strasbourg, France, September 2007
Publications
Journal of Orthopaedic Trauma, December 2006
Additional Grants and Awards
None
Project Status
Project Ongoing
Title of Grant
“Ulnar Nerve Transposition During ORIF of Distal Humerus Fractures: Comparison of
functional outcomes between patients who were treated with ulnar nerve transposition and
those who were not”
Grant Funded by
OTA &FOT
Principal Investigator
Oscar Vazquez
Co-Principal Investigator
Kenneth Egol
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
Annual OTA meeting Boston - October 2007
Publications
Will be submitted to JBJS and other journals- April 2008
Fate of Ulnar Nerve after ORIF of distal humerus fractures
2008 Pending: Final paper to be submitted
Second abstract submitted to AAOS for 2009
Additional Grants and Awards
None
Project Status
2007 – Update not received as of October 2007
2008 – Ongoing project
Title of Grant
“Osteoblast Responses to Fracture: A novel approach using gene expression microarray and proteomics”
Grant Funded by
OTA & FOT
Principal Investigator
Andrew Evans
Co-Principal Investigator
Robert Simpson
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
PublicationsAdditional Grants and Awards Project Status
2007 – Update not received as of October 2007.
2008 – Update not received as of October 2008.
Title of Grant
“Accuracy of Radiographic Interpretation of Pelvic Ring Displacement”
Grant Funded by
OTA & FOT
Principal Investigator
Hobie Summers
Co-Principal Investigator
Michael Stover
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
None at this time. Do anticipate some in the future
Publications
None
Additional Grants and Awards
Yes – Charlotte Mecklenburg Foundation for $10,000.
Project Status
2007 – Ongoing project.
2008 – Project ongoing. The computer application portion has been completed and currently working
on the data collection process.
Title of Grant
“The Impact of Antegrade Intramedullary Reaming on Bacterial Persistence in Open
Femur Fractures”
Grant Funded by OTA & FOT
Principal Investigator James Romanowski
Co-Principal Investigator Michael Archdeacon
Amount and Date Awarded
$10,000 June 1, 2006
Presentations
University of Cincinnati Annual Research Day, 05/05/07
Submitted to 2008 AAOS Academy Meeting, 03/2008
2008 Mid-America Orthopaedic Annual Meeting Presentation 04/2008
Will Submit to 2009 OTA Annual Meeting
Publications
Submission JOT Pending, Manuscript Completed
Additional Grants and Awards
Project Status
Project Concluded
2005
OTA 2005 GRANT AWARDS
(Grant Cycle: January 1, 2005 – December 31, 2005) |
Title of Grant
“Objective Assessment of Injury Severity in Complex Intra-Articular Fractures”
Grant Funded by
OTA & Smith + Nephew
Principal Investigator
Donald D. Anderson, PhD Co-Investigator J. Lawrence Marsh, MD
Amount and Date funded
$25,000 January 2005
Presentations
XXth Congress of the International Society of Biomechanics, August 2005
52nd Annual Meeting of the Orthopedic Research Society, March 2006
2006 Midwest Graduate Student Biomechanics Symposium, March 2006
30th Annual Meeting of the American Society of Biomechanics, September 2006
31st Annual Meeting of the American Society of Biomechanics, August 2007
6th Combined Meeting of the Orthopaedic Research Societies, October 2007
Basic Science Focus Forum, 23rd Annual OTA Meeting, October 2007
23rd Annual Meeting of the OTA, October 2007
54th Annual Meeting of the Orthopaedic Research Society, March 2–5, 2008,
San Francisco, California
75th Annual Meeting of the American Academy of Orthopaedic Surgeons,
March 5–9, San Francisco, California
24th Annual Meeting of the Orthopaedic Trauma Association, Denver, Colorado, October 15-18, 2008
Publications
Journal of Orthopaedic Research, March 2005, vol. 23(3): 686-690
Journal of Orthopaedic Research, 26(8):1046-1052, 2008
Additional Grants and Awards
NIH and AO Research Fund
Continuing line of research with funding from the World Arthrosis Organization and the
NIH/NIAMS (an Anderson PI R21 and a Marsh PI project within a P50 CORT grant).
Project Status
Pending Grant: NIHR21 on Assessing Bone Fragment Displacement
Submitted 10/01/2006
Pending Grant: NIHR21, CORT Proposal, Project 4, Quantifying Injury Severity to
Assess Risk for Post-Traumatic OA
2006 – Project Ongoing
2007 – Project Ongoing. Publication submitted to Journal of Orthopaedic Research July of 2007. Funding decision award due to high score is pending.
2008 – Concluded
Title of Grant
“A Prospective Randomized Multicentre Clinical Trial Comparing ORIF with Primary Subtalar Fusion in Patients with Severely Comminuted (Sanders IV), Displaced, Intra-articular Fractures of the Calcaneus”
Grant Funded by
OTA & AO North America
Principal Investigator
Kelly D. Johnston, MD
Co-Investigator
Richard E. Buckley, MD
Amount and Date funded
$25,000 January 2005
Presentations
Too early - RCT
Publications
Too early - RCT
Additional Grants and Awards
None
Project Status
2005 – Project Ongoing.
2006 – Project Ongoing
2007 – Project Ongoing
2008 – Project Ongoing
Title of Grant
“A Multicenter, Prospective ,Randomized Trial of Non-Operative Versus Operative
Treatment For High- Energy Midshaft Clavicle Fractures”
Grant Funded by
OTA & Synthes
Principal Investigator
Kyle J. Jeray, MD
Co-Investigator
J. Scott Broderick, MD
See Jeray 2004 for report.
Title of Grant
“The Effect of Ischemia on Murine Fracture Repair”
Grant Funded by
OTA & Zimmer
Principal Investigator
Ralph S. Marcucio, PhD
Co-Investigator
Theodore Miclau, III, MD
Amount and Date funded
$25,000 January 2005
Presentations
ORS Annual Meeting, March 2008
ORS Annual Meeting, March 2007
ORS Annual Meeting, March 2006
Publications
Journal of Orthopaedic Research 25(1):51-61, Ischemia Leads to Delayed Union during Fracture Healing:
A Mouse Model, June 2006
28 Iowa Journal, 2008, Tibial fracture decreases oxygen level a th the site of injury
Journal of Orthopaedic Research, 26(10): 1384-9, May 2008, Effect of age on vascularization during fracture repair
Additional Grants and Awards
2008 - None. However, larger grant is still pending as of July 2007.
2009 - Yes, $25,000 award, 1/2007-12/2007 - Effects of rhBMP7 on fracture healing in an ischemic environment
Project Status
2006 – Project Ongoing July 1, 2006: Mechanisms underlying ischemia – induced impairments in fracture healing.
2007 – Project Concluded.
2009 - Project Concluded.
Title of Grant
“Preoperative Hypertonic Saline Attenuates Postoperative Polymorphonuclear Neutrophils Priming Following Reamed Intramedullary Rod Fixation of Femoral Fractures”
Grant Funded by: OTA & DePuy, a Johnson & Johnson Co.
Principal Investigator
Wade R. Smith, MD
Co-Investigator
Steven J. Morgan, MD
Amount and Date funded
$24,546 January 2005
Presentations
OTA Annual Meeting Denver, 2008
Publications
Submission for Journal of Orthopaedic Trauma for 2008 publication
Submission to OTA for 2008 Annual Meeting
Additional Grants and Awards
OREF Grant to study this data as pilot for large study
Project Status
2005 – Project Ongoing.
2006 – Project delayed. Beginning June 2006.
2007 – Anticipated Conclusion – December 2007
2008 – Project Completed
Title of Grant
“Effect of OP-1 on Gene Expression in Chronically Infected Femoral Segmental Defect
in the Rat”
Grant Funded by
OTA & Stryker Orthopaedics
Principal Investigator
Andrew H. Schmidt, MD
Co-Investigator: Xinqian Chen, MD
Amount and Date funded
$25,000 January 2005
Presentations
Orthopaedic Research Society 50th Annual Meeting
ORS abstract to be submitted for the 2007 ORS meeting.
Publications
A paper is being written for submission to Journal of Orthopaedic Research or Journal of Orthopaedic Trauma.
Journal of Orthopaedic Trauma – Completed, review process, in press to appear in 2007
Clinical Orthop Rel Res - in press 2009. - Brick KE, Chen X, Lohr J, Schmidt AH, Kidder LS, Lew WD. rhBMP - 2 Modulation of Gene Expression in Infected Segmental Bone Defects.
Additional Grants and Awards
Grant Award/Title: Midwest Orthopaedic Research Foundation
Amount Awarded: $10,586.87
Funding cycle: Jan. 1, 2006 – July 31, 2006.
New Bone Formation in Chronically, Infected Segmented Defect in the 1st Femur treated with BMP-2 and Local Antibiotic – Dept.of Defense $466,644 11/1/07-12/31/07
Polymicrobial Chronic Infection – Dept. of Defense $418,647 1/1/07-12/31/07
Project Status
2006 – Project Completed, but data analysis is in progress.
2007 – Project Complete.
Title of Grant
“Effects of Bisphosphonates and Parathyroid Hormone (PTH) in an Osteoporotic Fracture Healing Rodent Model”
Grant Funded by
OTA & EBI, a Biomet Company
Principal Investigator
Jose B. Toro
Co-Investigator: Joseph M. Lane, MD
Amount and Date funded
$25,000 January 2005
Presentations
Publications
Additional Grants and Awards Project Status
2007 - Update not received.
2008 - Update not received.
2004
OTA 2004 GRANT AWARDS
(Grant Cycle: January 1, 2004 – December 31, 2004) |
Title of Grant
“LMP Gene Transfer for Improvement of Bone Formation and Regeneration in an
Animal Model”
Grant Funded by
OTA & Stryker Howmedica Osteonics
Principal Investigator
Gary S. Gruen, MD
Project Status
Research project cancelled. Grant funding returned ($18,893.00)
Title of Grant
“The Effect of Cyclooxygenase-2 Inhibitors on Primary (Direct) Bone Healing”
Grant Funded by
OTA & Smith + Nephew Orthopaedics
Principal Investigator
David J. Hak, MD
Amount and Date funded
$25,687 January 2004
Presentations
ORS Annual Meeting, March 2006
Publications
In preparation, hopefully to be submitted to J. Orthopaedic Research in August 2006.
Additional Grants and Awards
None
Project Status
2005 – Project concluded. Manuscript is in preparation.
2007 – Manuscript completed; but not yet accepted.
2008 – Manuscript being revised for submission.
2009 - Manuscript resubmitted to Journal of Orthopaedic Trauma in July 2009.
Title of Grant
“A Multicenter Prospective Randomized Trial of Non-Operative versus Operative
Treatment for High Energy Mid-Shaft Clavicle Fractures”
Grant Funded by
OTA & Synthes USA
Principal Investigator
Kyle J. Jeray, MD
Amount and Date funded
$20,000 January 2004
$25,000 January 2005
Presentations
None
Publications
None
Additional Grants and Awards
Grant/Award Title: OTA
Amount Awarded: $25,000
Funding Cycle: 2005
Project Status
2005 – Ongoing. This study is still enrolling patients. Once the study has been completed we expect multiple publications. As enrollment continues, and once preliminary analysis has been done, we intend on submitting for additional research grants.
2006 – Ongoing. This study is still open and actively enrolling patients.
2007 – This study is still ongoing and actively enrolling patients.
2008 – This study is still ongoing and actively enrolling patients.
2009 - 11 sites enrolling patients. Once the study is concluded, it wil be submitted for publication.
Title of Grant
“Percutaneous Pinning vs. Open Reduction and Internal Fixation of Proximal
Humeral Fractures: A Prospective and Randomized Comparison of Outcomes”
Grant Funded by
OTA & DePuy Ace, a Johnson & Johnson Co.
Principal Investigator
Sean E. Nork, MD
Project Status
October 2005 – research project canceled. Money returned to the OTA Research Fund.
Title of Grant
“Prospective Randomized Study of Internal Fixation vs. External Fixation of Distal Tibia
Plafond Fractures”
Grant Funded by
OTA & AO North America
Principal Investigator
William T. Obremskey, MD, MPH
Amount and Date funded
$48,900 January 2004
Presentations
OTA Annual Meeting, Oct. 2006
Publications
Journal of Orthopaedic Trauma, Dec. 2007 (pending)
Additional Grants and Awards
None
Project Status
2006 – Project Ongoing.
2008 – Project Concluded
2003
OTA 2003 GRANT AWARDS
(Grant Cycle: January 1, 2003 – December 31, 2003) |
Title of Grant
“The Role of Anabolic Supplementation to Enhance Soft Tissue Envelope in Fracture
Healing”
Grant Funded by
OTA & EBI/Biomet
Principal Investigator
Jeffrey O. Anglen, MD
Amount and Date funded
$19,536 January 2003
Presentations
OTA Annual Meeting, October 2004
Comparative Orthopaedic Lab Day – University of Missouri, April 2004
21st OTA Annual Meeting, October 2005
OTA Specialty Day (AAOS Annual Meeting Chicago), March 2006
Publications
JBJS-AM
Additional Grants and Awards
None
Project Status
2005 – Project ongoing. Publications pending.
2006 – Project concluded.
Title of Grant
“Lower Extremity Driving Performance Following Complex Lower Extremity Trauma”
Grant Funded by
OTA/Smith & Nephew Orthopaedics
Principal Investigator
Kenneth A. Egol, MD
Amount and Date funded
$19,428 January 2003
Presentations
Orthopaedic Trauma Association, October 2005
AAOS, March 2006
Publications
Journal of Trauma, 2008, 65(6) 1435-38
Additional Grants and Awards
None
Project Status
2005 – Project concluded.
Title of Grant
“Biphasic Sustained Release of Antibiotics and OP-1 at the Site of Segmental Femoral
Defects in Adult Male Rats”
Grant Funded by
OTA/AO North America
Principal Investigator
Ham A. Benghuzzi
Amount and Date funded
$20,000 January 2003
Presentations
Rocky Mountain Bioengineering Symposium, April 2003
Academy of Surgical Research, October 2003
Academy of Surgical Research, October 2004
Society for Biomaterials (Abstract), May 2004
Publications
Journal of Investigative Surgery; Submitted November 2004 (Pending)
Journal of Orthopaedic Trauma; Submitted November 2004 (Pending)
Journal of Investigative Surgery. 2007 Jul-Aug;20(4):249-55.
Journal of Investigative Surgery. 2007 May-Jun;20(3):149-55
Biomed Scientific Instruments. 2007;43:194-199.
Biomed Scientific Instruments 2007;43:188-93.
Additional Grants and Awards
NIH Area Grant; Submitted January 2004 (Pending)
Isotis; Submitted August 2004 (Pending)
Isotis Received 2007
NIH Proposal Submitted 2007
NIH Proposal to be Submitted Feb. 2008
Project Status
Project Concluded
Title of Grant
“The Analysis of Distraction Osteogenesis Using the COX-1 and COX-2 Knockout
Mouse Model”
Grant Funded by
OTA/Zimmer
Principal Investigator
John T. Gorczyca, MD
Amount and Date funded
$13,309 January 2003
Presentations
OTA Basic Science Forum, October 2005.
Publications
None
Additional Grants and Awards
None
Project Status
2006 – Project concluded.
Title of Grant
“Linking Scores of the Sickness Impact Profile and Short Musculoskeletal Function
Assessment Scales: A Prospective Study”
Grant Funded by
OTA/Synthes, USA
Principal Investigator
Ricardo Pietrobon, MD
Amount and Date funded
$19,890 January 2003
Presentations
Not yet
Publications
JBJS (accepted for 2004)
Journal of Physical Activity and Health, April 2004 v. 1(2)
Additional Grants and Awards
Pending Grant: NIH June 2004
Pending Grant: OREF October 2004
Project Status
2006 – Report not received
2007 – Report not received
2008 – Report nor received
Title of Grant
“Orthopaedic Trauma Assessment Instrument Generated Using Item Response Theory”
Grant Funded by
OTA/Stryker Howmedica Osteonics
Principal Investigator
Mark S. Vrahas, MD
Amount and Date funded
$16,239 January 2003
Presentations
AAOS Annual Meeting, March 2004
OTA Annual Meeting, October 2004
Publications
ABJS, Sept. 2006; 88: 1927-1933
Additional Grants and Awards
Applied for OREF Grant in October 2004.
Pending: Computed adapted testing for Trauma Outcomes, tentatively funded by AO Foundation, currently working out IP issues.
Project Status
2003 - Ongoing
2004 – Project concluded.
Title of Grant
“Intracellular Staphylococcus Aureus: A Proposed Mechanism for the Indolence of
Osteomyelitis”
Grant Funded by
OTA/DePuy Ace, a Johnson & Johnson Co.
Principal Investigator
Lawrence X. Webb, MD
Amount and Date funded
$19,910 January 2003
Presentations
AAOS, February 2003; OTA Annual Meeting, October 2003; Nanotechnology Conference, December 2004; NCOA, June 2006; OTA Annual Meeting, October 2006, Orthopaedic Research Society (podium) Feb. 2009; FASEB (poster) - April 2009
Publications
Osteomyelitis and intraosteopblastic Staphylococcus Aureus, 2007 16:73-78
Encapsulated Staphylococcus aureus Strains vary in adhesiveness assessed by atomic force microscopy,
May 2009, 89:402-410
Journal of Bone & Joint Surgeons, vol. 85, August 2003
Journal of Orthopaedic Research, January 2006
Additional Grants and Awards
Grant/Award Title: OREF "Targeting the glycocalyx to reduce bone/implant related
infections"
Amount Awarded: $98,202 Funding Cycle: July 1, 2006 - June 30, 2009
Grant/Award Title: Translational Science Institute Wake Forest University School of Medicine, "The use of nanoparticles to target osteomyelitis", $50,000,
Funding Cycle
January 2008 - December 2009
Project Status
2006 – Project concluded.
2009 - Intracellular bacteria in osteoblasts cultured from patients with osteomyelitis in preparation for submission in September of 2009.
2002
OTA 2002 GRANT AWARDS
(Grant Cycle: January 1, 2002 – December 31, 2002) |
Title of Grant
“The Role of Anabolic Supplementation to Enhance Soft Tissue and Fracture Healing”
Grant Funded by
OTA/EBI
Principal Investigator
Timothy A. Burd, MD
Amount and Date funded
$19,971 January 2002
Presentations
ISFR, October 2002
Publications
Journal of Bone and Joint Surgery American, November 2006
Additional Grants and Awards
Submitted
Project Status
Project Concluded
Title of Grant
“The Effect of Low Molecular Weight Heparin on Fracture Healing in a Standardized Rat
Femur Fracture Model”
Grant Funded by
OTA/AO North America
Principal Investigator
David J. Hak, MD
Amount and Date funded
$14,651 January 2002
Presentations
International Society for Fracture Repair, October 2002; Orthopaedic Research Society, February 2003; AAOS Annual Meeting, February 2003
Publications
Journal of Orthopaedic Research, 2006; 24(4):645-652
Additional Grants and Awards
No
Project Status
Project Concluded
Title of Grant
“Do Variations in Pulsatile Lavage Pressure Affect Cancellous Bone Structure and
Fracture Healing”
Grant Funded by: OTA/Stryker Howmedica Osteonics
Principal Investigator
Douglas R. Dirschl, MD
Amount and Date funded
$19,872 January 2002
Presentations
None
Publications
Journal of Orthopaedic Trauma, 2006, 20:261-266
Additional Grants and Awards
None
Project Status
Animal surgery finished 5/02. Data analysis ongoing.
2003 – Project concluded.
Title of Grant
“Use of Direct BMP-2 Gene Delivery to Enhance the Healing of Segmental Bone
Defects: Evaluation in a Rat Model”
Grant Funded by
OTA/Synthes
Principal Investigator
Christopher H. Evans, MD
Amount and Date funded
$20,000 January 2002
Presentations
Orthopaedic Research Society, 2003 (New Orleans)
Publications
Journal of Bone & Joint Surgeons, vol. 88-A #2, Feb. 2006
Additional Grants and Awards
Based upon the preliminary data obtained with our OTA grant, we have secured a 5-year RO1 grant from NIAMS (AR 050243)
Project Status
2002 - Work has been in progress for 7 months, and great data is being received.
However, it is too soon to publish or present, or secure further funding.
Project Concluded.
Title of Grant
“Comparison of IMN vs. Cast in Stable Tibia Fractures”
Grant Funded by
OTA/DePuy Ace
Principal Investigator
William T. Obremskey, MD
Amount and Date funded
$48,377 January 2002
Presentations
OTA Annual Meeting, Oct. 2006
Publications
Journal of Orthopaedic Trauma, Dec. 2007 (pending)
Additional Grants and Awards
None
Project Status
Animal surgery finished 5/02. Data analysis ongoing.
2005 – Project ongoing.
2006 – Project ongoing.
2008 – Project complete.
Title of Grant
“Study to Prospectively Evaluate Reamed Intramedullary Nailing in Tibial Fractures: A
Multi-Center Randomized Trial”
Grant Funded by
OTA/AO North America
Principal Investigator
Gordon Guyatt, MD
Amount and Date funded
$50,000 January 2002
Presentations
AAOS Annual Meeting, San Francisco, California, March 2004
Publications
Controlled Clinical Trials, 2003
Sprint Manuscripts Accepted for Publication
— S.P.R.I.N.T. Investigators. Randomized Trial of Reamed versus Non-Reamed Intramedullary Nailing of Tibial Shaft Fractures. J Bone Joint Surg Am. In Press, December 2008.
— S.P.R.I.N.T. Investigators. Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients with Tibial Fractures (S.P.R.I.N.T.): Study Rationale and Design. BMC Musculoskelet Disord. 2008, 9:91 (23 Jun 2008). *Recipient of the International Society for Fracture Repair (ISFR) 2008 Best Paper Award.
Presented SPRINT Abstracts
— S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Orthopaedic Trauma Association (OTA) 23rd Annual Meeting, Boston, MA, October 2007.
— S.P.R.I.N.T. Investigators. (Tornetta, P). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Functional Outcome in Patients with Fractures of the Tibia. Orthopaedic Trauma Association (OTA) 23rd Annual Meeting, Boston, MA, October 2007.
— S.P.R.I.N.T. Investigators. (Bhandari, M). Reamed versus Non-Reamed Tibial Intramedullary Nail Insertion on Re-operation Rates. American Academy of Orthopaedic Surgeons (AAOS) 75th Annual Meeting, San Francisco, CA, March 2008.
— S.P.R.I.N.T. Investigators. (Sanders, D). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. American Academy of Orthopaedic Surgeons (AAOS) 75th Annual Meeting, San Francisco, CA, March 2008.
— S.P.R.I.N.T. Investigators. (Swiontkowski, MF). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Mid-American Orthopaedic Association 26th Annual Meeting, Champions Gate, FL, April 2008.
— S.P.R.I.N.T. Investigators. (Goslings, JC). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Functional Outcome in Patients with Fractures of the Tibia. Dutch Association for Trauma Surgery Annual Meeting, Netherlands, November 2007.
— S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. Canadian Orthopaedic Association (COA) 63rd Annual Meeting, Quebec City, QC, June 2008.
— S.P.R.I.N.T. Investigators. (Schemitsch, E). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. Canadian Orthopaedic Association (COA) 63rd Annual Meeting, Quebec City, QC, June 2008.
— S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. 81st Annual Congress of the Japanese Orthopaedic Association, Sapporo, Japan, May 2008.
— S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) 9th Annual Congress, Nice, France, May/June 2008.
— S.P.R.I.N.T. Investigators. (Bhandari, M). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. European Federation of National Associations of Orthopaedics and Traumatology (EFORT) 9th Annual Congress 2008, Nice, France, May/June 2008.
— S.P.R.I.N.T. Investigators. (Bhandari, M). A Randomized Trial of Reamed versus Non-Reamed Intramedullary Nail Insertion on Rates of Re-operation in Patients with Fractures of the Tibia. International Society for Fracture Repair (ISFR) Biennial Meeting 2008, Lake Tahoe, CA, July 2008.
— S.P.R.I.N.T. Investigators. (Bhandari, M). Functional, General, and Disability Outcomes after Tibial Nailing: A Randomized Trial. International Society for Fracture Repair (ISFR) Biennial Meeting 2008, Lake Tahoe, CA, July 2008.
Accepted SPRINT Abstracts
— S.P.R.I.N.T. Investigators. (Busse, J). A Comparison of the Discriminative Ability and Responsiveness of the Short Musculoskeletal Function Assessment Questionnaire Function Index and the Short Form-36 Physical Summary Score among Tibial Fracture Patients. Orthopaedic Trauma Association (OTA) Annual Meeting 2008, Denver, CO, October 2008.
Additional Grants and Awards
Grant/Award Title: OREF – for Sprint Economic Analysis
Amount Awarded: $100,000
Funding Cycle: July 2005 – June 30, 2007
Grant/Award Title: Canadian Institute of Health Research
Amount Awarded: $499,952 ($CAN)
Funding Cycle: April 2004 – March 2007
Grant/Award Title: National Institute of Health
Amount Awarded: $980,940
Funding Cycle: May 2002 –2005
Grant/Award Title: Canadian Institute of Health Research
Amount Awarded: $701,533 ($CAN)
Funding Cycle: April 2001 – March 2004
Grant/Award Title: Orthopaedic Research & Education Foundation
Amount Awarded: $100,000
Funding Cycle: July 2002 –2004
Grant/Award Title: Zimmer Orthopaedics
Amount Awarded: $34,125 ($CAN)
Funding Cycle: December 2000 – 2001
Grant/Award Title: Hamilton Health Sciences Corporation
Amount Awarded: $25,000 ($CAN)
Funding Cycle: October 2000 – 2001
Grant/Award Title: Medical Research Council
Amount Awarded: $90,988 ($CAN)
Funding Cycle: April 2000 – March 2001
Project Status
Project is still recruiting patients, and will not be completed until 2005.
2003 – Requested additional funding from CIHR for Canadian centers.
2004 – Project On-going. Several publications expected.
2005 – Recruitment has stopped, currently following patients.
2006 – Pending publications to be determined 2007 – Completed patient follow-up in 2006 - Primary paper draft completed with intent to submit it to journals in September
2008 – Update of the numerous publications and presentations resulting from this study record above. Continuing to conduct secondary analyses and expect additional publications and presentations over the next year.
Title of Grant
“Enhancement of Fracture Healing and BMP Induced Bone Formation by Traumatic
Brain Injury”
Grant Funded by
OTA/Synthes
Principal Investigator
Uwe Scherbel, MD
Amount and Date funded
$20,000 January 2002
Presentations
AAOS, February 2001; IBMS and ECTS, June 2001; OTA, October 2001 (poster);
OTA, October 2002 (poster)
Publications
Pending
Additional Grants and Awards
None
Project Status
2003 – Project ongoing
2008 – No additional updates received
Title of Grant
“Traumatic Brain Injury and Enhanced Osteogenic Potential in a Rat Model”
Grant Funded by
OTA/Zimmer
Principal Investigator
Paul Tornetta, III, MD
Amount and Date funded
$19,607 January 2002
Presentations
Orthopaedic Trauma Association, October 2004
AAOS Poster Presentation, February 2005
Publications
JBJS, 2007
Additional Grants and Awards
None
Project Status
2003 – ORS abstract submitted July 2003, manuscripts to be submitted to JOR or JBJS
upon completion (October).
2005 – Project Completed.
…………………………………………………………………………………………………………………………
2001
OTA 2001 GRANT AWARDS
(Grant Cycle: January 1, 2001 – December 31, 2001) |
Title of Grant
“A Multicenter, Prospective Randomized Trial of Non-operative and Operative
Treatment of Displaced Clavicular Shaft Fractures”
Grant Funded by
OTA/DePuy Ace, a Johnson & Johnson Company
Principal Investigator
Michael D. McKee, MD
Amount and Date funded
$20,000 January 2001
Presentations
Orthopaedic Trauma Association, October 2005
Publications
JBJS (A), January 2007
Additional Grants and Awards
Grant/Award Title: Zimmer Research Grant
Amount Awarded: $10,000
Funding Cycle: 2001 – 2003
2006 Specialty Day Edwin G. Bovill, Jr., MD Award
Project Status
2004 – 130 patients enrolled to date. Project concluded.
Title of Grant
“A Multicenter Prospective Randomized Trial of Open Reduction and Internal Fixation
vs. Total Elbow Arthroplasty for Severe Fractures of the Distal Humerus in Elderly
Patients”
Grant Funded by
OTA/Aventis Pharmaceuticals
Principal Investigator
Michael McKee, MD
Amount and Date funded
$20,000 January 2001
Presentations
OTA Annual Meeting, October 2006
Publications
JSES, 2007 (accepted for publication)
Additional Grants and Awards
Grant/Award Title: Zimmer Research Grant
Amount Awarded: $10,000 Funding Cycle: 2001 – 2003
OTA Edwin Bovill Award, 2007
ASES Neer Award, 2007
Project Status
Concluded
Title of Grant
“Treatment of Displaced Femoral Neck Fractures in the Elderly: An Outcome Study of
Patient Prospectively Randomized to Internal Fixation, Hemiarthroplasty or Total Hip
Replacement.”
Grant Funded by
OTA/Zimmer
Principal Investigator
Kenneth Egol, MD
Amount and Date funded
$25,000 January 2001
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
2002 - Project Not Concluded. Although funded in 2001, we didn’t get full IRB approval until 2002. Data collection began the end of Jan. 2002. In 5 months we have entered 15 patients so far.
2003 – Study has been discontinued and remaining funds returned because of the “STARS” trial.
2000
OTA 2000 GRANT AWARDS
(Grant Cycle: January 1, 2000 – December 31, 2000) |
Title of Grant
“Biodegradable Antibiotic Impregnated Rods for the Treatment of Osteomyelitis”
Grant Funded by
OTA/AONA
Principal Investigator
Jeffrey Anglen, MD
Amount and Date funded
$19,552 January 2000
Presentations
AOA Resident’s Conference, February 2000
Publications
Journal of Orthopaedic Trauma, vol. 15, Aug. 2001;
Clinical Orthopaedics and Related Research, vol. 441 (280-287), 2003
Additional Grants and Awards
None
Project Status
2001 – Project concluded
Title of Grant
“Apoptosis in Articular Cartilage Injury”
Grant Funded by
OTA/Ace DePuy
Principal Investigator
Joseph Borrelli, MD
Amount and Date funded
$19,581 January 2000
Presentations
Orthopaedic Trauma Association, October 2001
American Fracture Association, November 2001
Publications
Submitted to Journal of Orthopaedic Trauma, May 2002
Additional Grants and Awards
Plans are currently underway to develop a RO3 grant through the NIH. The specific aims of this grant will include determining mechanism of apoptosis and possible means of preventing apoptosis. The information gained from this investigation will provide pilot data for a larger investigation. Submitted 6/21/02
Project Status
Expected Publications – “Chondrocyte Apoptosis Following Impact Loading in an in-vivo Rabbit Model.”
“Mechanism of Chondrocyte Apoptosis Following Articular Injury.”
Pending Grants – This data will be included in an RO3 grant currently being developed.
2002 – Project Concluded.
Title of Grant
“The Effect of Tourniquet Control on Intramedullary Reaming”
Grant Funded by
OTA/Smith & Nephew Richards
Principal Investigator
Madhav A. Karunakar, MD
Amount and Date funded
$19,984 January 2000
Presentations
Orthopaedic Trauma Association, October 2002
American Association of Orthopaedic Surgeons, February 2003
Publications
Journal of Orthopaedic Trauma (provisionally accepted)
Additional Grants and Awards
Grant/Award Title: Best Poster, OTA Annual Meeting, October 2002
Project Status
2003 – Project concluded
Title of Grant
“Sprint – A Prospective MultiCenter Study of Reamed vs.Unreamed Tibial Nails”
Grant Funded by
OTA/AONA
Principal Investigator
Gordon H. Guyatt, MD
Amount and Date funded
$20,000 January 2000
Presentations
American Academy of Orthopaedic Surgeons Annual Meeting, San Francisco, California, March 2004 Publications Controlled Clinical Trials, 2003
Additional Grants and Awards
Grant/Award Title: OREF – Sprint Economic Analysis
Amount Awarded: $100,000
Funding Cycle: July 2005 – June 2007
Grant/Award Title: Canadian Institute of Health Research
Amount Awarded: $499,952 ($CAN)
Funding Cycle: April 2004 – March 2007
Grant/Award Title: National Institute of Health
Amount Awarded: $980,940
Funding Cycle: May 2002 –2005
Grant/Award Title: Canadian Institute of Health Research
Amount Awarded: $701,533 ($CAN)
Funding Cycle: April 2001 – March 2004
Grant/Award Title: Orthopaedic Research & Education Foundation
Amount Awarded: $100,000
Funding Cycle: July 2002 –2004
Grant/Award Title: Zimmer Orthopaedics
Amount Awarded: $34,125 ($CAN)
Funding Cycle: December 2000 – 2001
Grant/Award Title: Hamilton Health Sciences Corporation
Amount Awarded: $25,000 ($CAN)
Funding Cycle: October 2000 – 2001
Grant/Award Title: Medical Research Council
Amount Awarded: $90,988 ($CAN)
Funding Cycle: April 2000 – March 2001
Project Status
2001 – Project ongoing.
Pending grants: NIH – submitted June 2001; OREF * – submitted August 2001; OTA * – submitted August 2001; AO International * – submitted August 2001
* Submitted in case NIH funding is not granted.
2005 – Project ongoing. Multiple publications pending.
Title of Grant
“Characterization of Callous Mineralization and Collagen Using FT-IRI in the
Rabbit Ulna Model: The Effects of Rigid Fixation”
Grant Funded by
OTA
Principal Investigator
Joseph M. Lane, MD
Amount and Date funded
$14,825 January 2000
Presentations
Not yet
Publications
Not yet
Additional Grants and Awards
Grant/Award Title: NIH – Osteoporosis Collegen Cross-link and Biomechanics
Amount Awarded: $1,174,464
Funding Cycle: 9/28/01 – 7/31/04
Project Status
2000 - Pending Publication – When completed will be submitted to JOR and OTA
Pending Grants – NIH – Grant FTIR on FX Healing, Date submitted: 6/00
2001 – Project ongoing. Publications and related grants expected once completed.
2002 – Project ongoing. Awaiting Histology. Pending Publications: JOR, OTA
2003 – Due to construction in research facilities, FTIR was delayed. Anticipating concluding the study within the next 6 months.
2004 – New instrument will arrive on 9/1/04 to complete study.
Title of Grant
“Percutaneous Treatment of an Experimental Tibial Atrophic Non-Union: A Gene
Therapy Approach in a Rabbit Model”
Grant Funded by
OTA/AONA
Principal Investigator
Christian Lattermann, MD
Amount and Date funded
$19,984 January 2000
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
Pending Publication
Effect of BMP-2 & VEGF alone and in combination on the healing of an experimental non-union using a gene therapy approach.
Last update received in 2001.
Title of Grant
OTA/AONA Grant Expression of Indian Hedgehog and Bone Morphogenetic
Proteins in Rats at 6 and 32 Weeks of Age
Grant Funded by
OTA/AONA
Principal Investigator
Ralph A. Meyer, PhD
Amount and Date funded
$19,233 January 2000
Presentations
Orthopaedic Research Society, February 2001; International Bone and Mineral Society,
June 2001; Orthopaedic Trauma Association, October 2001; International Society for
Fracture Repair, October 2002; American Society for Bone and Mineral Research,
September 2002
Publications
Pending
Additional Grants and Awards
Grant/Award Title: DNA Microarray Facility/The Charlotte Genomics Consortium
Funding Cycle: July 2001 – June 2002
Amount Awarded: $223,000
Project Status
The experimental phase is completed. The data analysis continues and additional
manuscripts are expected.
Pending Publications: Bridging callus formation in adult rats with femoral fractures:
Expression of VEGF and FGF – 1and 2 but not Ihh and the BMPs. B.J. Desai, M.H.
Meyer, S. Porter, J.F. Kellam and R .A. Meyer, Jr. Submitted to JOT, July 2002.
Microarray analysis of femoral fracture in rats. The effect of age. R.A. Meyer, Jr., B.J.
Desai and M.H. Meyer. Data now being analyzed.
Title of Grant
“BMP Function in the Presence of Local Antibiotics”
Grant Funded by
OTA/Smith + Nephew
Principal Investigator
Steven Olson, MD
Amount and Date funded
$6,000 January 2000
Presentations
International BMP Symposium, June 2000
Publications
None
Additional Grants and Awards
None
Project Status
2001 – Project concluded
Title of Grant
“Can Topical Antiseptics or Antibiotics Normalize the Bacterial Count of
Superficial Dermal Abrasions, Effectively Extending the Safe Surgical Window
for Closed Fractures?”
Grant Funded by
OTA/Zimmer
Principal Investigator
Laura Senunas Phieffer, MD
Amount and Date funded
$26,774 January 2000
Presentations
Orthopaedic Trauma Association, October 2000; AAOS, March 2001
Publications
Publication in Journal of Orthopaedic Trauma. Date submitted: 8/01
Additional Grants and Awards
None
Project Status
2001 – Project Concluded.
Title of Grant
“Bone Morphogenetic Protein Treatment of the Infected Bone Defect”
Grant Funded by
OTA/Synthes USA
Principal Investigator
Andrew H. Schmidt, MD
Amount and Date funded
$18,263 January 2000
Presentations
24th Annual Meeting, American Society for Bone and Mineral Research, September 2002;
5th European Trauma Congress, Vienna, May 2002; 17th Annual Orthopaedic Trauma Association, October 2001 (poster); Orthopaedic Research Society 2003
Othopaedic Trauma Association, October 2001
Publications
Journal of Orthopaedic Trauma, vol. 18(7), page 436, 2004
Journal of Orthopaedic Research, vol. 23, p. 816, 2005
Additional Grants and Awards
NIH grant submitted 2003
Grant/Award Title: OTA/Effect of OP-1 on Gene Expression in Chronically
Infected Fractures
Funding Cycle: 2005 Amount Awarded: $25,000
Project Status
2005 – Project ongoing.
Pending Publication: JBJS Fall 2005.
Pending Grant: Medtronic, Fall 2005.
Title of Grant
“High Pressure Parallel Lavage for Wound Debridement: A Comparison of
Traditional Methods”
Grant Funded by
OTA
Principal Investigator
Lawrence X. Webb, MD
Amount and Date funded
$20,000 January 2000
Presentations
Poster, Orthopaedic Trauma Association, October 2000
Publications
Manuscript in preparation
Additional Grants and Awards
Pending Grants - no cost extension of unexpended funds to be requested from OTA to complete clinical study
1999
OTA 1999 GRANT AWARDS
(Grant Cycle: January 1, 1999 – December 31, 1999) |
Title of Grant
“Enhancement of Fracture Healing by a Marrow Osteogenic Cell Transfected with IGF-1”
Principal Investigator
David Diduch, MD
Amount and Date funded
$30,772 January 1999
Presentations
UVA Orthopaedic Alumni Meeting, November 1999; Virginia Orthopaedic Society, May
2000; Orthopaedic Trauma Association, October 2000
Publications
Pending: Journal of Orthopaedic Trauma
Additional Grants and Awards
Grant/Award Title: OREF: Articular Cartilage Repair Using Cells
Transfected with IFG – 1
Amount Awarded: 225,000
Funding Cycle: 3 Years
Project Status
Manuscripts and grant applications will be submitted when this research is completed.
2000 – Update not received.
2001 – Project Concluded
Pending Grants – NIH – This project plus larger projects. Plan to submit 10/01
Title of Grant
“Cost and Cost Effectiveness of Reconstruction vs. Amputation”
Principal Investigator
Ellen MacKenzie, PhD
Amount and Date funded
$27,263 January 1999
Presentations
None
Publications
Pending publications:
1) Long-term Costs of Amputation vs. Reconstruction
2) Indirect Costs of Major Lower Limb Trauma
Additional Grants and Awards
Grant/Award Title: Six-year Follow-up of LEAP Study Patients
Amount Awarded: $1,507,623
Funding Cycle: NIAMS/1999 - 2002
Project Status
2001 - Data collection and analysis completed; publications planned, manuscripts are drafted.
Title of Grant
“The Role of Angiogenesis in Bone Development and Repair”
Principal Investigator
Theodore Miclau, MD
Amount and Date funded
$20,000 January 1999
Presentations
Orthopaedic Research Society, 2000 & 2001; Orthopaedic Trauma Association,
2000 & 2001
Publications
Current Opinions in Orthopaedics, 2001
Journal of Orthopaedic Research, 2003
Development, 2003
Additional Grants and Awards
Grant Award/Title: Musculoskeletal Transplant Foundation
Amount Awarded: $225,000
Funding Cycle: January 2000 – January 2003
Grant Award/Title: National Institute of Health
Amount Awarded: $500,000
Funding Cycle: April 2000 – April 2006
Project Status
Completed
Title of Grant
“Pathogenesis and Prevention of Ankle Osteoarthritis after Tibial Plafond
Fractures”
Principal Investigator
J. Lawrence Marsh, MD
Amount and Date funded
$15,000 January 1999
Presentations
Orthopaedic Trauma Association Annual Mtg., October 2003;
27th Annual Meeting of the American Society of Biomechanics, September 2003;
Orthopaedic Research Society Annual Mtg., March 2004; Mid-America Orthopaedic Association Annual Mtg., April 2004; VA Medical Center Research Week (Iowa City), March 2004; American Academy of Orthopaedic Surgeons Annual Mtg., March 2004;
Orthopaedic Trauma Association Annual Mtg., October 2004; 4th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery, June 2004; American Academy of Orthopaedic Surgeons Annual Mtg., February 2005
Publications
Journal of Bone & Joint Surgeons, 2003 Feb.; 85-A(2): 287-95
Clinical Orthopaedic and Related Research, June 2004
Journal of American Academy of Orthopaedic Surgeons, May 2003
Additional Grants and Awards
Grant/Award Title: NIH/SCOR Grant
Amount Awarded: $750,000
Funding Cycle: Sept. 2002 – Sept. 2007
Grant/Award Title: Arthritis Foundation
Amount Awarded: $8,789
Funding Cycle: July 2003
Project Status
2003 - This project is not concluded, and work continues in the following areas:
Full development of website database.
Four sites continue to enroll study patients, submit data to central database and follow outcomes.
An additional study site has been added to the Plafond group.
Continue to review preliminary data and currently have 20 patients enrolled.
The laboratory continues to gather data…measurement of injury severity and quality of fracture reduction.
2005 – Expected publication submission after final data collection of 2-year data
(Dec. 2004 – Jan. 2005)
Title of Grant
“The Effect of Sacral Fracture Malreduction on the Safe Placement of Iliosacral
Screws: An Intraosseous Anatomic Study”
Principal Investigator
Mark Reilly, MD
Amount and Date funded
$12,000 January 1999
Presentations
Orthopaedic Trauma Association, October 1999; AAOS - OTA Specialty Day, 2000;
Orthopaedic Trauma Association, October 2000, American Academy of Orthopaedic
Surgeons, 2000
Publications
Journal of Orthopaedic Trauma, June 2001 (pending)
Additional Grants and Awards
Grant/Award Title: AONA
Amount Awarded: $10,000
Funding Cycle: 2001 - 2002
Project Status
2001 – Project concluded
Title of Grant
“An Investigation of Influence of Fat Embolism and Hypotension on Pulmonary
Pathophysiology”
Principal Investigator
Emil Schemitsch, MD
Amount and Date funded
$59,848 January 1999
Presentations
Orthopaedic Research Society, February 2002
International Society for Fracture Repair, September 2002
Canadian Orthopaedic Association, June 2002
3 abstracts submitted to ORS for 2003
Publications
Manuscript submission pending to Journal of Orthopaedic Trauma
3 Papers for JOR in preparation.
Additional Grants and Awards
Submission to Canadian Institutes of Health Research pending.
Project Status
2001 – This grant was funded for a 2-year period. Part 1 is complete (2 abstracts and 1
journal submission). Part 2 will be complete in 6 months, leading to more presentations
and publications.
Pending grants: Submission to Canadian Institutes of Health Research planned for March
2002 – Project Complete
Title of Grant
“Kinematic and Kinetic Behavior of the Ankle Following Supination-External
Rotation”
Principal Investigator
Neil Sharkey, PhD
Amount and Date funded
$19,995 January 1999
Presentations
6th Annual Meeting of Gait and Clinical Movement Analysis Society, Sacramento,
California, 2001
International Meeting of the Biomechanics Society, July 2001
Publications
Journal of Bone and Joint Surgeons, January 2002 (accepted in press)
Gait to Posture, March 2002 (accepted, minor revisions)
Additional Grants and Awards
The PI has been awarded funding (as Co-Principal Investigator) for research projects that will employ methods developed or perfected over the course of our OTA funded work, although they have a different research focus. We are also exploring the possibility of submitting an NIH grant aimed at total ankle arthroplasty, which is more closely related to our trauma research.
Bone Strain During OG Exercise (NASA), $718,639, 6/1/00-5/31/03
Therapeutic Footwear in Diabetes (NIH), $998,308, 7/1/00-6/30/03
2002 – New grant applications related to this research will be submitted this year.
Project Status
1999 – Project is ongoing. All experiments have been completed and data analysis in underway. Anticipate at least 2 presentations (ORS, OTA and/or ASB), and publication in JOT, FGA.
2000 – We are currently preparing two manuscripts that correlate with the two aforementioned abstracts, but contain a large amount of additional material. We anticipate these to complete by January 2001. The first will submitted to the Journal of Bone and Joint Surgery and the second to the Journal of Biomechanics.
2001 – Project will not be considered complete until at least two manuscripts have been accepted for publication.
2002 – Project Complete (Pending Grant: Biomechanical Factors Affecting Stress Reactions to Fractures; to be submitted in 2002 – 2003).
Title of Grant
“Effect of Articular Step-Off and Presence or Absence of the Meniscus on
Contact Pressures of Fractures of the Lateral Tibial Plateau”
Principal Investigator
Philip Wolinsky, MD
Amount and Date funded
$9,000 January 1999
Presentations
Poster – Orthopaedic Trauma Association, 1999
Publications
Journal of Orthopaedic Trauma, vol. 15(2):101-106, 2001
Additional Grants and Awards
Grant/Award Title: Zimmer
Amount Awarded: To be determined
Funding Cycle: 2001
Project Status
2000 - Ongoing
2001 – Project Complete
1998
OTA 1998 GRANT AWARDS
(Grant Cycle: January 1, 1998 – December 31, 1998) |
Title of Grant
“The Effect of Ultrasound on Distraction Osteogenesis”
Principal Investigator
Fred Behrens, MD
Amount and Date funded
$19,982 January 1998
Presentations
Orthopaedic Research Society, March 2000; ASAMI, March 2000
Publications
Manuscript in preparation
Additional Grants and Awards
Grant/Award Title: NSF/Effect of Mechanical Loading History on Distraction Osteogenesis Amount Awarded: $195,000 Funding Cycle: May 2000 – May 2004
Project Status
Project Concluded
Title of Grant
“Surfactants for the Disinfection of Complex Wounds”
Principal Investigator
Jeffrey Anglen, MD
Amount and Date funded
$20,000 January 1998
Presentations
OTA, 1998; Missouri State Orthopaedic Association, 1998; Musculoskeletal Infection Society 8th Annual Meeting, 1998; American Bone and Joint Surgeons; Association of Bone and Joint Surgeons, May 1999 and May 2000; Mid-America Orthopaedic Association, April 2000; Musculoskeletal Infection Society, August 2000; European Bone and Joint Infection Society, May 2000; Mid Central States Orthopaedic Society, June 2000
Publications
Journal of Orthopaedic Trauma, vol. 13 (5), 1999; American Journal of
Orthopaedics, vol. 28 (3), 1999; Southern Medical Journal, In press
Additional Grants and Awards
Grant/Award Title: VA Merit Award (same title)
Amount Awarded: $250,000
Funding Cycle: 3 years
Project Status
1999 - The project continues with additional funding as noted above, and more
publications are expected.
2000 – Project Concluded
Title of Grant
“Biomechanical Consequences of Femoral Head Impaction”
Principal Investigator
William Holmes, MD
Amount and Date funded
$10,000 January 1998
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
Project concluded.
Title of Grant
“An Economic Evaluation of Internal Fixation as Compared with Bipolar
Hemiarthroplasty for Displaced Femoral Neck Fractures”
Principal Investigator
Susan Jaglal, PhD
Amount and Date funded
$12,000 January 1998
Presentations
Hip Fracture Interest Group Symposium, University of Western Ontario, Keynote
Address, October 1998
Publications
Journal of Orthopaedic Trauma, vol. 12 (230-234), 1998
Journal of Bone and Joint Surgery, vol. 82-A (955-962), 2000
Additional Grants and Awards
None
Project Status
2002 – Completing data collection this year.
2003 – Project concluded. Manuscript in preparation
Title of Grant
“The Role of Apoptosis in Fracture Healing”
Principal Investigator
Kalia Sadasivan
Amount and Date funded
$29,800 January 1998
Presentations
None
Publications
Journal of Orthopaedic Trauma, vol. 13, 1999
Mol. Biol., vol. 46, 2000
J. Trauma, vol. 48, 2000
Additional Grants and Awards
The grant led to additional awards, but not to a larger grant. An orthopaedic
resident (MLO) received awards from the Orthopaedic Research and Education
Foundation and the Mid-America Orthopaedic Association. On the basis of that
work, she earned a fellowship in orthopaedic research at the Karolinska Institute.
Project Status
Project Concluded
Title of Grant
“The Effects of Locally Applied Antibiotics on Human Fibroblasts and T-
Lymphocytes in Vitro”
Principal Investigator
Theodore Miclau, MD
Amount and Date funded
$9,465 January 1998
Presentations
“Orthopaedic Trauma Association Annual Meeting, October 1999; Orthopaedic Research Society”, March 2000
Publications
Submitted to: Journal of Orthopaedic Research
Additional Grants and Awards
None
Project Status
2000 - The project is not yet fully concluded.
2001 – No changes.
2002 – No changes.
2003 – Project concluded
Title of Grant
“A Molecular Approach to Accelerate Fracture Repair”
Principal Investigator
Theodore Miclau, MD
Amount and Date funded
$20,000 January 1998
Presentations
Orthopaedic Trauma Association, Annual Meeting, October 1998; American Academy of Orthopaedic Surgeons, 66th Annual Meeting, February 1998; Orthopaedic Research Society, 45th Annual Meeting, February 1999; Orthopaedic Research Society, 1999; Orthopaedic Trauma Association, 1999; American Academy of Orthopaedic Surgeons, 1999; Orthopaedic Research Society, 2000
Publications
Annals of the New York Academy of Sciences, vol. 857, 1998
Does adult fracture repair recapitulate embryonic skeletal formation? Mechanisms
of Development, 1999
Journal of Orthopaedic Research, 2001
Additional Grants and Awards
Grant/Award Title: OREF - Howmedica Grant
Amount Awarded: $150,000
Grant/Award Title Musculoskeletal Transplant Foundation
Amount Awarded: $225,000
Funding Cycle: January 2000 – January 2003
Grant/Award Title National Institute of Health
Amount Awarded: $500,000
Funding Cycle: April 2000 – April 2005
Project Status
2000 – Manuscript in preparation
2002 – Project concluded.
1997
OTA 1997 GRANT AWARDS
(Grant Cycle: January 1, 1997 – December 31, 1997) |
Title of Grant
“Similarities in the Molecular Cues Mediating Bone Formation and Repair”
Principal Investigator
Anh Le, MD
Amount and Date funded
$11,500 January 1997
Presentations
Orthopaedic Research Society, 1997; Inman and Abbot Society Meeting, 1997;
Orthopaedic Trauma Association, 1997
Publications
Skeletal Growth and Morphogegesis; another work is in preparation.
Additional Grants and Awards
Grant/Award Title: Orthopaedic Research Educational Funds
Amount Awarded $15,000
Project Status
Project concluded.
Title of Grant
“A Prospective Field Trial to Assess the Reliability, Validity, and Responsiveness
of the Short Form Musculoskeletal Function Assessment Instrument (SMFA)”
Principal Investigator
Marc Swiontkowski, MD
Amount and Date funded
$43,682 January 1997
Presentations
American Academy of Orthopaedic Surgeons, 1997; Visiting Professorships; Maine
Medical Assessment Foundation, 1997; AAOS Symposium, 1998; Canadian Orthopedic
Association Annual Mtg, 1998; OTA, 1999; AAOS (x2), 2000
Publications
JBJS, September 1997, vol. 79A, pgs. 1323-1335
JBJS, September 1999, vol. 81A, pgs. 1245-1260
Pending Publications for Orthopaedics and Journal of Medical Outcomes
Pending Publications: “Use of Interactive Voice Response as a mode of Admission” SMFA - Date submitted: February 2000
“Feasibility of using SMFA in Office Practice” JBJS, Date Submitted: August 1999
Additional Grants and Awards
None
Project Status
1999 - Project in data analysis phase. Anticipate publication in approx. 1 year.
2000 – Project Concluded.
Title of Grant
“Therapeutic Role of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in
Infected Fractures of Rabbit”
Principal Investigator
Andrew Schmidt, MD
Amount and Date funded
$19,892 January, 1997
Presentations
None
Publications
None
Additional Grants and Awards
Grant/Award Title: OTA Grant, “BME Treatment of the Infected Bone Defect”
Amount Awarded: $18,263
Funding Cycle
2000-2001
Project Status
1999 – Possible publications and related grants expected.
2000 – Project Concluded (Pending Grant from NIH)
2001 – Project Concluded
Title of Grant
“Mechanical Strength of Fracture Callus in Osteopenic Bone at Different Phases of
Healing”
Principal Investigator
Donna Wheeler, PhD
Amount and Date funded
$24,914 January 1997
Presentations
Orthopaedic Trauma Association, October 1998
Publications
Journal of Orthopaedic Trauma, vol. 14(2):86-92, 2000
Additional Grants and Awards
None
Project Status
Additional publications and related grants expected.
2000 – Update not received.
2001 – Project Concluded
Title of Grant
“Mechanical Influences on Fracture Repair Process”
Principal Investigator
James Goulet, MD
Amount and Date funded
$21,500 January 1997
Presentations
Orthopaedic Research Society, 1997 and 1998
American Society of Mechanical Engineers, 1997
Publications
Journal of Bone and Mineral Research, November 1997; Journal of Clinical I
Investigation, October 1997; Journal of Bone Mineral Research, vol. 14(11), November
1999; Journal of Bone Mineral Research, vol. 15(5), May 2000
Additional Grants and Awards
Grant/Award Title: NIH
Musculoskeletal Core Center: Mechanical and Biological Influences on Bone Response
Amount Awarded: $3,006,395
Funding Cycle: 4/1/01 – 3/30/06
Project Status
Project status unknown. Update not received in 1999.
2000 – Update not received.
2001 – Project concluded.
Title of Grant
“Development of an In-Vivo Model of Long-Term Consequences of Acetabular Fractures”
Principal Investigator
Steven Olson, MD
Amount and Date funded
$19,717 January 1997
Presentations
Orthopaedic Trauma Association, October 1998
Orthopaedic Research Society – pending 2002
Publications
Pending Publications: Development of an in-vivo model of Intra-articular fx.
Additional Grants and Awards
Pending
Project Status
2001 – Project Concluded
Pending Grants: ORS Career Development Award – Submitted 8/2001
NIH RO3 – Submitted 2/2001
Genetics Institute – Submitted 6/2001
Title of Grant
“Role of Endogenous Hormones in the Control of Bone Blood Flow”
Principal Investigator
John Fleming, PhD
Amount and Date funded
$15,000 January 1997
Presentations
Gill Heart Institute Research Forum, October 1998; Orthopaedic Research Society Annual Meeting, 1999; Seminar Presentation, Rudd Heart & Lung Institute, August 1999; Seminar Presentation, Indiana State University, October 1999; Thesis defense, University of Louisville, July 1999; Accepted for Presentation at the AAOS 67th Annual Meeting, 2000; Submitted to Orthopaedic Research Society Annual Meeting, 2000;
Publications
Submitted to Microcirculation, October 1999
Journal of Orthopaedic Research 20:391-396, 2002
Additional Grants and Awards
Grant/Award Title: National Institutes of Health, Aging Institute
“Estrogen: Bone blood flow and Bone Biomechanical Properties”
Amount Awarded: $50,000
Funding Cycle: 6/1/99 – 5/30/01
Grant/Award Title: Fischer-Owen Orthopaedic Research Fund
“Effect of Low Level Ultrasound Stimulation on Bone Blood Flow”
Amount Awarded: $14,924
Funding Cycle: 1/1/99 – 12/31/99
Grant/Award Title: University of Louisville, School of Medicine
“Cortical Bone Vascular Reactivity Following Bone Injury”
Amount Awarded: $15,000
Funding Cycle: 1/1/99 – 12/31/99
Project Status
1999 – Jeremy Feitelson, a graduate student in my lab, conducted his Master’s thesis research in one area of this grant. He has now enrolled in the doctoral program and plans to conduct his dissertation research in a bone blood flow area. He has not decided if his PhD research will continue in the same area or a new area of bone blood flow regulation. Additional papers and presentations related to the topic of the grant will be forth coming if he decides to continue in the thesis research area for his dissertation research. However, since the OTA funding expired some time ago, funding for this future research must come from other sources.
2002 – Project concluded.
Title of Grant
“Periarticular Bone Strain Changes Resulting from Pilon Fractures: The Effect of
Cartilage and Subchondral Bone Loss”
Principal Investigator
Todd McKinley, MD
Amount and Date funded
$15,000 January 1997
Presentations
Biomed Engineering Society, October 1998; AOA Resident’s Conference,
March 1999; Orthopaedic Trauma Association, October 1999; Orthopaedic Research
Society (multiple), February 1999
Publications
Journal of Orthopaedic Research, September 2001, 19(5): 906-13
Journal of Orthopaedic Trauma, 2001; CORR, 2001; Journal of Biomechanical Engineering, 2001; Journal of Orthopaedic Trauma, 2002 October, 16(9): 638-43;
Journal of Orthopaedic Trauma, 2002 November – December, 16(10): 709-16;
Journal of Biomechanical Engineering, 2003 February, 36(2): 155-63;
Clin Orthop., 2003 February, (407): 259-67
2 articles accepted for: Journal of Orthopaedic Trauma Accepted 2002
Additional Grants and Awards
Grant/Award Title: Bank of America Gianinni Foundation Medical Research
Amount Awarded: $25,000
Funding Cycle: Over
Grant/Award Title: OREF/Zimmer Career Development
Amount Awarded: $50,000
Funding Cycle: 2001 – 2002
Grant/Award Title: National Institute of Health/Pathomechanical Etiology of Post-
Traumatic Arthritis
Amount Awarded: $320,000
Funding Cycle: 2003
Grant/Award Title: “Centers for Disease Control: Traumatic Injury Biomechanics Research/
Unstable Joints: Cartilage Stress Anomaly and Osteoarthritis”
Amount Awarded: $890,000
Funding Cycle: 2003
Project Status
2000 – Pending Publications: Journal of Orthopaedic Research, Date Submitted:
August 2000; CORR, Date Submitted: August 2000
Pending Grants: OREF/Zimmer, Date Submitted: October 2000
2001 – Project not concluded, finishing manuscripts
Pending Grants: SCOR Grant, Univ. of Iowa – submitted 9/01
2002 – Pending Grant: Centers for Disease Control, Biomechanics of Injury Grant
2003 – Project Concluded
1996
OTA 1996 GRANT AWARDS
(Grant Cycle: January 1, 1996 – December 31, 1996) |
Title of Grant
“Development of an In Vivo Die-punch Intra-articular Fracture Model”
Principal Investigator
Joseph Borrelli, MD
Amount and Date funded
$12,000 January 1996
Presentations
Orthopaedic Trauma Association, 1995; Local research meeting at the Hospital
for Special Surgery, New York; (Note: Dr. Borelli believes this work was
presented at a national biomechanical meeting by Dr. P. Torzilli (co-investigator).
He will contact Dr. Torzilli at Hospital for Special Surgery to confirm.)
Publications
Journal of Orthopaedic Trauma, 1997; Journal of Biomechanical Engineering, Vol. 121(5); Pgs 433-441, 1999
Additional Grants and Awards
Grant/Award Title: OREF (foundation grant #98-009)
Amount Awarded: $50,000/year
Funding Cycle 2 years
Grant/Award Title: “OREF, Articular Cartilage Damage Following Impact Load: An in-vivo Rabbit Model”
Amount Awarded $100,000
Funding Cycle: July 1998 – June 2000
Project Status
1999 – The apparatus constructed from these funds will continue to be utilized to assess the effects of the rate of load application on articular cartilage. It is anticipated that the results of these experiments will be published in the future.
2000 – Project Concluded
Title of Grant
“In Vitro Stability and Contact Stresses of the Hip Following Simulated Acetabular Fractures”
Principal Investigator
Kevin Thomas, PhD
Amount and Date funded
$16,500 January 1996
Presentations
American Society of Biomechanics, September 1997; Poster Exhibit, Southern Biomedical Engineering Conference, April 1997; Orthopaedic Trauma Association, October 1997; American Academy of Orthopaedic Surgeons, March 1998; Orthopaedic Research Society, March 1998
Publications
Proceedings of the 16th Annual Southern Biomedical Conference, 1997; Journal of Rehabilitation Research and Development, vol. 34, 1997; Conference Proceedings of the 21st Annual Meeting of the American Society of Biomechanics, 1997; Journal of Rehabilitation Research and Development, vol. 35, 1998; Orthopaedic Transactions, vol. 21(4), 1997 – 1998; Transactions of the Orthopaedic Research Society, vol. 22, 1998; Orthopaedic Transactions, vol. 22(1) 1998 – 1999; Journal of Bone and Joint Surgery, vol. 81A, 1999
Additional Grants and Awards
Grant applications submitted to AO ASIF Research Commission, Louisiana Board
of Regents Support Fund, and Orthopaedic Research and Education Foundation.
None received funding.
Project Status
2001 – Project concluded.
Title of Grant
“Assessment of Reamer System Mechanical Loads and Resultant Histopathology as
Factors Affecting Intramedullary Pressurization”
Principal Investigator
Richard Peindl, PhD
Amount and Date funded
$14,595 January 1996
Presentations
43rd Meeting of the Orthopaedic Research Society, February 1997; ASME/AIChE/ASCE Bioengineering Conference, June 1997; American Orthopaedic Association Residents' Conference, March 1997
Publications
Journal of Orthopaedic Trauma, vol. 12, 1998
Proceedings of the 1997 Bioengineering Conference, ASME, June 1997
Proceedings of Orthopaedic Transactions, vol. 21, 1997- 1998
Additional Grants and Awards
Grant/Award Title: "The Development of a Biological Safe Intramedullary Reamer
System"
Genetics Institute
Amount Awarded: $5,000
Project Status
1999 – Project led to development of an alternative reamer head design; currently
investigating commercialization with orthopaedic companies.
2000 – Project concluded.
Title of Grant
“The Effects of Applied Intermittent Vibration On Fracture Healing in the Rabbit Tibial
Osteotomy Model”
Principal Investigator
James Nepola, MD
Amount and Date funded
$18,628 January 1996
Presentations
Orthopaedic Trauma Association, 1996
Publications
None
Additional Grants and Awards
Grant Submitted to EBI
Project Status
Project concluded.
Title of Grant
“The Effectiveness of Unipolar Versus Bipolar Prostheses in the Clinical Management of the Elderly with Displaced Fracture of the Femoral Neck: A Pilot Study”
Principal Investigator
Harry Rubash, MD
Amount and Date funded
$16,000 January 1996
Presentations
MGH Service Line Development Committee
Publications
None
Additional Grants and Awards
None
Project Status
1999 – Dr. Rubash moved to MGH from UPMC in 1998. The OREF grant was
transferred, and we are in the process of getting the study approved at MGH.
2000 – The pilot is concluded. We are considering a multi-center trial.
Pending Grant: Re-submit NIH Grant as multi-center study based in Boston hospitals.
2001 – Project concluded. Considering re-submitting to NIH as multi-center study at
Partners Hospital.
Title of Grant
“The Effect of Nicotine on Tibial Shaft Fracture Healing in the Rabbit Model”
Principal Investigator
Maureen Finnegan, MD
Amount and Date funded
$20,000 January 1996
Presentations
Orthopaedic Trauma Association Annual Meeting, 1997; AAOS Specialty Day, 1998; Canadian Orthopedic Association, 1999; Association of Bone and Joint Surgeons, 1999
Publications - None
Additional Grants and Awards
None
Project Status
1999 – Presently working on publication
2000 – Project Concluded
Title of Grant
“Does Bone Morphogenetic Protein Accelerate Fracture Healing in a Rabbit Limb Lengthening Model?”
Principal Investigator
Fred Behrens, MD
Amount and Date funded
$17,740 January 1996
Presentations
Research Round, UMDNJ; Orthopaedic Trauma Association, 1998
Society for Biomaterials, April 1999
New Jersey Biomaterials Center Symposium, June 2000
Publications
Trans. Soc. Biomater, vol. 21, 1998; Trans. Soc. Biomater, vol. 22, 1999;
Transactions Orthopaedic Trauma Association, 1998; Soc. Biomater, 1998
Additional Grants and Awards
Grant/Award Title: Student Fellowship for the Whitaker Special Opportunity Award for
Statewide Program in Biomaterials Science
Amount Awarded: $23,010
Grant/Award Title: Materials donated by Intermedics Orthopaedic
Amount Awarded: $5,400
Grant/Award Title: Materials donated by Sulzer Orthopedics Biologics, Inc.
Amount Awarded: $10,320
Project Status
Pending Publication: PhD Dissertation (Lisa Holt) Date Submitted: January 2001
Pending Publication: Journal Article (2) to be submitted, January 2001
2001 – Publications undergoing revisions.
2002 – Project Concluded
Title of Grant
“Acute Lung Injury Associated with Femoral Shaft Fractures”
Principal Investigator
Andrew Pollak, MD
Amount and Date funded
$18,900 January 1996
Presentations
Orthopaedic Trauma Association Meeting, 1998
Publications
JOT, November 2000 (pending publication)
Additional Grants and Awards - None
Project Status
1999 – More publications expected
Title of Grant
“The In-Vivo Effect of Locally Applied Aminoglycosides on Bone Healing”
Principal Investigator
Theodore Miclau, MD
Amount and Date funded
$14,700 January 1996
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
2002 – Project concluded.
1995
OTA 1995 GRANT AWARDS
(Grant Cycle: January 1, 1995 – December 31, 1995) |
Title of Grant
“The Efficacy of Gentamicin Impregnated Resorbable Calcium Phosphate
Cement in Treating Experimental Osteomyelitis in a Rat Model”
Principal Investigator
Michael Baumgaertner, MD
Amount and Date funded
$12,000 January 1995
Presentations
Orthopaedic Trauma Association, 1997
Publications
Journal of Orthopaedic Trauma, Vol. 13, No. 2, 1999
Additional Grants and Awards
No
Project Status
2001 – Project Concluded
Title of Grant
“Percutaneous Screw Insertion to Sacroliac Complex: Bony Anatomy”
Principal Investigator
Fred Behrens, MD
Amount and Date funded
$10,000 January 1995
Presentations
Poster Presentations at Orthopaedic Research Society and AOA Meetings; SICOT, 1999; OTA, 1996 and 1997
Publications
Manuscript is undergoing further revisions and to be resubmitted by 7/1/03.
Additional Grants and Awards
Grant/Award Title: Related OTA grant to Dr. Mark Reilly
Amount Awarded: $17,000
Funding Cycle: 1998/1999
Project Status
2000 - Project Complete (Publication to be submitted November 2000)
2001 – Publication undergoing revisions 11/00
2002 – Manuscript to be re-submitted
2003 – Project Concluded
Title of Grant
“Reamed Intramedullary Nailing in the Face of Pulmonary Injury in Sheep”
Principal Investigator
Kenneth Johnson, MD
Amount and Date funded
$12,000 January 1995
Presentations
Canadian Orthopaedic Association Annual Meeting, 1997; AAOS
Publications
Journal of Orthopaedic Trauma, vol. 12(3), 1998
Additional Grants and Awards
None
Project Status
Project concluded.
Title of Grant
“Randomized Multicenter Clinical Trial of Distal Radius Fracture Treatment”
Principal Investigator
Hans Kreder, MD
Amount and Date funded
$10,000 January 1995
Presentations
American Academy of Orthopaedic Surgeons, 1995; Manus, 1995; Canadian Orthopaedic Association, 1995; SICOT, 1999; Orthopaedic Trauma Association, 1999;
COA, 1999 and 2000
Publications
Journal of Hand Surgery, vol. 21A(1), 1996
Journal of Bone and Joint Surgery, vol. 78-B, 1996
Additional Grants and Awards
Grant/Award Title: OREF
Amount Awarded: $144,760
Grant/Award Title: University of Toronto
Amount Awarded: $44,915
Project Status
1999 - Enrollment into one study arm is completed. The other study arm is ongoing.
Three additional publications are expected, one of which will be
submitted within the next few months.
2001 – Last patient enrolled in arm 2 in 1999, follow-up ended in April 2001.
Last patient enrolled in arm 1 in 2000, follow-up will end in October 2001
Interim data not submitted as planned. Plan is to submit two final papers only.
2003 – Publications pending.
Title of Grant
“Displaced Acetabular Fractures: Influence of Surface Displacement on Articular Cartilage and Subchondral Bone Stress Distribution”
Principal Investigator
Michael Voor, MD
Amount and Date funded
$10,000 January 1995
Presentations
American Academy of Orthopaedic Surgeons; Mid-America Orthopaedic Association; Orthopaedic Trauma Association, 1997
Publications
Not Yet
Additional Grants and Awards
None
Project Status
1999 - Project concluded, but a manuscript is under internal review for
submission to the Journal of Orthopaedic Trauma.
2000 - A manuscript remains in preparation. OTA will be informed when it goes
out for review.
2001 – No changes to report.
2002 – No changes to report.
2003 – No changes to report.
1994
OTA 1994 GRANT AWARDS
(Grant Cycle: January 1, 1994 – December 31, 1994) |
Title of Grant
“Notch Sensitivity of Intramedullary Rods”
Principal Investigator
Richard Kyle, MD
Amount and Date funded
$10,000 January 1994
Presentations
Orthopaedic Trauma Association; American Academy of Orthopaedic Surgeons
Publications
Preparing for publication
Additional Grants and Awards
None
Project Status
Project concluded.
Title of Grant
“The Effect of Intramedullary Nail Design and Insertion Method on Blood Flow in a
Tibia Fracture Model”
Principal Investigator
Emil Schemitsch, MD
Amount and Date funded
$9,690 February 1994
Presentations
Orthopaedic Trauma Association, October 1997; Canadian Orthopaedic Research Society, June 1997; Canadian Orthopaedic Association, June 1998; International Society for Fracture Repair, September 1998; American Academy of Orthopaedic Surgeon, March 1998; Orthopaedic Trauma Association, October 1998
Publications
Journal of Orthopaedic Trauma, vol. 12 (6), 1998
2nd publication submitted to Journal of Orthopaedic Trauma
Additional Grants and Awards
Grant/Award Title: “Assessment of single fiber implantable laser Doppler
Flowmetry in a canine segmental tibial fracture model.”
Physicians Service Incorporated Foundation
Amount Awarded: $46,540
Funding Cycle: 1996 - 1997
Project Status
Project Concluded
Title of Grant
“Unilateral Facet Fracture in C-Spine”
Principal Investigator
Stephen Belkoff, MD
Amount and Date funded
$10,000 February, 1994
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
2000 – Injury creation phase is complete. Repair phase is better than half complete
2001 - (15/18 specimens). The remaining 3 spines have been harvested and await
Testing in August.
2004 – Project completed
Title of Grant
“Pulmonary Sequelae After Reamed Intramedullary Femoral Nailing in Patients with
Multiple Trauma - Differences According to Reamer Systems”
Principal Investigator
Hans-Christoph Pape, MD
Amount and Date funded
$10,000 February 1994
Presentations
South German Congress of Surgery, 1995; International Symposium of the Science of IM
Reaming, 1995, Hong Kong; International Congress on Intensive Care
Medicine, 1997, Bremen, Germany; OTA/AAST October 2000 “Major secondary surgery
in blunt trauma patients and preoperative cytokrim liberation” Pape et al;
Publications
Critical Care Medicine, (in press) Vol. 28, no. 10 “Biochemical changes after
Trauma and Skeletal surgery of the lower extremity: Qualification of the operative
burden” Paper et al.; Journal of Trauma submission August 2000.
Additional Grants and Awards
Grant Award/Title: AO/ASIT MP-65
Amount Awarded: $108,000
Funding Cycle: 2 years
Project Status
Project Completed
Title of Grant
“The Osteogenic Response to Bleeding and Intramedullary Trauma”
Principal Investigator
Thomas Einhorn, MD
Amount and Date funded
$19,604 May 1994
Presentations
American Orthopaedic Association, 1993
Orthopaedic Research Society, 1996
Publications
Clinical Orthopaedics and Related Research, 1997
Additional Grants and Awards
None
Project Status: Project Complete
Title of Grant
“Consequences of Acetabular Fractures on Load Transmission Across the Hip Joint”
Principal Investigator
Steven Olson, MD
Amount and Date funded
$20,000 February 1994 and January 1995
Presentations
American Academy of Orthopaedic Surgeons, 1993 and 1995; Orthopaedic Trauma Association, September 1996, October 1997 and October 1998; International Consensus on Surgery of the Pelvis and Acetabulum, 1994, 1996, and 1998; Western Orthopaedic Association, August 1996; International Symposium for Results of Surgically Treated Acetabular Fractures, Paris, France, 1993.
Publications
Journal of Bone and Joint Surgery, vol. 8, 1995; Journal of Orthopaedic Trauma,
vol. 10, 1996; Journal of Biomechanics, vol. 30, February 1997; Clinical Orthopaedics
and Related Research, June 1997; Journal of Orthopaedic Trauma, vol. 12, 1998;
Journal of Orthopaedic Trauma, March/April 1998; Journal of Bone and Joint Surgery,
vol. 80A(12), 1998; Journal of Orthopaedic Trauma, vol. 13 (6), 1999
Additional Grants and Awards
Grant/Award Title: AO/ASIF
Amount Awarded: $16,000
Funding Cycle: 1996-1997
Grant/Award Title: OTA
Amount Awarded: $10,000
Funding Cycle: 1997
Project Status
2001 – Project Concluded
1993
OTA 1993 GRANT AWARDS
(Grant Cycle: January 1, 1993 – December 31, 1993) |
Title of Grant
“Internal Fixation of Experimental Calcaneus Fractures: A Biomechanical Analysis of
Two Fixation Methods”
Principal Investigator
James Carr, MD
Amount and Date funded
$14,000 January, 1993
Presentations
Virginia Orthopedic Society, 1994; MCV Resident's Day 1995
Virginia Orthopedic Society, 1996; Minimal Invasive Traumatology, Austria,
1996
Publications
Journal of Orthopaedic Trauma, vol. 11, 1997
Additional Grants and Awards
None
Project Status
Project Concluded
Title of Grant
“The Strength of Plate Fixation in Relation to the Number, Spacing and Holding
Power of Bone Screws”
Principal Investigator
Trevor Hearn, PhD
Amount and Date funded
$10,000 January 1993
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
Project concluded.
Title of Grant
“Bone Toxicity of Locally Applied Antibiotics”
Principal Investigator
Theodore Miclau, MD
Amount and Date funded
$10,000 January 1993
Presentations
Orthopaedic Research Society, 40th Annual Meeting, February 1994; American Orthopaedic Association, 27th Annual Resident's Meeting, March 1994; American Orthopaedic Association, 107th Annual Meeting, June 1994; Orthopaedic Trauma Association, Annual Meeting, September 1994; American Academy of Orthopaedic Surgeons, 62nd Annual Meeting, February 1995; Orthopaedic Research Society, 41st Annual Meeting, February 1996; American Academy of Orthopaedic Surgeons, 63rd Annual Meeting, February 1996
Publications
Journal of Orthopaedic Trauma, vol. 9, 1995
Clinical Orthopaedics and Related Research, vol. 333, 1996
Additional Grants and Awards
OTA, January 1998 $9,465
"The Effects of locally applied antibiotics on human fibroblasts and t-lymphocytes
in-vitro"
Project Status
1999 - An additional project manuscript is in preparation entitled "Gentamicin
Wound Irrigation."
2002 – Project Concluded
Title of Grant
“Development of Quantitative Predictors of Fixation in Femoral Neck Fractures”
Principal Investigator
Allan Tencer, PhD
Amount and Date funded
$14,000 January 1993
Presentations
Orthopaedic Trauma Association; Orthopaedic Research Society
Publications
Journal of Orthopaedic Research, vol. 14, 1996
Journal of Orthopaedic Trauma, vol. 10, 1996
Journal of Orthopaedic Trauma, vol. 11, 1997
Injury 32:223-228, 2001
Additional Grants and Awards
Grant/Award Title: OREF
Amount Awarded: $98,000
Grant/Award Title: Norian Corp.
Amount Awarded: $50,000
Project Status
Project concluded
1992
OTA 1992 GRANT AWARDS
(Grant Cycle: January 1, 1992 – December 31, 1992) |
Title of Grant
“Periosteal Injury”
Principal Investigator
James Nepola, MD
Amount and Date funded
$13,000 1992
Presentations
Iowa Alumni Meeting, 1996
Publications
None
Additional Grants and Awards
None
Project Status
Project concluded.
Title of Grant
“Galium Nitrate”
Principal Investigator
Charles Cornell, MD
Amount and Date funded
$11,500 1992
Presentations
None
Publications
None
Additional Grants and Awards
None
Project Status
Project Concluded
Title of Grant
“A Multi-Centre Randomized Controlled Clinical Trial Comparing Operative and
Non-operative Treatment of Displaced Intra-Articular Fractures of the Calcaneus”
Principal Investigator
Richard Buckley, MD
Amount and Date funded
$10,000 January, 1992 renewed $10,000 January, 1993
Presentations
CAA, 1994; CAA, 1995; International Society of Biomechanics; Orthopaedic Trauma Association, 1996; Canadian Orthopaedic Association Meeting, May 1996; Orthopaedic Trauma Association Meeting, September 1996; Canadian Orthopaedic Association Meeting, June 1997; Orthopaedic Trauma Association Meeting, October 1997; American Academy of Orthopaedic Surgeons, February 1997; World Combined Meeting, New Zealand, February 1998; Orthopaedic Trauma Association Meeting, October 1998; American Academy of Orthopaedic Surgeons, March 1998; Canadian Orthopaedic Association Meeting, June 1998; Canadian Orthopaedic Association Meeting, July 1999; Orthopaedic Trauma Association, October 2000; American Academy of Orthopaedic Surgeons, February 2001; American Orthopaedic Foot and Ankle Society, 2001
Publications
Journal of Bone and Joint Surgeons, vol. 78B, January 1996; Foot and Ankle
International, vol. 18, no. 4, April 1997; Foot and Ankle International, vol. 19,
no. 10, October 1998; Journal of Orthopaedic Trauma, vol. 13, no. 8, 1999; Journal of
Orthopaedic Trauma, vol. 15, no. 4, 2001
“The Female Calcaneal Fracture," Journal of Orthopaedic Trauma
“CT Correlations of Displaced Intra-Articular Calcaneal Fractures,” JOT
“Complications of Management of Calcaneal Fractures,” Journal of Orthopaedic Trauma
“Subtalar Motion Correlations with Long Term Outcome” Foot & Ankle International
Additional Grants and Awards
Grant/Award Title: Pharmacia Grant/DVT Study
Amount Awarded: $250,000
Funding Cycle: 2000-2002
Edwin G. Bovill, Jr., MD OTA Specialty Day Award Winning Paper - 2000 OTA
Annual Meeting
Project Status
Project Status and Long-Term Impact of Research Award: This particular study has won significant awards wherever it has gone. It has been presented to the Canadian Orthopaedic Association, Foot & Ankle portion of the American Academy, Orthopaedic Trauma Association and to the American Academy Specialty Day. It won the Samson Award ($15,000) for best research submitted to the Canadian Orthopaedic Association Meeting. It won the Bovill Award as the best research for the year 2000 at the OTA. It has continued to enlighten people about calcaneal fractures and will be the definitive paper on displaced intra-articular fracture management when it is published. Initial funding was instrumental in its reaching these heights.
2001 – Project Concluded
……………………………………………………………………………………………………………………
1991
OTA 1991 GRANT AWARDS
(Grant Cycle: January 1, 1991 – December 31, 1991) |
Title of Grant
“Stability Evaluation and Comparison of Posterior, Anterior and Transpedicular Screw
and Spinal Implants”
Principal Investigator
Jeffery Stambough, MD
Amount and Date funded
$10,000 and 8,000 1991 and 1992
Presentations
University of Cincinnati
Publications
Journal of Special Disorders, 1998
Additional Grants and Awards
Yes, $25,000 in 1998
Project Status
Project Concluded
1990
OTA 1990 GRANT AWARDS
(Grant Cycle: January 1, 1990 – December 31, 1990) |
Title of Grant
“Effect of Isolated Talo Calcaneal Fusion on Contracting the Ankle and Talonavicular
Joint”
Principal Investigator
Robert Adelaar, MD
Amount and Date funded
$7,500 1990
Presentations
American Orthopaedic Foot and Ankle Society; Orthopaedic Club; Southern
Orthopaedic Association; Virginia Orthopaedic Association; Orthopedic Research
Society; Pediatric Orthopedic Society; Piedmont Orthopedic Meeting
Publications
Foot and Ankle Journal, vol. 12, 1991
Additional Grants and Awards
None
Project Status
Project Concluded
Title of Grant
"Mortality of Poly-trauma Patients with Early Fracture Management"
Principal Investigator
Lawrence Bone, MD
Amount and Date funded
$2,000 1990 & 1991
Presentations
Orthopaedic Trauma Association, 1993; AAST Annual Meeting 1993
Publications
Journal of Trauma, vol. 8, 1994
Additional Grants and Awards
None
Project Status
Project Concluded
………………………………………………………………………………………………………………………
Title of Study
"Immediate Versus Delayed Closure of Grade II and IIIA Tibia Fractures"
Grant Funded by
OTA
Chair William DeLong, MD
Amount and Date funded
$205,781 Funding Cycle: May 2000 – May 2002
The orthopaedic axiom that all open fractures should remain open until redebrided and closed in a delayed fashion dates back to Trueta. It has never been tested in modern times by a randomized prospective trial. It is currently the practice of many surgeons to primarily close open fractures, if closeable, after aggressive debridement and irrigation. The argument supporting this practice is that the wound will never be cleaner than it is at that period of time, and with a closed wound, the wound is protected from possible contamination by resistant organisms from the hospital. Literature on this topic is based on anecdotal experiences, personal exclamations, and “no true science” and does not currently support this approach in adult patients. This project has been designed to determine if there is a clinical and economic advantage to the patient with immediate fracture closure. Thirty North American trauma centers are participating in the study and beginning August 2001 data-entry from the twenty-three sites has been web-based.
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